Search

Your search keyword '"Glatzel M"' showing total 40 results
Start Over Author "Glatzel M" Language german
40 results on '"Glatzel M"'

3. Nachweis von SARS-CoV-2-RNA in Retina und Nervus Optikus von verstorbenen COVID-19-Patienten

Author

Casagrande, M, Fitzek, A, Spitzer, M, Püschel, K, Glatzel, M, Krasemann, S, Aepfelbacher, M, Nörz, D, Lütgehetmann, M, Pfefferle, S, and Schultheiss, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die Ribonukleinsäure (RNA) des neuartigen Coronavirus (SARS-CoV-2) konnte in humanen Retinabiopsien nachgewiesen werden. Daraufhin wurden in dieser konsekutiven Fallserie Retina(RB)- und Nervus-Optikus(NOB)-Biopsien von Verstorbenen mit nachgewiesener Coronavirus-Erkrankung (COVID-19)[zum vollständigen Text gelangen Sie über die oben angegebene URL], 33. Jahrestagung der Retinologischen Gesellschaft

Published
2021
Full Text
View/download PDF

9. Abstracts der 3. Gemeinsamen Brachytherapiekonferenz SASRO/DEGRO/OEGRO

Author

Ott, O. J., Strnad, V., Pötter, R., Hammer, J., Hildebrandt, G., Resch, A., Kovács, G., Beckmann, M. W., Sauer, R., Niehoff, P., Polgar, C., Ostertag, H., Major, T., Eidtmann, H., Jonat, W., Kimmig, B., Roddiger, S. J., Kolotas, C., Kuner, R. P., Martin, T., Kurek, R., Baltas, D., Rogge, B., Kautschur, H., Hoffmann, G., Pollow, B., Kontova, M., Zamboglou, N., Ott, O., Lotter, M., Gallino, A., Mahler, F., Niewald, M., Jafari, F., Hennen, B., Wisser, L., Fleckenstein, J., Rübe, Ch., Böhm, M., Micke, O., Wagner, W., Schäfer, U., Willich, N., Greiner, R. H., Pallas, A., Pajic, B., Collen, T., Meurer, N., Töpfer, M., Ries, G., Leutloff, U., Frei, S., Warszawski, A., Baumann, R., Möller, T., Niedermeyer, J., Karstens, J. H., Gripp, S., Muskalla, K., Pulte, T., Ohmann, C., Röddiger, S., Dannenberg, T., Tunn, U. W., Dimopoulos, J., Schard, G., Kirisits, C., Lang, S., Goldner, G., Wachter, S., Wachter-Gerstner, N., Helbich, T., Weise, C., Bendel, M., Kocher, M., Müller, R.-P., Engelmann, U., Aebersold, D. M., Isaak, B., Vetterli, D., Kemmerling, L., Thalmann, G., Behrensmeier, F., Mini, R., Baier, K., Wulf, J., Nürnberg, N., Egberts, J., Galalae, R., Maurer, U., Maurer, G., Lang, K., Zumbé, J., Block, T., Czempiel, H., Machtens, S., Ponholzer, A., Riedl, A., Oismüller, R., Somay, C., Hawliczek, R., Maier, U., Madersbacher, S., Hoinkis, C., Winkler, C., Lehmann, D., Hakenberg, O., Herrmann, T., Messer, P. M., Gottfried, H.-W., Schneider, E., Röttinger, E. M., Haverkamp, U., Prümer, B. A., Krause, K., Tschuschke, C., Blumberg, J., Benkel, P., Fischedick, A. R., Geiger, M. H., Hoffmann, T. C., Reible, M., Meyer-Venter, R., Plümpe, A., Bund, J., Dreikorn, K., Staar, S., Horn, G., Zimmermann, J. S., Pfeiffer, D., Tauber, R., Bruns, T., Osieka, R., Blumstein, N. M., Schmidt, W., Büchler, F., Prikler, L., Seelentag, W., Koch, K., Haker, H., König, F., Oesterwitz, H., Schütz, R., Stahl, H., Ullmann, A., Sztankay, A., Rachbauer, F., Kreczy, A., Sununu, T., Bach, C., Nogler, M., Krismer, M., Eichberger, P., Schiestl, B., Lukas, P., Wolf, A., Hänsgen, G., Dunst, J., Utzig, D., Knocke-Abulesz, T. H., Baldass, M., Kucera, H., Weitmann, H. D., Waldhäusl, C., Nechvile, E., Knocke, T.-H., Georg, D., Krause, U., Fröhlich, D., Glatzel, M., Büntzel, J., Schröder, D., Küttner, K., Pfreundnerx, L., Willner, J., Bratengeier, K., Schwager, K., Hoppe, F., Schwab, F., Sauer, O., Flentje, M., Tselis, N., Schneider, O., Stückle, C. A., Adamietz, I. A., Weitman, H. D., Tepel, J., Schmid, A., Kohr, P., Kremer, B., Moh’d, Suleiman, Frey, J. G., Tschopp, J. M., Bieri, S., Jeszensky, D., Liebsch, N., Seelentag, W. W., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Blochberger, P., Wächtler, M., Kaulich, T. W., Zurheide, J., Haug, T., Nüsslin, F., Bamberg, M., Curschmann, J., Kranzbühler, H., Greiner, R., Cossmann, P. H., Caversaccio, M., Pappas, I., and Nolte, L. P.

Published
2004
Full Text
View/download PDF

10. DEGRO 2004: 10. Jahreskongress der Deutschen Gesellschaft für Radioonkologie

Author

Wendt, Thomas G., Gademann, G., Pambor, C., Grießbach, I., von Specht, H., Martin, T., Baltas, D., Kurek, R., Röddiger, S., Tunn, U. W., Zamboglou, N., Eich, H. T., Staar, S., Gossmann, A., Hansemann, K., Semrau, R., Skripnitchenko, R., Diehl, V., Müller, R.-P., Sehlen, S., Willich, N., Rühl, U., Lukas, P., Dühmke, E., Engel, K., Tabbert, E., Bolck, M., Knaack, S., Annweiler, H., Krempien, R., Hoppe, H., Harms, W., Daeuber, S., Schorr, O., Treiber, M., Debus, J., Alber, M., Paulsen, F., Birkner, M., Bakai, A., Belka, C., Budach, W., Grosser, K.-H., Kramer, R., Kober, B., Reinert, M., Schneider, P., Hertel, A., Feldmann, H., Csere, P., Hoinkis, C., Rothe, G., Zahn, P., Alheit, H., Cavanaugh, S. X., Kupelian, P., Reddy, C., Pollock, B., Fuss, M., Roeddiger, S., Dannenberg, T., Rogge, B., Drechsler, D., Herrmann, T., Alberti, W., Schwarz, R., Graefen, M., Krüll, A., Rudat, V., Huland, H., Fehr, C., Baum, C., Glocker, S., Nüsslin, F., Heil, T., Lemnitzer, H., Knips, M., Baumgart, O., Thiem, W., Kloetzer, K.-H., Hoffmann, L., Neu, B., Hültenschmidt, B., Sautter-Bihl, M.-L., Micke, O., Seegenschmiedt, M. H., Köppen, D., Klautke, G., Fietkau, R., Schultze, J., Schlichting, G., Koltze, H., Kimmig, B., Glatzel, M., Fröhlich, D., Bäsecke, S., Krauß, A., Strauß, D., Buth, K.-J., Böhme, R., Oehler, W., Bottke, D., Keilholz, U., Heufelder, K., Wiegel, T., Hinkelbein, W., Rödel, C., Papadopoulos, T., Munnes, M., Wirtz, R., Sauer, R., Rödel, F., Lubgan, D., Distel, L., Grabenbauer, G. G., Sak, A., Stüben, G., Pöttgen, C., Grehl, S., Stuschke, M., Müller, K., Pfaffendorf, C., Mayerhofer, A., Köhn, F. M., Ring, J., van Beuningen, D., Meineke, V., Neubauer, S., Keller, U., Wittlinger, M., Riesenbeck, D., Greve, B., Exeler, R., Ibrahim, M., Liebscher, C., Severin, E., Ott, O., Pötter, R., Hammer, J., Hildebrandt, G., Beckmann, M. W., Strnad, V., Fehlauer, F., Tribius, S., Bajrovic, A., Höller, U., Rades, D., Warszawski, A., Baumann, R., Madry-Gevecke, B., Karstens, J. H., Grehn, C., Hensley, F., Berns, C., Wannenmacher, M., Semrau, S., Reimer, T., Gerber, B., Ketterer, P., Koepcke, E., Hänsgen, G., Strauß, H. G., Dunst, J., Füller, J., Kalb, S., Wendt, T., Weitmann, H. D., Waldhäusl, C., Knocke, T.-H., Lamprecht, U., Classen, J., Kaulich, T. W., Aydeniz, B., Bamberg, M., Wiezorek, T., Banz, N., Salz, H., Scheithauer, M., Schwedas, M., Lutterbach, J., Bartelt, S., Frommhold, H., Lambert, J., Hornung, D., Swiderski, S., Walke, M., Siefert, A., Pöllinger, B., Krimmel, K., Schaffer, M., Koelbl, O., Bratengeier, K., Vordermark, D., Flentje, M., Hero, B., Berthold, F., Combs, S. E., Gutwein, S., Schulz-Ertner, D., van Kampen, M., Thilmann, C., Kocher, M., Kunze, S., Schild, S., Ikezaki, K., Müller, B., Sieber, R., Weiß, C., Wolf, I., Wenz, F., Weber, K.-J., Schäfer, J., Engling, A., Laufs, S., Veldwijk, M. R., Milanovic, D., Fleckenstein, K., Zeller, W., Fruehauf, S., Herskind, C., Weinmann, M., Jendrossek, V., Rübe, C., Appold, S., Kusche, S., Hölscher, T., Brüchner, K., Geyer, P., Baumann, M., Kumpf, R., Zimmermann, F., Schill, S., Geinitz, H., Nieder, C., Jeremic, B., Molls, M., Liesenfeld, S., Petrat, H., Hesselmann, S., Schäfer, U., Bruns, F., Horst, E., Wilkowski, R., Assmann, G., Nolte, A., Diebold, J., Löhrs, U., Fritz, P., Hans-Jürgen, K., Mühlnickel, W., Bach, P., Wahlers, B., Kraus, H.-J., Wulf, J., Hädinger, U., Baier, K., Krieger, T., Müller, G., Hof, H., Herfarth, K., Brunner, T., Hahn, S. M., Schreiber, F. S., Rustgi, A. K., McKenna, W. G., Bernhard, E. J., Guckenberger, M., Meyer, K., Willner, J., Schmidt, M., Kolb, M., Li, M., Gong, P., Abdollahi, A., Trinh, T., Huber, P. E., Christiansen, H., Saile, B., Neubauer-Saile, K., Tippelt, S., Rave-Fränk, M., Hermann, R. M., Dudas, J., Hess, C. F., Schmidberger, H., Ramadori, G., Andratschke, N., Price, R., Ang, K.-K., Schwarz, S., Kulka, U., Busch, M., Schlenger, L., Bohsung, J., Eichwurzel, I., Matnjani, G., Sandrock, D., Richter, M., Wurm, R., Budach, V., Feussner, A., Gellermann, J., Jordan, A., Scholz, R., Gneveckow, U., Maier-Hauff, K., Ullrich, R., Wust, P., Felix, R., Waldöfner, N., Seebass, M., Ochel, H.-J., Dani, A., Varkonyi, A., Osvath, M., Szasz, A., Messer, P. M., Blumstein, N. M., Gottfried, H.-W., Schneider, E., Reske, S. N., Röttinger, E. M., Grosu, A.-L., Franz, M., Stärk, S., Weber, W., Heintz, M., Indenkämpen, F., Beyer, T., Lübcke, W., Levegrün, S., Hayen, J., Czech, N., Mbarek, B., Köster, R., Thurmann, H., Todorovic, M., Schuchert, A., Meinertz, T., Münzel, T., Grundtke, H., Hornig, B., Hehr, T., Dilcher, C., Chan, R. C., Mintz, G. S., Kotani, J.-I., Shah, V. M., Canos, D. A., Weissman, N. J., Waksman, R., Wolfram, R., Bürger, B., Schrappe, M., Timmermann, B., Lomax, A., Goitein, G., Schuck, A., Mattke, A., Int-Veen, C., Brecht, I., Bernhard, S., Treuner, J., Koscielniak, E., Heinze, F., Kuhlen, M., von Schorlemer, I., Ahrens, S., Hunold, A., Könemann, S., Winkelmann, W., Jürgens, H., Gerstein, J., Polivka, B., Sykora, K.-W., Bremer, M., Thamm, R., Höpfner, C., Gumprecht, H., Jäger, R., Leonardi, M. A., Frank, A. M., Trappe, A. E., Lumenta, C. B., Östreicher, E., Pinsker, K., Müller, A., Fauser, C., Arnold, W., Henzel, M., Groß, M. W., Engenhart-Cabillic, R., Schüller, P., Palkovic, S., Schröder, J., Wassmann, H., Block, A., Bauer, R., Keffel, F.-W., Theophil, B., Wisser, L., Rogger, M., Niewald, M., van Lengen, V., Mathias, K., Welzel, G., Bohrer, M., Steinvorth, S., Schleußner, C., Leppert, K., Röhrig, B., Strauß, B., van Oorschot, B., Köhler, N., Anselm, R., Winzer, A., Schneider, T., Koch, U., Schönekaes, K., Mücke, R., Büntzel, J., Kisters, K., Scholz, C., Keller, M., Winkler, C., Prause, N., Busch, R., Roth, S., Haas, I., Willers, R., Schultze-Mosgau, S., Wiltfang, J., Kessler, P., Neukam, F. W., Röper, B., Nüse, N., Auer, F., Melzner, W., Geiger, M., Lotter, M., Kuhnt, T., Müller, A. C., Jirsak, N., Gernhardt, C., Schaller, H.-G., Al-Nawas, B., Klein, M. O., Ludwig, C., Körholz, J., Grötz, K. A., Huppers, K., Kunkel, M., Olschewski, T., Bajor, K., Lang, B., Lang, E., Kraus-Tiefenbacher, U., Hofheinz, R., von Gerstenberg-Helldorf, B., Willeke, F., Hochhaus, A., Roebel, M., Oertel, S., Riedl, S., Buechler, M., Foitzik, T., Ludwig, K., Klar, E., Meyer, A., Meier zu Eissen, J., Schwab, D., Meyer, T., Höcht, S., Siegmann, A., Sieker, F., Pigorsch, S., Milicic, B., Acimovic, L., Milisavljevic, S., Radosavljevic-Asic, G., Presselt, N., Baum, R. P., Treutler, D., Bonnet, R., Schmücking, M., Sammour, D., Fink, T., Ficker, J., Pradier, O., Lederer, K., Weiss, E., Hille, A., Welz, S., Sepe, S., Friedel, G., Spengler, W., Susanne, E., Kölbl, O., Hoffmann, W., Wörmann, B., Günther, A., Becker-Schiebe, M., Güttler, J., Schul, C., Nitsche, M., Körner, M. K., Oppenkowski, R., Guntrum, F., Malaimare, L., Raub, M., Schöfl, C., Averbeck, T., Hacker, I., Blank, H., Böhme, C., Imhoff, D., Eberlein, K., Weidauer, S., Böttcher, H. D., Edler, L., Tatagiba, M., Molina, H., Ostertag, C., Milker-Zabel, S., Zabel, A., Schlegel, W., Hartmann, A., Wildfang, I., Kleinert, G., Hamm, K., Reuschel, W., Wehrmann, R., Kneschaurek, P., Münter, M. W., Nikoghosyan, A., Didinger, B., Nill, S., Rhein, B., Küstner, D., Schalldach, U., Eßer, D., Göbel, H., Wördehoff, H., Pachmann, S., Hollenhorst, H., Dederer, K., Evers, C., Lamprecht, J., Dastbaz, A., Schick, B., Fleckenstein, J., Plinkert, P. K., Rübe, Chr., Merz, T., Sommer, B., Mencl, A., Ghilescu, V., Astner, S., Martin, A., Momm, F., Volegova-Neher, N. J., Schulte-Mönting, J., Guttenberger, R., Buchali, A., Blank, E., Sidow, D., Huhnt, W., Gorbatov, T., Heinecke, A., Beckmann, G., Bentia, A.-M., Schmitz, H., Spahn, U., Heyl, V., Prott, P.-J., Galalae, R., Schneider, R., Voith, C., Scheda, A., Hermann, B., Bauer, L., Melchert, F., Kröger, N., Grüneisen, A., Jänicke, F., Zander, A., Zuna, I., Schlöcker, I., Wagner, K., John, E., Dörk, T., Lochhas, G., Houf, M., Lorenz, D., Link, K.-H., Prott, F.-J., Thoma, M., Schauer, R., Heinemann, V., Romano, M., Reiner, M., Quanz, A., Oppitz, U., Bahrehmand, R., Tine, M., Naszaly, A., Patonay, P., Mayer, Á., Markert, K., Mai, S.-K., Lohr, F., Dobler, B., Pinkawa, M., Fischedick, K., Treusacher, P., Cengiz, D., Mager, R., Borchers, H., Jakse, G., Eble, M. J., Asadpour, B., Krenkel, B., Holy, R., Kaplan, Y., Block, T., Czempiel, H., Haverkamp, U., Prümer, B., Christian, T., Benkel, P., Weber, C., Gruber, S., Reimann, P., Blumberg, J., Krause, K., Fischedick, A.-R., Kaube, K., Steckler, K., Henzel, B., Licht, N., Loch, T., Krystek, A., Lilienthal, A., Alfia, H., Claßen, J., Spillner, P., Knutzen, B., Souchon, R., Schulz, I., Grüschow, K., Küchenmeister, U., Vogel, H., Wolff, D., Ramm, U., Licner, J., Rudolf, F., Moog, J., Rahl, C. G., Mose, S., Vorwerk, H., Weiß, E., Engert, A., Seufert, I., Schwab, F., Dahlke, J., Zabelina, T., Krüger, W., Kabisch, H., Platz, V., Wolf, J., Pfistner, B., Stieltjes, B., Wilhelm, T., Schmuecking, M., Junker, K., Treutier, D., Schneider, C. P., Leonhardi, J., Niesen, A., Hoeffken, K., Schmidt, A., Mueller, K.-M., Schmid, I., Lehmann, K., Blumstein, C. G., Kreienberg, R., Freudenberg, L., Kühl, H., Stahl, M., Elo, B., Erichsen, P., Stattaus, H., Welzel, T., Mende, U., Heiland, S., Salter, B. J., Schmid, R., Stratakis, D., Huber, R. M., Haferanke, J., Zöller, N., Henke, M., Lorenzen, J., Grzyska, B., Kuhlmey, A., Adam, G., Hamelmann, V., Bölling, T., Job, H., Panke, J. E., Feyer, P., Püttmann, S., Siekmeyer, B., Jung, H., Gagel, B., Militz, U., Piroth, M., Schmachtenberg, A., Hoelscher, T., Verfaillie, C., Kaminski, B., Lücke, E., Mörtel, H., Eyrich, W., Fritsch, M., Georgi, J.-C., Plathow, C., Zieher, H., Kiessling, F., Peschke, P., Kauczor, H.-U., Licher, J., Schneider, O., Henschler, R., Seidel, C., Kolkmeyer, A., Nguyen, T. P., Janke, K., Michaelis, M., Bischof, M., Stoffregen, C., Lipson, K., Weber, K., Ehemann, V., Jürgen, D., Achanta, P., Thompson, K., Martinez, J. L., Körschgen, T., Pakala, R., Pinnow, E., Hellinga, D., O’Tio, F., Katzer, A., Kaffer, A., Kuechler, A., Steinkirchner, S., Dettmar, N., Cordes, N., Frick, S., Kappler, M., Taubert, H., Bartel, F., Schmidt, H., Bache, M., Frühauf, S., Wenk, T., Litzenberger, K., Erren, M., van Valen, F., Liu, L., Yang, K., Palm, J., Püsken, M., Behe, M., Behr, T. M., Marini, P., Johne, A., Claussen, U., Liehr, T., Steil, V., Moustakis, C., Griessbach, I., Oettel, A., Schaal, C., Reinhold, M., Strasssmann, G., Braun, I., Vacha, P., Richter, D., Osterham, T., Wolf, P., Guenther, G., Miemietz, M., Lazaridis, E. A., Forthuber, B., Sure, M., Klein, J., Saleske, H., Riedel, T., Hirnle, P., Horstmann, G., Schoepgens, H., Van Eck, A., Bundschuh, O., Van Oosterhut, A., Xydis, K., Theodorou, K., Kappas, C., Zurheide, J., Fridtjof, N., Ganswindt, U., Weidner, N., Buchgeister, M., Weigel, B., Müller, S. B., Glashörster, M., Weining, C., Hentschel, B., Sauer, O. A., Kleen, W., Beck, J., Lehmann, D., Ley, S., Fink, C., Puderbach, M., Hosch, W., Schmähl, A., Jung, K., Stoßberg, A., Rolf, E., Damrau, M., Oetzel, D., Maurer, U., Maurer, G., Lang, K., Zumbe, J., Hahm, D., Fees, H., Robrandt, B., Melcher, U., Niemeyer, M., Mondry, A., Kanellopoulos-Niemeyer, V., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Schiebe, M., Pinkert, U., Piasswilm, L., Pohl, F., Garbe, S., Wolf, K., Nour, Y., Barwig, P., Trog, D., Schäfer, C., Herbst, M., Dietl, B., Cartes, M., Schroeder, F., Sigingan-Tek, G., Feierabend, R., Theden, S., Schlieck, A., Gotthardt, M., Glowalla, U., Kremp, S., Hamid, O., Riefenstahl, N., Michaelis, B., Schaal, G., Liebermeister, E., Niewöhner-Desbordes, U., Kowalski, M., Franz, N., Stahl, W., Baumbach, C., Thale, J., Wagner, W., Justus, B., Huston, A. L., Seaborn, R., Rai, P., Rha, S.-W., Sakas, G., Wesarg, S., Zogal, P., Schwald, B., Seibert, H., Berndt-Skorka, R., Seifert, G., Schoenekaes, K., Bilecen, C., Ito, W., Matschuck, G., and Isik, D.

Published
2004
Full Text
View/download PDF

11. COVID-19: Auswirkungen auf das zentrale und periphere Nervensystem.

Author

Ritschel, N., Radbruch, H., Herden, C., Schneider, N., Dittmayer, C., Franz, J., Thomas, C., Silva Boos, G., Pagenstecher, A., Schulz-Schaeffer, W., Stadelmann, C., Glatzel, M., Heppner, F. L., Weis, J., Sohrabi, K., Schänzer, A., Németh, A., Acker, T., and DGNN-Taskforce „CNS-COVID19"

Abstract

Copyright of Der Pathologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
Full Text
View/download PDF

12. Erratum zu: Strahlentherapie und Onkologie, Volume 186 (No. 1)

Author

Dittmann, K., Mayer, C., Rodemann, H. P., Mücke, R., Seegenschmiedt, M. H., Heyd, R., Schäfer, U., Prott, F-J, Glatzel, M., Micke, O., Adamietz, B., Schulz-Wendtland, R., Alibek, S., Uder, M., Sauer, R., Ott, O., Keilholz, L., Heyd, R., Dorn, A.P., Herkströter, M., Rödel, C., Müller-Schimpfle, M., Fraunholz, I., Wolff, H.A., Gaedcke, J., Jung, K., Hermann, R.M., Rothe, H., Schirmer, M., Liersch, T., Herrmann, M.K.A., Hennies, S., Rave-Fränk, M., Hess, C.F., Christiansen, H., Mizumoto, M., Nakayama, H., Tokita, M., Sugahara, S., Hashii, H., Sakae, T., Tsuboi, K., Sakurai, H., Tokuuye, K., Geinitz, H., Thamm, R., Scholz, C., Heinrich, C., Prause, N., Kerndl, S., Keller, M., Busch, R., Molls, M., and Zimmermann, F.B.

Published
2010
Full Text
View/download PDF

13. Impfung und Schütteltrauma.

Author

Matschke, J., Sperhake, J.-P., Püschel, K., and Glatzel, M.

Abstract

Copyright of Rechtsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
Full Text
View/download PDF

22. Prophylaxe der strahleninduzierten Diarrhö durch Smektit. Ergebnisse einer doppelblind randomisierten, plazebokontrollierten Multicenterstudie.

Author

Hombrink, J, Fröhlich, D, Glatzel, M, Krauss, A, Thiel, H J, Meier, J, Hamann, D, Mücke, R, Glaser, F H, and Köst, S

Abstract

Purpose: Diarrhea and abdominal pain are well-known side effects abdominal or pelvic of radiation therapy that may lead to interruption of treatment in serious cases. In recent trials the silicate smectite has proven a promising drug in the prophylaxis of these adverse events. The presented trial aimed at the verification of earlier studies and the evaluation of a dose-effect relationship.Patients and Methods: Between April 1994 and May 1995, a total of 176 patients obtaining radiotherapy of the pelvis or the abdomen were evaluated in a double-blind, randomized placebo-controlled investigation regarding the prophylactic effect of smectite (= Colina) against radiotherapy-induced diarrhea. During the whole period of radiotherapy 85 patients obtained 2 x 6 g smectite daily and 91 patients received 2 x 6 g placebo. The primary end point of the analysis was the time to the first appearance of diarrhea (> or = 3 pappy stools).Results: All 176 patients were evaluated according to an intent-to-treat analysis. There was no significant difference between the prophylactic effects of smectite and placebo. For an explorative post-hoc analysis the total study group was split up into 2 subgroups, one with an irradiated small bowel volume < or = 837.5 ml, the other with a small bowel volume > 837.5 ml (median); the analysis indicated that the first subgroup showed a benefit for the smectite-treated patients in contrast to the placebo treatment (32 vs. 18 calendar days to the first appearance of diarrhea). This benefit was statistically not significant.Conclusion: Prophylactic application of smectite during irradiation of the pelvis and the abdomen can delay the development of radiotherapy-induced diarrhea, a statistical significance could not be verified neither in the total study group nor in the post-hoc subgroup analysis. [ABSTRACT FROM AUTHOR]

Published
2000

23. [The unusual mimicker of a polymyositis].

Author

Jendrek ST, Glatzel M, Pauli D, Schinke S, Humrich JY, Lamprecht P, and Riemekasten G

Subjects
Cyclophosphamide therapeutic use, Cyclosporine therapeutic use, Glucocorticoids therapeutic use, Humans, Myositis diagnosis, Polymyositis diagnosis, Polymyositis drug therapy, Polymyositis pathology
Abstract

This article describes a hantavirus-associated pronounced myositis as a rare differential diagnosis to polymyositis. The literature on the pathogenesis of hantavirus disease discusses less a direct viral cytopathology but more a secondary immune dysregulation with induction of a capillary leak. This article describes for the first time a case of successful treatment of protracted hantavirus myositis using high-dose glucocorticoids and cyclophosphamide, followed by ciclosporin and MTX., (© 2022. The Author(s).)

Published
2022
Full Text
View/download PDF

24. [COVID-19 and the central and peripheral nervous system].

Author

Ritschel N, Radbruch H, Herden C, Schneider N, Dittmayer C, Franz J, Thomas C, Silva Boos G, Pagenstecher A, Schulz-Schaeffer W, Stadelmann C, Glatzel M, Heppner FL, Weis J, Sohrabi K, Schänzer A, Németh A, and Acker T

Subjects
Germany, Humans, Pandemics, Peripheral Nervous System, SARS-CoV-2, COVID-19
Abstract

The health effects of coronavirus disease 2019 (COVID-19) caused by the infection of SARS-CoV‑2 (severe acute respiratory syndrome coronavirus 2) are becoming increasingly clear as the pandemic spreads. In addition to the lungs, other organs are also affected, which can significantly influence morbidity and mortality. In particular, neurological symptoms involving the central nervous system can lead to acute or long-term consequences. The mechanisms of this neuropathogenesis of SARS-CoV‑2 infection and its relation to acute and chronic neurological symptoms are the subject of current studies investigating a potential direct and indirect viral infection of the nervous system. The following review summarizes the current status of neuropathological manifestations, molecular pathogenesis, possible infection pathways in the nervous system, and systemic effects. In addition, an overview of the Germany-wide CNS-COVID19 registry and collaborations is presented, which should contribute to a better understanding of the neurological symptoms of COVID-19.

Published
2021
Full Text
View/download PDF

25. [Radiotherapy in painful gonarthrosis. Results of a national patterns-of-care study].

Author

Mücke R, Seegenschmiedt MH, Heyd R, Schäfer U, Prott FJ, Glatzel M, and Micke O

Subjects
Cohort Studies, Combined Modality Therapy, Germany, Humans, Multicenter Studies as Topic, Pain Measurement radiation effects, Quality Assurance, Health Care statistics & numerical data, Radiotherapy Dosage, Referral and Consultation statistics & numerical data, Retreatment, Surveys and Questionnaires, Treatment Outcome, Arthralgia radiotherapy, Osteoarthritis, Knee radiotherapy, Practice Patterns, Physicians' statistics & numerical data
Abstract

Background and Purpose: After a patterns-of-care study (PCS) in 2003/2004 addressing benign disorders in general, the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD) conducted several multicenter cohort studies including the use of radiotherapy (RT) in painful gonarthrosis (GNA)., Material and Methods: From 2006 to 2008, a PCS for GNA was conducted in all German RT institutions using a standardized structured questionnaire. Patient accrual, patient number, pretreatment, pain record, treatment indications, RT technique, and target volume concepts for painful GNA were assessed. In addition, the long-term functional and subjective outcomes were evaluated., Results: 238/248 institutions (95.9%) returned the questionnaire: 50 (21%) reported no clinical experience with RT in GNA, while 188 (79%) institutions treated 4,544 patients annually (median 15; range one to 846 cases per institution). Indications for treatment were acute pain symptoms in 18.9%, chronic pain in 95.3%, and treatment-refractory pain in 81.1%. The median total dose was 6 Gy (range 3-12 Gy), with a median single dose of 1 Gy (0.25-3 Gy). 40.4% of the institutions applied two fractions and 51.4% three fractions weekly. RT was delivered with orthovoltage units (25%), linear accelerators (79.6%), and cobalt-60 units (8.3%). 42 institutions evaluated the long-term clinical outcome in a total of 5,069 cases. Median pain reduction for at least 3 months was reported in 60% (5-100%), median pain reduction for at least 12 months in 40% (10-100%), and median persistent pain reduction in 27.8% (10-85%) of the treated patients. In 30% of patients (7-100%), a second RT series was applied for inadequate pain response or early pain recurrence. No radiogenic acute or chronic side effects were observed., Conclusion: This PCS comprises the largest number of cases reported for RT in painful and refractory GNA. Despite variations in daily RT practice, high response and low toxicity for this treatment in a very large number of painful and refractory GNA cases renders low-dose RT an effective conservative therapy which can be applied prior to surgical procedures.

Published
2010
Full Text
View/download PDF

26. [Comparative analysis of patient-centered outcome of total hip and knee arthroplasty].

Author

Wollmerstedt N, Glatzel M, Kirschner S, Schneider J, Faller H, and König A

Subjects
Adult, Aged, Female, Germany epidemiology, Humans, Male, Middle Aged, Osteoarthritis, Hip diagnosis, Osteoarthritis, Knee diagnosis, Outcome Assessment, Health Care, Prognosis, Treatment Outcome, Arthroplasty, Replacement, Hip statistics & numerical data, Arthroplasty, Replacement, Knee statistics & numerical data, Osteoarthritis, Hip epidemiology, Osteoarthritis, Hip surgery, Osteoarthritis, Knee epidemiology, Osteoarthritis, Knee surgery, Recovery of Function
Abstract

Aim: The aim of the present study was a comparative investigation of the functional improvement reported by patients suffering from primary osteoarthritis of the knee or hip undergoing total joint replacement and assessed at 3 months., Method: In a prospective, controlled clinical trial, 56 patients with primary osteoarthritis of the hip and 59 patients with primary osteoarthritis of the knee undergoing total joint replacement were assessed at two measuring times (day of admission = t1 and 3-month follow-up = t2) using the XSMFA-D (Extra Short Musculoskeletal Function Assessment Questionnaire--German version), WOMAC (Western Ontario and McMasters Universities) arthrosis index and FFb-H OA (Function Assessment Questionnaire Hannover Osteoarthritis). The statistical analysis included effect sizes as standardised response mean, t-test and covariance analysis., Results: Both groups of patients demonstrated significant improvements of the musculoskeletal functions measured. The effect sizes between baseline scores and 3-month follow-up scores range from 0.4 to 2.0 and can be considered as large effects. The covariance analysis showed significant differences between patients with osteoarthritis of the hip and knee for almost every score examined. Patients with hip replacement showed large improvements. A significant influence of the presurgery baseline score on the 3-month score was found consistently. Further analysis showed that patients with medium or strong degrees of disability according to the Function index of the XSMFA-D showed the strongest effects of change at 3 months. However, their scores at t2 were less than the scores of the less disabled patients at t1., Conclusion: We conclude that patients with hip replacement show more improvement 3 months after the surgery than patients with knee replacement. Furthermore, it was seen that patients who were more disabled before surgery achieved more improvement than the less-disabled patients. However, they did not achieve the level of the less disabled patients. Thus, the recommendation that total joint replacement should be performed as late as possible should be reviewed.

Published
2006
Full Text
View/download PDF

27. [Evaluation of the Extra Short Musculoskeletal Function Assessment questionnaire XSMFA-D in patients with musculoskeletal disorders and surgical or medical in-patient treatment].

Author

Wollmerstedt N, Faller H, Ackermann H, Schneider J, Glatzel M, Kirschner S, and König A

Subjects
Activities of Daily Living psychology, Adult, Aged, Disability Evaluation, Female, Humans, Male, Middle Aged, Psychometrics, Reproducibility of Results, Statistics as Topic, Activities of Daily Living classification, Arthritis, Rheumatoid rehabilitation, Osteoarthritis, Hip rehabilitation, Osteoarthritis, Knee rehabilitation, Rotator Cuff Injuries, Shoulder Impingement Syndrome rehabilitation, Surveys and Questionnaires standards
Abstract

Aim: The present study had the objective of evaluating the psychometric characteristics of the shortened 16-item version of the German Short Musculoskeletal Function Assessment questionnaire (XSMFA-D), which was designed for routine assessment of functional capacity in patients with various orthopaedic disorders treated either surgically or medically., Methods: A total of 382 patients from seven different samples with either osteoarthritis of the knee, osteoarthritis of the hip, rheumatoid arthritis or rotator cuff tear treated either in surgical hospitals or rehabilitation settings were assessed both before and after treatment. The XSMFA-D was compared with both questionnaires measuring similar constructs and widely accepted indicators of health status in musculoskeletal disorders. Psychometric characteristics were computed., Results: The internal consistency (Cronbach's alpha) exceeded 0.90 in most cases for the function index and was between 0.80 and 0.90 in most cases for the bother index of the XSMFA-D. Retest-reliability was between 0.80 and 0.95 for the function index and between 0.60 and 0.92 for the bother index. Correlations between the XSMFA-D subscales and the other questionnaires were substantial, showing construct validity. Criterion validity was also demonstrated as significant relationships with accepted external parameters such as function tests, judgements by physicians, pain self-ratings by patients and disease severity scores were found. Sensitivity to change was as high as for the other assessment instruments used in this study., Conclusions: The XSMFA-D, a very short assessment instrument, proved to be practical, reliable, valid and sensitive to change among the various patient samples studied. It may be recommended for the assessment of patients' state as well as the evaluation of treatments.

Published
2006
Full Text
View/download PDF

28. [Not Available].

Author

Wendt TG, Gademann G, Pambor C, Grießbach I, von Specht H, Martin T, Baltas D, Kurek R, Röddiger S, Tunn UW, Zamboglou N, Eich HT, Staar S, Gossmann A, Hansemann K, Semrau R, Skripnitchenko R, Diehl V, Müller RP, Sehlen S, Willich N, Rühl U, Lukas P, Dühmke E, Engel K, Tabbert E, Bolck M, Knaack S, Annweiler H, Krempien R, Hoppe H, Harms W, Daeuber S, Schorr O, Treiber M, Debus J, Alber M, Paulsen F, Birkner M, Bakai A, Belka C, Budach W, Grosser KH, Kramer R, Kober B, Reinert M, Schneider P, Hertel A, Feldmann H, Csere P, Hoinkis C, Rothe G, Zahn P, Alheit H, Cavanaugh SX, Kupelian P, Reddy C, Pollock B, Fuss M, Roeddiger S, Dannenberg T, Rogge B, Drechsler D, Herrmann T, Alberti W, Schwarz R, Graefen M, Krüll A, Rudat V, Huland H, Fehr C, Baum C, Glocker S, Nüsslin F, Heil T, Lemnitzer H, Knips M, Baumgart O, Thiem W, Kloetzer KH, Hoffmann L, Neu B, Hültenschmidt B, Sautter-Bihl ML, Micke O, Seegenschmiedt MH, Köppen D, Klautke G, Fietkau R, Schultze J, Schlichting G, Koltze H, Kimmig B, Glatzel M, Fröhlich D, Bäsecke S, Krauß A, Strauß D, Buth KJ, Böhme R, Oehler W, Bottke D, Keilholz U, Heufelder K, Wiegel T, Hinkelbein W, Rödel C, Papadopoulos T, Munnes M, Wirtz R, Sauer R, Rödel F, Lubgan D, Distel L, Grabenbauer GG, Sak A, Stüben G, Pöttgen C, Grehl S, Stuschke M, Müller K, Pfaffendorf C, Mayerhofer A, Köhn FM, Ring J, van Beuningen D, Meineke V, Neubauer S, Keller U, Wittlinger M, Riesenbeck D, Greve B, Exeler R, Ibrahim M, Liebscher C, Severin E, Ott O, Pötter R, Hammer J, Hildebrandt G, Beckmann MW, Strnad V, Fehlauer F, Tribius S, Bajrovic A, Höller U, Rades D, Warszawski A, Baumann R, Madry-Gevecke B, Karstens JH, Grehn C, Hensley F, Berns C, Wannenmacher M, Semrau S, Reimer T, Gerber B, Ketterer P, Koepcke E, Hänsgen G, Strauß HG, Dunst J, Füller J, Kalb S, Wendt T, Weitmann HD, Waldhäusl C, Knocke TH, Lamprecht U, Classen J, Kaulich TW, Aydeniz B, Bamberg M, Wiezorek T, Banz N, Salz H, Scheithauer M, Schwedas M, Lutterbach J, Bartelt S, Frommhold H, Lambert J, Hornung D, Swiderski S, Walke M, Siefert A, Pöllinger B, Krimmel K, Schaffer M, Koelbl O, Bratengeier K, Vordermark D, Flentje M, Hero B, Berthold F, Combs SE, Gutwein S, Schulz-Ertner D, van Kampen M, Thilmann C, Kocher M, Kunze S, Schild S, Ikezaki K, Müller B, Sieber R, Weiß C, Wolf I, Wenz F, Weber KJ, Schäfer J, Engling A, Laufs S, Veldwijk MR, Milanovic D, Fleckenstein K, Zeller W, Fruehauf S, Herskind C, Weinmann M, Jendrossek V, Rübe C, Appold S, Kusche S, Hölscher T, Brüchner K, Geyer P, Baumann M, Kumpf R, Zimmermann F, Schill S, Geinitz H, Nieder C, Jeremic B, Molls M, Liesenfeld S, Petrat H, Hesselmann S, Schäfer U, Bruns F, Horst E, Wilkowski R, Assmann G, Nolte A, Diebold J, Löhrs U, Fritz P, Hans-Jürgen K, Mühlnickel W, Bach P, Wahlers B, Kraus HJ, Wulf J, Hädinger U, Baier K, Krieger T, Müller G, Hof H, Herfarth K, Brunner T, Hahn SM, Schreiber FS, Rustgi AK, McKenna WG, Bernhard EJ, Guckenberger M, Meyer K, Willner J, Schmidt M, Kolb M, Li M, Gong P, Abdollahi A, Trinh T, Huber PE, Christiansen H, Saile B, Neubauer-Saile K, Tippelt S, Rave-Fränk M, Hermann RM, Dudas J, Hess CF, Schmidberger H, Ramadori G, Andratschke N, Price R, Ang KK, Schwarz S, Kulka U, Busch M, Schlenger L, Bohsung J, Eichwurzel I, Matnjani G, Sandrock D, Richter M, Wurm R, Budach V, Feussner A, Gellermann J, Jordan A, Scholz R, Gneveckow U, Maier-Hauff K, Ullrich R, Wust P, Felix R, Waldöfner N, Seebass M, Ochel HJ, Dani A, Varkonyi A, Osvath M, Szasz A, Messer PM, Blumstein NM, Gottfried HW, Schneider E, Reske SN, Röttinger EM, Grosu AL, Franz M, Stärk S, Weber W, Heintz M, Indenkämpen F, Beyer T, Lübcke W, Levegrün S, Hayen J, Czech N, Mbarek B, Köster R, Thurmann H, Todorovic M, Schuchert A, Meinertz T, Münzel T, Grundtke H, Hornig B, Hehr T, Dilcher C, Chan RC, Mintz GS, Kotani JI, Shah VM, Canos DA, Weissman NJ, Waksman R, Wolfram R, Bürger B, Schrappe M, Timmermann B, Lomax A, Goitein G, Schuck A, Mattke A, Int-Veen C, Brecht I, Bernhard S, Treuner J, Koscielniak E, Heinze F, Kuhlen M, von Schorlemer I, Ahrens S, Hunold A, Könemann S, Winkelmann W, Jürgens H, Gerstein J, Polivka B, Sykora KW, Bremer M, Thamm R, Höpfner C, Gumprecht H, Jäger R, Leonardi MA, Frank AM, Trappe AE, Lumenta CB, Östreicher E, Pinsker K, Müller A, Fauser C, Arnold W, Henzel M, Groß MW, Engenhart-Cabillic R, Schüller P, Palkovic S, Schröder J, Wassmann H, Block A, Bauer R, Keffel FW, Theophil B, Wisser L, Rogger M, Niewald M, van Lengen V, Mathias K, Welzel G, Bohrer M, Steinvorth S, Schleußner C, Leppert K, Röhrig B, Strauß B, van Oorschot B, Köhler N, Anselm R, Winzer A, Schneider T, Koch U, Schönekaes K, Mücke R, Büntzel J, Kisters K, Scholz C, Keller M, Winkler C, Prause N, Busch R, Roth S, Haas I, Willers R, Schultze-Mosgau S, Wiltfang J, Kessler P, Neukam FW, Röper B, Nüse N, Auer F, Melzner W, Geiger M, Lotter M, Kuhnt T, Müller AC, Jirsak N, Gernhardt C, Schaller HG, Al-Nawas B, Klein MO, Ludwig C, Körholz J, Grötz KA, Huppers K, Kunkel M, Olschewski T, Bajor K, Lang B, Lang E, Kraus-Tiefenbacher U, Hofheinz R, von Gerstenberg-Helldorf B, Willeke F, Hochhaus A, Roebel M, Oertel S, Riedl S, Buechler M, Foitzik T, Ludwig K, Klar E, Meyer A, Meier Zu Eissen J, Schwab D, Meyer T, Höcht S, Siegmann A, Sieker F, Pigorsch S, Milicic B, Acimovic L, Milisavljevic S, Radosavljevic-Asic G, Presselt N, Baum RP, Treutler D, Bonnet R, Schmücking M, Sammour D, Fink T, Ficker J, Pradier O, Lederer K, Weiss E, Hille A, Welz S, Sepe S, Friedel G, Spengler W, Susanne E, Kölbl O, Hoffmann W, Wörmann B, Günther A, Becker-Schiebe M, Güttler J, Schul C, Nitsche M, Körner MK, Oppenkowski R, Guntrum F, Malaimare L, Raub M, Schöfl C, Averbeck T, Hacker I, Blank H, Böhme C, Imhoff D, Eberlein K, Weidauer S, Böttcher HD, Edler L, Tatagiba M, Molina H, Ostertag C, Milker-Zabel S, Zabel A, Schlegel W, Hartmann A, Wildfang I, Kleinert G, Hamm K, Reuschel W, Wehrmann R, Kneschaurek P, Münter MW, Nikoghosyan A, Didinger B, Nill S, Rhein B, Küstner D, Schalldach U, Eßer D, Göbel H, Wördehoff H, Pachmann S, Hollenhorst H, Dederer K, Evers C, Lamprecht J, Dastbaz A, Schick B, Fleckenstein J, Plinkert PK, Rübe C, Merz T, Sommer B, Mencl A, Ghilescu V, Astner S, Martin A, Momm F, Volegova-Neher NJ, Schulte-Mönting J, Guttenberger R, Buchali A, Blank E, Sidow D, Huhnt W, Gorbatov T, Heinecke A, Beckmann G, Bentia AM, Schmitz H, Spahn U, Heyl V, Prott PJ, Galalae R, Schneider R, Voith C, Scheda A, Hermann B, Bauer L, Melchert F, Kröger N, Grüneisen A, Jänicke F, Zander A, Zuna I, Schlöcker I, Wagner K, John E, Dörk T, Lochhas G, Houf M, Lorenz D, Link KH, Prott FJ, Thoma M, Schauer R, Heinemann V, Romano M, Reiner M, Quanz A, Oppitz U, Bahrehmand R, Tine M, Naszaly A, Patonay P, Mayer Á, Markert K, Mai SK, Lohr F, Dobler B, Pinkawa M, Fischedick K, Treusacher P, Cengiz D, Mager R, Borchers H, Jakse G, Eble MJ, Asadpour B, Krenkel B, Holy R, Kaplan Y, Block T, Czempiel H, Haverkamp U, Prümer B, Christian T, Benkel P, Weber C, Gruber S, Reimann P, Blumberg J, Krause K, Fischedick AR, Kaube K, Steckler K, Henzel B, Licht N, Loch T, Krystek A, Lilienthal A, Alfia H, Claßen J, Spillner P, Knutzen B, Souchon R, Schulz I, Grüschow K, Küchenmeister U, Vogel H, Wolff D, Ramm U, Licner J, Rudolf F, Moog J, Rahl CG, Mose S, Vorwerk H, Weiß E, Engert A, Seufert I, Schwab F, Dahlke J, Zabelina T, Krüger W, Kabisch H, Platz V, Wolf J, Pfistner B, Stieltjes B, Wilhelm T, Schmuecking M, Junker K, Treutier D, Schneider CP, Leonhardi J, Niesen A, Hoeffken K, Schmidt A, Mueller KM, Schmid I, Lehmann K, Blumstein CG, Kreienberg R, Freudenberg L, Kühl H, Stahl M, Elo B, Erichsen P, Stattaus H, Welzel T, Mende U, Heiland S, Salter BJ, Schmid R, Stratakis D, Huber RM, Haferanke J, Zöller N, Henke M, Lorenzen J, Grzyska B, Kuhlmey A, Adam G, Hamelmann V, Bölling T, Job H, Panke JE, Feyer P, Püttmann S, Siekmeyer B, Jung H, Gagel B, Militz U, Piroth M, Schmachtenberg A, Hoelscher T, Verfaillie C, Kaminski B, Lücke E, Mörtel H, Eyrich W, Fritsch M, Georgi JC, Plathow C, Zieher H, Kiessling F, Peschke P, Kauczor HU, Licher J, Schneider O, Henschler R, Seidel C, Kolkmeyer A, Nguyen TP, Janke K, Michaelis M, Bischof M, Stoffregen C, Lipson K, Weber K, Ehemann V, Jürgen D, Achanta P, Thompson K, Martinez JL, Körschgen T, Pakala R, Pinnow E, Hellinga D, O'Tio F, Katzer A, Kaffer A, Kuechler A, Steinkirchner S, Dettmar N, Cordes N, Frick S, Kappler M, Taubert H, Bartel F, Schmidt H, Bache M, Frühauf S, Wenk T, Litzenberger K, Erren M, van Valen F, Liu L, Yang K, Palm J, Püsken M, Behe M, Behr TM, Marini P, Johne A, Claussen U, Liehr T, Steil V, Moustakis C, Griessbach I, Oettel A, Schaal C, Reinhold M, Strasssmann G, Braun I, Vacha P, Richter D, Osterham T, Wolf P, Guenther G, Miemietz M, Lazaridis EA, Forthuber B, Sure M, Klein J, Saleske H, Riedel T, Hirnle P, Horstmann G, Schoepgens H, Van Eck A, Bundschuh O, Van Oosterhut A, Xydis K, Theodorou K, Kappas C, Zurheide J, Fridtjof N, Ganswindt U, Weidner N, Buchgeister M, Weigel B, Müller SB, Glashörster M, Weining C, Hentschel B, Sauer OA, Kleen W, Beck J, Lehmann D, Ley S, Fink C, Puderbach M, Hosch W, Schmähl A, Jung K, Stoßberg A, Rolf E, Damrau M, Oetzel D, Maurer U, Maurer G, Lang K, Zumbe J, Hahm D, Fees H, Robrandt B, Melcher U, Niemeyer M, Mondry A, Kanellopoulos-Niemeyer V, Karle H, Jacob-Heutmann D, Born C, Mohr W, Kutzner J, Thelen M, Schiebe M, Pinkert U, Piasswilm L, Pohl F, Garbe S, Wolf K, Nour Y, Barwig P, Trog D, Schäfer C, Herbst M, Dietl B, Cartes M, Schroeder F, Sigingan-Tek G, Feierabend R, Theden S, Schlieck A, Gotthardt M, Glowalla U, Kremp S, Hamid O, Riefenstahl N, Michaelis B, Schaal G, Liebermeister E, Niewöhner-Desbordes U, Kowalski M, Franz N, Stahl W, Baumbach C, Thale J, Wagner W, Justus B, Huston AL, Seaborn R, Rai P, Rha SW, Sakas G, Wesarg S, Zogal P, Schwald B, Seibert H, Berndt-Skorka R, Seifert G, Schoenekaes K, Bilecen C, Ito W, Matschuck G, and Isik D

Published
2004
Full Text
View/download PDF

29. [Not Available].

Author

Ott OJ, Strnad V, Pötter R, Hammer J, Hildebrandt G, Resch A, Kovács G, Beckmann MW, Sauer R, Niehoff P, Polgar C, Ostertag H, Major T, Eidtmann H, Jonat W, Kimmig B, Roddiger SJ, Kolotas C, Kuner RP, Martin T, Kurek R, Baltas D, Rogge B, Kautschur H, Hoffmann G, Pollow B, Kontova M, Zamboglou N, Ott O, Lotter M, Gallino A, Mahler F, Niewald M, Jafari F, Hennen B, Wisser L, Fleckenstein J, Rübe Ch, Böhm M, Micke O, Wagner W, Schäfer U, Willich N, Greiner RH, Pallas A, Pajic B, Collen T, Meurer N, Töpfer M, Ries G, Leutloff U, Frei S, Warszawski A, Baumann R, Möller T, Niedermeyer J, Karstens JH, Gripp S, Muskalla K, Pulte T, Ohmann C, Röddiger S, Dannenberg T, Tunn UW, Dimopoulos J, Schard G, Kirisits C, Lang S, Goldner G, Wachter S, Wachter-Gerstner N, Helbich T, Weise C, Bendel M, Kocher M, Müller RP, Engelmann U, Aebersold DM, Isaak B, Vetterli D, Kemmerling L, Thalmann G, Behrensmeier F, Mini R, Baier K, Wulf J, Nürnberg N, Egberts J, Galalae R, Maurer U, Maurer G, Lang K, Zumbé J, Block T, Czempiel H, Machtens S, Ponholzer A, Riedl A, Oismüller R, Somay C, Hawliczek R, Maier U, Madersbacher S, Hoinkis C, Winkler C, Lehmann D, Hakenberg O, Herrmann T, Messer PM, Gottfried HW, Schneider E, Röttinger EM, Haverkamp U, Prümer BA, Krause K, Tschuschke C, Blumberg J, Benkel P, Fischedick AR, Geiger MH, Hoffmann TC, Reible M, Meyer-Venter R, Plümpe A, Bund J, Dreikorn K, Staar S, Horn G, Zimmermann JS, Pfeiffer D, Tauber R, Bruns T, Osieka R, Blumstein NM, Schmidt W, Büchler F, Prikler L, Seelentag W, Koch K, Haker H, König F, Oesterwitz H, Schütz R, Stahl H, Ullmann A, Sztankay A, Rachbauer F, Kreczy A, Sununu T, Bach C, Nogler M, Krismer M, Eichberger P, Schiestl B, Lukas P, Wolf A, Hänsgen G, Dunst J, Utzig D, Knocke-Abulesz TH, Baldass M, Kucera H, Weitmann HD, Waldhäusl C, Nechvile E, Knocke TH, Georg D, Krause U, Fröhlich D, Glatzel M, Büntzel J, Schröder D, Küttner K, Pfreundnerx L, Willner J, Bratengeier K, Schwager K, Hoppe F, Schwab F, Sauer O, Flentje M, Tselis N, Schneider O, Stückle CA, Adamietz IA, Weitman HD, Tepel J, Schmid A, Kohr P, Kremer B, Moh'd S, Frey JG, Tschopp JM, Bieri S, Jeszensky D, Liebsch N, Seelentag WW, Karle H, Jacob-Heutmann D, Born C, Mohr W, Kutzner J, Thelen M, Blochberger P, Wächtler M, Kaulich TW, Zurheide J, Haug T, Nüsslin F, Bamberg M, Curschmann J, Kranzbühler H, Greiner R, Cossmann PH, Caversaccio M, Pappas I, and Nolte LP

Published
2004
Full Text
View/download PDF

30. [Use of complementary/alternative therapy methods by patients with breast cancer].

Author

Schönekaes K, Micke O, Mücke R, Büntzel J, Glatzel M, Bruns F, and Kisters K

Subjects
Adult, Aged, Breast Neoplasms pathology, Carcinoma secondary, Complementary Therapies methods, Female, Health Knowledge, Attitudes, Practice, Humans, Middle Aged, Radiotherapy, Adjuvant, Breast Neoplasms therapy, Carcinoma therapy, Complementary Therapies statistics & numerical data, Neoplasm Recurrence, Local therapy
Abstract

Background: Complementary/alternative medicine (CAM) is gaining increasing importance especially in the treatment of patients with breast carcinoma. The purpose of this analysis was to investigate the prevalence of CAM in patients with breast carcinoma, to statistically describe the preparations and therapies used, and to determine the reasons for their use, the source of information and the individual perception., Patients and Methods: The statements of 203 patients with breast carcinoma who underwent radiotherapy were analyzed. The median age was 54 years (range 38-77 years). All patients underwent surgery as first therapy. 36 patients received a second-line radiotherapy because of metastases (27 patients) or local recurrence (9 patients)., Results: 159 patients (78%) stated to carry out an additional treatment. 31 out of the 36 patients with metastases or local recurrence used CAM. Vitamin preparations (67%), mistletoe therapy (59%), and mineral preparations (33%) were used most frequently. 70% of the patients used a combination of two or more preparations/therapies. The most cited reason for using CAM was the aim of increasing quality of life (28%) and improving the immune system (27%). 72% stated an improvement of their individual perception. The main source of information was the general practitioner or the gynecologist., Conclusion: The radiotherapist has to take these complementary/alternative therapies into consideration; their importance should be evaluated in further studies., (Copyright 2003 S. Karger GmbH, Freiburg)

Published
2003
Full Text
View/download PDF

31. [Status of essential trace elements in untreated carcinomas of the head and neck].

Author

Büntzel J, Glatzel M, Micke O, and Fröhlich D

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell radiotherapy, Combined Modality Therapy, Copper blood, Female, Glutathione Peroxidase blood, Humans, Iron blood, Male, Malondialdehyde blood, Middle Aged, Neoplasm Staging, Otorhinolaryngologic Neoplasms drug therapy, Otorhinolaryngologic Neoplasms pathology, Otorhinolaryngologic Neoplasms radiotherapy, Reference Values, Selenium blood, Selenium deficiency, Zinc blood, Carcinoma, Squamous Cell blood, Otorhinolaryngologic Neoplasms blood, Trace Elements blood
Abstract

Background: The changed mineral status is well known in different tumor types. This phenomenon has influenced the redox potential of patients suffering from solid cancers. A prospective trial was conducted to evaluate the specifics for untreated head and neck cancer patients., Material and Methods: We included 100 patients with advanced squamous cell carcinoma of the head and neck region before each kind of treatment. Following serum-concentrations were measured by atom absorption spectrometry: selenium, copper, zinc, and ferrum. Additionally we evaluated the activity of glutathion peroxidase and the concentration of malondialdehyde of the serum., Results: 66 % of all patients have shown a decreased serum-concentration of selenium. These patients were additionally characterized by decreased activities of endogenous glutathionperoxiase. A third of all patients had decreased zinc and iron levels. Copper was found enhanced in 30 %. In trend the malondialdehyde was increasing due to decreasing selenium levels., Conclusions: Head neck cancer patients show the same characteristic trace element status as other solid tumors: decreased selenium, zinc and iron, increased copper. The therapeutic consequences of these observations are still unclear.

Published
2003
Full Text
View/download PDF

32. [Prions as the driving force in transmissible spongiform encephalopathies].

Author

Glatzel M, Gottwein J, and Aguzzi A

Subjects
Animals, Humans, Prion Diseases transmission, Risk Factors, Prion Diseases etiology, Prions physiology, Zoonoses
Abstract

Transmissible spongiform encephalopathies are degenerative disorders affecting the central nervous system (CNS) occurring in a variety of species. The causative agent is thought to be composed of an abnormal form of the host encoded prion protein (PrPC), termed PrPSc. The conformational change of PrPC into PrPSc can occur spontaneously, however, it can also be induced by PrPSc. Prion diseases such as bovine spongiform encephalopathy (BSE), scrapie and variant Creutzfeldt-Jakob-Disease (vCJD) are most likely caused by peripheral uptake of prions. The process by which prions proceed to the CNS following peripheral uptake is referred to as neuroinvasion. Infection with prions is thought to occur in two phases: After ingestion prions first replicate in lymphatic tissue and then gain access to the CNS via peripheral nerves. Studies looking at the biochemical and clinical characteristics of BSE and vCJD demonstrated that BSE is most likely responsible for vCJD in humans.

Published
2002
Full Text
View/download PDF

33. [Transmissible spongiform encephalopathies in humans].

Author

Rogivue C, Gottwein J, Aguzzi A, and Glatzel M

Subjects
Animals, Cattle, Creutzfeldt-Jakob Syndrome epidemiology, Creutzfeldt-Jakob Syndrome therapy, Creutzfeldt-Jakob Syndrome transmission, Encephalopathy, Bovine Spongiform epidemiology, Encephalopathy, Bovine Spongiform therapy, Encephalopathy, Bovine Spongiform transmission, Humans, Prion Diseases epidemiology, Prion Diseases therapy, Switzerland epidemiology, Brain pathology, Prion Diseases transmission, Zoonoses
Abstract

Transmissible spongiform encephalopathies (TSE) are dementing diseases and have been known to affect humans for over 90 years. The most common of these is the sporadic form of Creutzfeldt-Jakob disease (sCJD), followed by its familial (fCJD) and an iatrogenic (iCJD) form. 1996 a variant of CJD (vCJD) has been described in the UK, of which so far 131 cases have been observed worldwide. Specific biochemical and neuropathological signatures allow to distinguish between vCJD and sCJD and lead to the hypothesis that vCJD is due to transmission of BSE prions to humans. Although promising therapeutical approaches are being investigated, human TSE remain untreatable entities. Thus preventive measures are essential. In Switzerland the population has been exposed to BSE prions, too, but no case of vCJD as described in the UK has been observed until now. Since 2001, however, a so far unexplained increase of sCJD cases is being observed.

Published
2002
Full Text
View/download PDF

34. [Eosinophilia and polyneuropathy after percutaneous transluminal coronary angioplasty].

Author

Enzler T, Glatzel M, and Maggiorini M

Subjects
Aged, Angina Pectoris diagnostic imaging, Arteries pathology, Coronary Angiography, Coronary Disease diagnostic imaging, Embolism, Cholesterol pathology, Fatal Outcome, Humans, Male, Myocardial Infarction, Polyneuropathies pathology, Sural Nerve blood supply, Sural Nerve pathology, Angioplasty, Balloon, Coronary adverse effects, Coronary Disease therapy, Eosinophilia etiology, Polyneuropathies etiology
Abstract

History and Clinical Findings: A 76-year-old man was admitted for a coronary angiography because of a postinfarction angina. Clinical examination was normal except a grade 2/6 systolic murmur and a slightly impaired vibration sense., Investigations: A slight anaemia, a slightly impaired renal function, and a slightly elevated cholesterol level could be found. The ECG showed a chronic anterior myocardial infarction. In the coronary angiography a double vessel disease was seen., Treatment and Course: A percutaneous transluminal coronary angioplasty of the left anterior descending artery was performed and four stents were implanted. During the procedure a rush occurred in both legs following an appearance of livedo reticularis. Renal function deteriorated and there was an markedly increased number of eosinophils. With a new neurological check a marked peripheral neuropathy could be found. A biopsy of the sural nerve showed a necrotizing granulomatous inflammation of the nerve and the surrounding small arteries. Several small arteries contained needle shaped crystal clefts in their walls. The appearances were of multiple cholesterol emboli. Besides treatment of pain an immunosuppressive therapy with prednisone (100 mg/d) and cyclophosphamide (50 mg/d) showed no improvement. The patient died 2 months after the diagnosis of cholesterol emboli., Conclusion: Typically, cholesterol embolism occurs in elderly men within the eight weeks after arterial procedure. Diagnosis can be made only by histological examination. Cholesterol emboli syndrome may mimic systemic vasculitis. Therapy trial of cholesterol emboli syndrome usually fails and mortality rate is high.

Published
2000
Full Text
View/download PDF

35. [Radiotherapy of hidradenitis suppurativa--still valid today?].

Author

Fröhlich D, Baaske D, and Glatzel M

Subjects
Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Radiotherapy Dosage, Retrospective Studies, Treatment Outcome, Hidradenitis Suppurativa radiotherapy
Abstract

Purpose: In a retrospective analysis the efficacy of radiotherapy in the treatment of hidradenitis suppurativa was assessed., Patients and Methods: Data from 231 patients undergoing radiotherapy for hidradenitis suppurativa in the last years in 2 hospitals were analyzed. The patients were treated with an orthovoltage therapy unit with 175 kV, 0.5 mm copper-filtering. The single doses reached from 0.5 Gy to 1.5 Gy up to total doses between 3.0 Gy and 8.0 Gy in one series. In chronic recurrent disease 2 or more series with a total dose of more than 10.0 Gy were given., Results: Complete relief of symptoms at the end of radiotherapy was achieved in 89 patients (38%). In 92 patients (40%) there was clear improvement of symptoms. Only 2 patients did not react to radiotherapy. No side effects of radiotherapy occurred., Conclusion: Radiotherapy should be given more consideration as a treatment option for hidradenitis suppurativa.

Published
2000

36. [Prevention of radiation-induced diarrhea by smectite. Results of a double-blind randomized, placebo-controlled multicenter study].

Author

Hombrink J, Fröhlich D, Glatzel M, Krauss A, Thiel HJ, Meier J, Hamann D, Mücke R, Glaser FH, and Köst S

Subjects
Aged, Data Interpretation, Statistical, Diarrhea etiology, Double-Blind Method, Female, Gastrointestinal Agents administration & dosage, Humans, Lymphoma radiotherapy, Male, Middle Aged, Placebos, Prostatic Neoplasms radiotherapy, Radiotherapy Dosage, Rectal Neoplasms radiotherapy, Time Factors, Uterine Cervical Neoplasms radiotherapy, Uterine Neoplasms radiotherapy, Abdomen radiation effects, Diarrhea prevention & control, Gastrointestinal Agents therapeutic use, Pelvis radiation effects, Radiotherapy adverse effects, Silicates
Abstract

Purpose: Diarrhea and abdominal pain are well-known side effects abdominal or pelvic of radiation therapy that may lead to interruption of treatment in serious cases. In recent trials the silicate smectite has proven a promising drug in the prophylaxis of these adverse events. The presented trial aimed at the verification of earlier studies and the evaluation of a dose-effect relationship., Patients and Methods: Between April 1994 and May 1995, a total of 176 patients obtaining radiotherapy of the pelvis or the abdomen were evaluated in a double-blind, randomized placebo-controlled investigation regarding the prophylactic effect of smectite (= Colina) against radiotherapy-induced diarrhea. During the whole period of radiotherapy 85 patients obtained 2 x 6 g smectite daily and 91 patients received 2 x 6 g placebo. The primary end point of the analysis was the time to the first appearance of diarrhea (> or = 3 pappy stools)., Results: All 176 patients were evaluated according to an intent-to-treat analysis. There was no significant difference between the prophylactic effects of smectite and placebo. For an explorative post-hoc analysis the total study group was split up into 2 subgroups, one with an irradiated small bowel volume < or = 837.5 ml, the other with a small bowel volume > 837.5 ml (median); the analysis indicated that the first subgroup showed a benefit for the smectite-treated patients in contrast to the placebo treatment (32 vs. 18 calendar days to the first appearance of diarrhea). This benefit was statistically not significant., Conclusion: Prophylactic application of smectite during irradiation of the pelvis and the abdomen can delay the development of radiotherapy-induced diarrhea, a statistical significance could not be verified neither in the total study group nor in the post-hoc subgroup analysis.

Published
2000
Full Text
View/download PDF

37. [Cytoprotection with amifostine in the framework of radiochemotherapy in previously irradiated head and neck carcinoma].

Author

Büntzel J, Glatzel M, Schuth J, Weinaug R, Küttner K, and Fröhlich D

Subjects
Adult, Aged, Amifostine administration & dosage, Anemia etiology, Anemia prevention & control, Antineoplastic Agents administration & dosage, Antineoplastic Agents therapeutic use, Brachytherapy, Carboplatin administration & dosage, Carboplatin therapeutic use, Combined Modality Therapy, Deglutition Disorders etiology, Deglutition Disorders prevention & control, Female, Head and Neck Neoplasms surgery, Humans, Leukopenia etiology, Leukopenia prevention & control, Male, Middle Aged, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local radiotherapy, Neoplasms, Second Primary drug therapy, Neoplasms, Second Primary radiotherapy, Postoperative Care, Radiation-Protective Agents administration & dosage, Radiotherapy adverse effects, Radiotherapy Dosage, Stomatitis etiology, Stomatitis prevention & control, Thrombocytopenia etiology, Thrombocytopenia prevention & control, Time Factors, Xerostomia etiology, Xerostomia prevention & control, Amifostine pharmacology, Cytoprotection, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms radiotherapy, Neoplasm Recurrence, Local therapy, Neoplasms, Second Primary therapy, Radiation-Protective Agents pharmacology
Abstract

Purpose: The radiotherapeutic possibilities are limited for patients with a recurrent or second head and neck cancer if the patient was already irradiated in the first therapy. In the presented study we investigated the changes of this situation due to the usage of amifostine in the case of re-irradiation (simultaneous radio-chemotherapy)., Patients and Methods: Between 1995 and 1997 we treated 14 patients with a recurrent or second malignancy of the head and neck region by a simultaneous radio-chemotherapy (20 x 1.5 Gy, Carboplatin 70 mg/m2 BSA on days 1 to 5 and 16 to 20, 500 mg amifostine prior to every carboplatin infusion). Six out of 14 patients got an additional brachytherapy (10 to 15 Gy) to increase the local dose because of a residual tumor. In 4 cases the treatment was an adjunctive one, following the surgical tumor debulking., Results: We have seen 3 complete remissions (21.4%), and 8 partial remissions (57.1%). The median time of observation is 13 months now. Three out of 14 patients died, 2 because of the tumor. Hematological toxicities: side effects Grade 2 WHO were seen only in 1 patient. Acute non-hematological toxicities: mucositis Grade 0/1 in 7 patients, mucositis Grade 2 in 7 patients, dysphagia Grade 0/1 in 9 patients, dysphagia Grade 2 in 5 patients, xerostomia Grade 1 in 9 patients, xerostomia Grade 2 in 3 patients. We registrated only 1 serious late toxicity due to radio-chemotherapy: 4 months after brachytherapy a patient (with laryngectomy) developed a submental fistula., Conclusion: These first results suggest that the usage of amifostine offers new potential ways for re-irradiation of patients with recurrent or second malignancies in the head neck region.

Published
1999

38. [Therapy trends in the prevention of radiation-induced diarrhea after pelvic and abdominal irradiation. Results of a tricenter study].

Author

Hombrink J, Voss AC, Fröhlich D, Glatzel M, Krauss A, and Glaser FH

Subjects
Adult, Aged, Aged, 80 and over, Brachytherapy adverse effects, Diarrhea drug therapy, Diarrhea prevention & control, Female, Genital Neoplasms, Female radiotherapy, Humans, Lymphoma, Non-Hodgkin radiotherapy, Male, Middle Aged, Radiotherapy Dosage, Rectal Neoplasms radiotherapy, Time Factors, Urogenital Neoplasms radiotherapy, Abdomen radiation effects, Diarrhea etiology, Gastrointestinal Agents therapeutic use, Pelvis radiation effects, Radiotherapy adverse effects, Silicates
Abstract

Purpose: Radiotherapy induced diarrhea and convulsive pain are severe side-effects of irradiation of the pelvis and the abdomen leading often to an interruption of the treatment. Up to now these side-effects were only treated symptomatically, prophylactic therapies are not known., Patients and Methods: During the years 1992 and 1993 174 patients who obtained radiotherapy in the pelvis or the abdomen because of different malignancies were observed referring to the diarrhea-prophylactic effect of Smectite (= Skilpin). 80 patients received Smectite at the beginning of radiotherapy, 94 patients of the control group were treated with motility modifying drugs when diarrhea appeared. The following parameters were compared: Frequency, consistence and incontinence of stool, tenesmus and the onset of diarrhea., Results: 67.0% (n = 63) of the patients in the control group developed diarrhea, whereas in the pretreated Smectite-group only 37.5% of the cases (n = 30) developed diarrhea. The first appearance of diarrhea was at day 17 in the pretreated group and averagely at day 11 in the control group. 44% of the patients in the control group suffered from tenesmus versus 25% in the Smectite-group., Conclusion: In comparison to the symptomatic treatment of radiation enteritis the prophylactic application of Smectite is able to reduce the diarrhea from the beginning of radiotherapy or at least to reduce the pathological frequency of stool and therefore to increase the quality of life.

Published
1995

39. [Lumbar ultrasound tomography--normal ultrasound anatomy, intervertebral disk displacement, lumbar stenosis].

Author

Hagen A, Deutschmann C, Tertsch D, Glatzel M, and Rieger A

Subjects
Adipose Tissue pathology, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Intervertebral Disc pathology, Male, Middle Aged, Intervertebral Disc Displacement diagnosis, Lumbar Vertebrae pathology, Spinal Stenosis diagnosis, Ultrasonography methods
Abstract

595 lumbar segments of 300 patients mostly investigated for lumbar radicular syndromes were demonstrated by transabdominal ultrasonic tomography. Statistical analysis of the findings allowed to identify criteria for normal anatomy of lumbar discs and spinal canal as well as for disc herniation and lumbar stenosis.

Published
1989
Full Text
View/download PDF

40. [Comparative ultrasound and computerized tomography studies of lumbar intervertebral disks and the lumbar canal].

Author

Hagen A, Glatzel M, and Baars HG

Subjects
Humans, Reference Values, Spinal Neoplasms diagnosis, Spinal Neoplasms secondary, Image Interpretation, Computer-Assisted, Intervertebral Disc pathology, Lumbar Vertebrae pathology, Microcomputers, Tomography, X-Ray Computed, Ultrasonography instrumentation
Abstract

Sonography and computerised tomography were carried out on 61 lumbar segments (L5/S1, L4/5, L3/4) of 30 patients not having vertebrogenous symptoms. Transabdominal lumbar sonography with a 3.5 MHz sector probe proved to be a valuable imaging method, allowing to demonstrate the shape and dorsal outline of the lumbar discs. Bowl-shaped, right-angled and funnel-shaped configurations of the dorsal spinal canal are typical findings. The interpretation of the ultrasonic tomograms and the identification of normal anatomy are improved through comparative imaging by computerised tomography.

Published
1989
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results