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Background – digitalization in eastern European medical education is a stringent need of teaching and assessment processes, which must be updated to challenges continuously launched by medical students. In this context, our university implemented an e-learning and e-assessment system in histology, a preclinical education subject. Aim – to evaluate the impact of replacing a classic learning and assessment methods with a completely digitized one. Methodology – the new system impact on students’ skills and teacher’s performance, was evaluated by using an opinion pool questionnaire including as assessment criteria system compliance, student-teacher interaction, online access improvement and new facilities regarding e-assessment and time management was performed. Results – “computer gaming” was delightful for students. Management of information’s given to students was improved by a higher standardization and this, helped them to pass evaluations easier. Better stress management of examination induced the increase of attendance to first presentation. Graduation percentage and students’ confidence in the accuracy of the exam results were improved. Time for evaluation was significantly reduced giving to teachers the opportunity for a better management of their time dedicated to research or academic development. Teaching and exam module software was periodically updated, being adapted to our curriculum. Conclusions – e-learning and e-assessment had a quick positive impact on students and teacher’s despite of controversial issues which commonly come with any change