Search

Your search keyword '"Biglycan"' showing total 3 results
Start Over Descriptor "Biglycan" Language german
3 results on '"Biglycan"'

1. Zusammensetzung und Ausprägung der perizellulären Matrix der Bandscheibe unter dem Blickwinkel zellulärer Organisationsformen

Author

Bonnaire, FC, Bamberger, CE, Danalache, M, and Hofmann, UK

Subjects
perizelluläre Matrix, ddc: 610, Bandscheibe, Fibrillin-1, Biglycan, Medicine and health, Degeneration, Kollagen Typ VI, zelluläre Organisation, Perlecan, Osteochondrose
Abstract

Fragestellung: Die räumliche Anordnung der Chondrozyten im Gewebe ändert sich im Laufe der Entstehung und dem Verschleiß der Bandscheibe. Aus einem initial ungeordnetem Gewebe hoher Zelldichte im frühembryonalen Stadium bildet sich rasch eine höhergradige zelluläre Ordnung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
Full Text
View/download PDF

2. [A comparison of the gene expression patterns of human chondrocytes and chondrogen differentiated mesenchymal stem cells for tissue engineering]

Author

U R, Goessler, P, Bugert, K, Bieback, S, Bag, H, Sadick, H, Klüter, K, Hörmann, and F, Riedel

Subjects
Aged, 80 and over, Genetic Markers, Extracellular Matrix Proteins, Lumican, Tissue Engineering, Gene Expression Profiling, Gene Expression, Cell Differentiation, Mesenchymal Stem Cells, Chondrocytes, Chondroitin Sulfate Proteoglycans, Keratan Sulfate, Biglycan, Humans, Proteoglycans, Collagen, RNA, Messenger, Fibromodulin, Aged, Oligonucleotide Array Sequence Analysis
Abstract

Tissue engineering is a promising method for the generation of chondrogenic grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication.In this study, we investigated the expression of distinct markers during the dedifferentiation of human chondrocytes (HC) harvested during septoplasty and human mesenchymal stem cells (hMSC) from cartilage biopsies in cell culture using the microarray technique.The genes for collagen 1alpha1, 2alpha1, 3alpha1, 4alpha1, 11alpha1, biglycan, fibromodulin and lumican were activated during the dedifferentiation of the HCs, collagen 9alpha2, 9alpha3, 10alpha1 and chondroadherin were inactivated. During chondrogenic differentiation of hMSCs, the genes for collagen 3alpha1, 9alpha2, 9alpha3, 10alpha1, 11alpha1 were activated, collagen 4alpha1 and fibromodulin inactivated and the genes for Col 1alpha1, biglycan und chondroadherin constantly expressed.The genetic profile for the investigated markers in human chondrocytes generated from hMSCs resembles the profile in differentiated chondrocytes. Collagen 2alpha1, 9alpha2, 9alpha3, 10alpha1 could represent markers for the differentiation of chondrocytes, Col 1alpha1, 3alpha1 und 4alpha1, biglycan, fibromodulin and lumican markers for the dedifferentiation into a more fibroblastoid cell type.

Published
2005

3. [A comparison of the gene expression patterns of human chondrocytes and chondrogen differentiated mesenchymal stem cells for tissue engineering].

Author

Goessler UR, Bugert P, Bieback K, Bag S, Sadick H, Klüter H, Hörmann K, and Riedel F

Subjects
Aged, Aged, 80 and over, Biglycan, Chondroitin Sulfate Proteoglycans genetics, Collagen genetics, Extracellular Matrix Proteins genetics, Fibromodulin, Gene Expression Profiling, Genetic Markers genetics, Humans, Keratan Sulfate genetics, Lumican, Oligonucleotide Array Sequence Analysis, Proteoglycans genetics, RNA, Messenger genetics, Cell Differentiation genetics, Chondrocytes cytology, Chondrocytes metabolism, Gene Expression physiology, Mesenchymal Stem Cells cytology, Tissue Engineering
Abstract

Background: Tissue engineering is a promising method for the generation of chondrogenic grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication., Methods: In this study, we investigated the expression of distinct markers during the dedifferentiation of human chondrocytes (HC) harvested during septoplasty and human mesenchymal stem cells (hMSC) from cartilage biopsies in cell culture using the microarray technique., Results: The genes for collagen 1alpha1, 2alpha1, 3alpha1, 4alpha1, 11alpha1, biglycan, fibromodulin and lumican were activated during the dedifferentiation of the HCs, collagen 9alpha2, 9alpha3, 10alpha1 and chondroadherin were inactivated. During chondrogenic differentiation of hMSCs, the genes for collagen 3alpha1, 9alpha2, 9alpha3, 10alpha1, 11alpha1 were activated, collagen 4alpha1 and fibromodulin inactivated and the genes for Col 1alpha1, biglycan und chondroadherin constantly expressed., Conclusion: The genetic profile for the investigated markers in human chondrocytes generated from hMSCs resembles the profile in differentiated chondrocytes. Collagen 2alpha1, 9alpha2, 9alpha3, 10alpha1 could represent markers for the differentiation of chondrocytes, Col 1alpha1, 3alpha1 und 4alpha1, biglycan, fibromodulin and lumican markers for the dedifferentiation into a more fibroblastoid cell type.

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results