1. [Amyloidoses in neuropathology].
- Author
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Prokop S, Stenzel W, Goebel HH, and Heppner FL
- Subjects
- Aged, Alzheimer Disease genetics, Alzheimer Disease pathology, Amyloid analysis, Amyloid genetics, Amyloid beta-Peptides genetics, Amyloidosis genetics, Amyloidosis, Familial genetics, Amyloidosis, Familial pathology, Brain pathology, Cerebral Amyloid Angiopathy genetics, Cerebral Amyloid Angiopathy pathology, Cerebral Hemorrhage genetics, Cerebral Hemorrhage pathology, Diagnosis, Differential, Humans, Middle Aged, Neurodegenerative Diseases genetics, Neuromuscular Diseases genetics, Neuromuscular Diseases pathology, Peripheral Nerves pathology, Prion Diseases genetics, Prion Diseases pathology, Prognosis, Amyloid beta-Peptides analysis, Amyloidosis pathology, Neurodegenerative Diseases pathology
- Abstract
Amyloidoses play an important role in neuropathology, both in autopsies and biopsy specimens. Cerebral amyloidoses are typically characterized by the deposition of beta-amyloid and mostly affect patients >60 years. The cardinal symptom of cerebral amyloid angiopathy (CAA) is spontaneous intracerebral hemorrhage, whereas the clinical presentation of Alzheimer's disease is dementia. Rare familial forms of amyloidoses may affect young patients and need thorough neuropathological assessment, similar to the relatively infrequent prion diseases. Amyloidoses within neuromuscular tissues mainly occur in the setting of systemic amyloid diseases. Detailed evaluation including thorough characterisation of amyloid is essential for ensuring the neuropathological diagnosis.
- Published
- 2009
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