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8 results on '"Holland J"'

2. Bücherschau

Author

Grassmann, Peter, Grigull, U., Baehr, H. D., Franz, W., Peukert, H., Hahnemann, H. W., Kollmann, K., Quade, W., Wittmeyer, Helmut, Scholz, N., Gunz, W., Deunert, Kurl, and Holland, J.

Published
1959
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7. [Phase-II-study with cis-diamminedichloroplatinum (II) in the treatment of advanced malignant lymphomas].

Author

Cavalli F, Jungi WF, Sonntag RW, Nissen NI, and Holland JH

Subjects
Cisplatin adverse effects, Drug Evaluation, Humans, Vomiting chemically induced, Cisplatin therapeutic use, Lymphoma drug therapy
Abstract

29 patients with advanced malignant lymphoma were included in a phase-II trial conducted by Cancer and Acute Leukemia Group B. The patients received cis-diamminedichloroplatinum (DDP) in a dose of 70 mg/m2 every three weeks. In this still ongoing study, 23 patients are already evaluable. Out of 23 cases partial remission was observed in 6. The main toxicity was profuse vomiting. Myelosuppression and nephrotoxicity were both manageable. Based on these preliminary data, the incorporation of DDP in combination chemotherapy for malignant lymphoma appears to be warranted.

Published
1980

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