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5. [Effect of alcohol on the development of biochemical and morphologic findings of liver damage in the rabbit].

Author

Boroń P, Bobrowska E, Boroń-Kaczmarska A, Borzuchowska A, Bernaczyk A, Nowak HF, Kurasz S, Prokopowicz D, Szpakowicz T, and Sawicki Z

Subjects
Alanine Transaminase blood, Alkaline Phosphatase blood, Animals, Aspartate Aminotransferases blood, Cholesterol blood, Cholesterol Esters blood, Fatty Acids, Nonesterified blood, Fatty Liver, Alcoholic pathology, Fibrinogen metabolism, Guanine Deaminase blood, Hepatitis, Alcoholic pathology, Liver pathology, Liver Diseases, Alcoholic enzymology, Male, Rabbits, Triglycerides blood, Ethanol pharmacology, Liver Diseases, Alcoholic pathology
Abstract

Ethanol 48% was applied to the experimental model in 3 examined groups of rabbits in different periods of administration and differentiated daily doses on order to investigate the influence of ethanol upon the formation of morphological and biochemical indices of the liver lesion. Biochemical investigations were carried out on 3 and 7 day of the experiment and repeated at week by intervalls. All the animals were dissected and morphological examinations of the liver were carried out. Total analysis of the results obtained of the biochemical and morphological examinations of the liver in 3 analysed groups of animals proved that the biochemical index of postalcoholic lesion of the liver was a rise in guanase activity, and not in activity aminotransferases. In the investigations of fat balance, however the increase of triglycerides and cholesterol was observed. Morphological examinations showed post-alcoholic lesions of the liver, especially intensified in animals under longlasting alcohol influence, but in reducted doses.

Published
1985

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