Descriptor: "Adenoviruses, Human drug effects" / Language: german - Searchworks@Jio Institute Digital Library Search Results

Subjects: Adenoviruses, Human drug effects, Chronic Disease, Humans, Influenza A virus drug effects, Respiratory Syncytial Virus, Human drug effects, Rhinovirus drug effects, Antiviral Agents therapeutic use, Flavonoids therapeutic use, Phytotherapy, Plant Extracts therapeutic use, Rhinitis drug therapy, Sinusitis drug therapy
Published: 2012

Author: Tonew M, Tonew E, Gutsche W, Wohlrabe K, Stelzner A, Schröer HP, and Heyn B
Subjects: Adenoviruses, Human drug effects, Animals, Cells, Cultured, Chick Embryo, Cisplatin therapeutic use, Dimethyl Sulfoxide administration & dosage, Drug Interactions, Drug Tolerance, Female, L Cells drug effects, Leukemia, Experimental drug therapy, Male, Mice, Mice, Inbred Strains, Solutions, Vaccinia virus drug effects, Vesicular stomatitis Indiana virus drug effects, Cisplatin pharmacology, Dimethyl Sulfoxide pharmacology
Abstract: In water or dimethyl sulfoxide solutions cis-platinum is subject of time depending solvolytic reactions leading to compounds with different biological effectivity. Whereas the inactivation of vaccinia, vesicular stomatitis and adeno virus type 5 was not changed if dimethyl sulfoxide or dimethyl formamide instead of destilled water were used as solvents, long time stored solutions of cis-platinum in dimethyl sulfoxide were tolerated by cells cultivated in vitro in 8-25 times higher concentrations in comparison with a freshly solved preparation. Their antiviral effectivity was maintained. On the other hand experiments with mice showed that simultaneously with the decrease of toxicity of an aged cis-platinum solution in DMSO also its antileukemic activity disappeared. In a 5 weeks old cis-platinum solution in destilled water antitumor activity was preserved in spite of enhanced toxicity.
Published: 1984

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