1. [Bibrocathol eye ointment is efficacious in blepharitis. Results from a randomized, double-blind, controlled clinical trial].
- Author
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Behrens-Baumann W, Niederdellmann C, Jehkul A, and Kohnen R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Catechols adverse effects, Double-Blind Method, Female, Humans, Male, Middle Aged, Ointments, Treatment Outcome, Blepharitis drug therapy, Catechols administration & dosage
- Abstract
Bibrocathol (Noviform) 5% ointment is a frequently used therapy for blepharitis. The study included 197 patients who were randomized to be treated over 2 weeks with bibrocathol or an ointment vehicle, respectively. Slit lamp examinations were performed on day 1 (baseline) and day 14 (end of study) to assess lid edema, lid erythema, debris, and pouting of Meibomian glands; patients rated their subjective complaints. Bibrocathol was superior to the control treatment in improving the sum score of the 5 scales (by 7.0 vs 4.7 points, p<0.001), especially in patients with primarily severe symptoms (by 8.3 vs 4.8, p<0.0001). Antiseptic therapy with bibrocathol eye ointment 3 times daily over 2 weeks was found to be efficacious in the treatment of acute forms of blepharitis which do not require antibiotic therapy. Bibrocathol treatment is well tolerated and safe.
- Published
- 2006
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