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Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Synthesis is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Zusammenfassung: Das obstruktive Schlafapnoesyndrom (OSAS) betrifft 13–33% der Männer und 6–9% der Frauen weltweit und stellt erhebliche Behandlungsherausforderungen dar, einschließlich der schlechten Einhaltung des kontinuierlichen positiven Atemwegsdrucks (CPAP) und der verbleibenden übermäßigen Schläfrigkeit (RES). Diese Übersichtsarbeit zielt darauf ab, das aufkommende Interesse an pharmakologischen Behandlungen für das OSAS zu erläutern, wobei der Schwerpunkt auf den jüngsten Fortschritten in diesem Bereich liegt. Es wurde eine gründliche Analyse umfangreicher klinischer Studien mit verschiedenen Medikamenten, einschließlich selektiver Dopamin-Wiederaufnahmehemmer, selektiver Noradrenalinhemmer und kombinierter Antimuskarinika und Orexin-Agonisten, durchgeführt. Diese Studien konzentrierten sich auf die Verbesserung der Atemmetriken und der Schlafqualität bei Personen, die vom OSAS betroffen sind. Die untersuchten pharmakologischen Wirkstoffe zeigten das Potenzial zur Verbesserung der primären Ergebnisse, insbesondere des Apnoe-Hypopnoe-Index (AHI) sowie der Epworth-Schläfrigkeitsskala (ESS). Diese Verbesserungen deuten auf eine verbesserte Schlafqualität und Symptombehandlung bei OSAS-Patienten hin. Mit einem tieferen Verständnis des OSAS entwickeln sich pharmakologische Interventionen in eine vielversprechende Richtung für ein effektives Management. Diese Übersichtsarbeit bietet einen umfassenden Überblick über den aktuellen Stand der Arzneimittelforschung zum OSAS und hebt das Potenzial dieser Behandlungen bei der Bewältigung der komplexen Herausforderungen der Erkrankung hervor. [ABSTRACT FROM AUTHOR]

Cage-like polycycles represent a class of structurally unique and biologically promising molecules, however, efficient approaches for their synthesis are rare. Herein, we disclose RhI-catalyzed cycloisomerization reactions of 1,7-enynes containing a chelating group at the alkyne terminus, which afford unprecedented cage-like tricyclo[3.2.2.06,8 ]nonenes via a 7- endo -dig cyclization. This work not only provides a straightforward approach to these novel cage-like tricycles, but also unveils the under-explored π-acidic reactivity of the RhI catalyst aided by secondary chelation. [ABSTRACT FROM AUTHOR]

Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Technisches Messen is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper commemorates the 1050th anniversary of Abu Rayhan Al-Biruni and delves into his unparalleled contributions to the geosciences and cartography within the context of the Islamic Golden Age. Al-Biruni's work, characterized by its interdisciplinary approach and meticulous methodology, has not only advanced the field of geography but also connected diverse cultural perspectives. By examining Al-Biruni's groundbreaking contributions, this study highlights his innovative methods for measuring the Earth's radius, his unique cartographic representations, and his synthesis of knowledge from various civilizations. Focusing on Al-Biruni's contributions from both a geographical and educational perspective, we illuminate his timeless impact on the discipline and provide insights that are of central importance to contemporary geography researchers and educators. This study underscores the importance of integrating Al-Biruni's interdisciplinary methods, critical thinking, and crosscultural analyses into modern geographical education, thereby enriching the academic exploration of geography and fostering a deeper appreciation for the interconnectedness of global cultures and scientific advancements. [ABSTRACT FROM AUTHOR]