1. [Comparative investigation of the efficacy of two nucleocapsid analogs in FIV infected cats]
- Author
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Kuffer M, Balzarini J, Rolinski B, Goebel F, Erfle V, Goldberg M, and Katrin Hartmann
- Subjects
Placebos ,Organophosphorus Compounds ,Treatment Outcome ,Double-Blind Method ,Adenine ,Feline Acquired Immunodeficiency Syndrome ,Cats ,Organophosphonates ,Animals ,Immunodeficiency Virus, Feline ,Antiviral Agents - Abstract
Antiviral activity of the acyclic nucleoside phosphonates 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) against feline immunodeficiency virus (FIV) was investigated in field cats. The study was designed as a placebo-controlled double-blind study enrolling 27 FIV infected cats. Nine cats received PMEA at a dosage of 10 mg/kg body weight, nine cats received FPMPA at a dosage of 25 mg/kg body weight. A variety of parameters were established to evaluate the therapeutic efficacy of the compounds. The improvement was monitored by different aspects: clinical status, index of Karnofsky modified for the cat, laboratory parameters, immunological parameters, surrogate markers, and a virological parameter. Concerning the clinical and immunological parameters cats of both treatment groups disclosed a relevant improvement. Efficacy of antiviral treatment was a little bit higher in the cats treated with PMEA than in the animals injected with FPMPA. However, side effects were also more prominent in the PMEA treated group.
- Published
- 1998