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Your search keyword '"Hydroxybenzoates chemical synthesis"' showing total 4 results
Start Over Descriptor "Hydroxybenzoates chemical synthesis" Language german
4 results on '"Hydroxybenzoates chemical synthesis"'

1. [Antiestrogenic N-(4-hydroxyphenyl)-n-(1,1,1,-trifluoro-2-propyl)-4- hydroxybenzamides: influence of hydrophobic groups substituted in the ortho-position of the benzamide-fragment on activity].

Author

Hartmann RW, vom Orde HD, and Schönenberger H

Subjects
Animals, Chemical Phenomena, Chemistry, Female, Hydroxybenzoates metabolism, Hydroxybenzoates pharmacology, Mice, Mice, Inbred Strains, Receptors, Estrogen metabolism, Uterus drug effects, Estrogen Antagonists chemical synthesis, Hydroxybenzoates chemical synthesis
Abstract

Experiments are reported here to develop compounds with antiestrogenic and mammary tumor inhibiting properties. Analogues with hydrophobic groups in 2- or 2,6-position of the benzamide-fragment of N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)- 4-hydroxybenzamides were investigated. Compounds 2 and 3 proved to be "true" antiestrogenes among 2-7 (2: 2-CH3, 3: 2-F, 4: 2-Cl, 5: 2-Br, 6: 2,6-Cl2, 7: 2-CF3). Compound 4 showed the highest activity on the MXT-MC, ER+.

Published
1990
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4. [N-(4-hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxyben zamide: synthesis and pharmacologic evaluation of a new antiestrogen].

Author

Hartmann RW, vom Orde HD, Heindl A, and Schönenberger H

Subjects
Animals, Estrogen Antagonists pharmacology, Female, Hydroxybenzoates pharmacology, Mammary Neoplasms, Experimental drug therapy, Mice, Mice, Inbred Strains, Neoplasms, Hormone-Dependent drug therapy, Rats, Uterus drug effects, Estrogen Antagonists chemical synthesis, Hydroxybenzoates chemical synthesis
Published
1988
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