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Returning to work often fails due to conflicting expectations and goals of the stakeholders involved. Due to their medical expertise and workplace-related knowledge, occupational physicians could effectively promote mutual understanding and cooperation between the stakeholders. The study aimed to develop a manual and training session for its application that will support occupational physicians to assume a mediating role in the integration of employees with a mental illness.Based on a literature review and extensive qualitative preliminary work on the expectations of the stakeholders, the manual and training materials were developed, discussed and revised in several consecutive steps based on a participatory approach with occupational physicians and other experts. Finally, occupational physicians were trained to use the manual during their specialization training in order to subsequently test its practicability in everyday work.The manual presents information on the potentially different expectations of the actors for the return process and offers comprehensive advice for the mediating work of the occupational physicians. After a manualized training of approximately 2h, 9 out of 37 participants used the manual for return interviews within 4 months and 6 out of 9 rated it as helpful.The first positive experiences of using the material developed with the target group justify a larger interventional study to investigate the presumed beneficial effects on the success of reintegration.