21 results on '"Loeffler M"'
Search Results
2. Studienprotokoll der VISEP-Studie: Entgegnung der SepNet-Studiengruppe
- Author
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Reinhart, K., Brunkhorst, F.M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., Olthoff, D., Jaschinski, U., John, S., Rossaint, R., Welte, T., Schaefer, M., Kern, P., Kuhnt, E., Kiehntopf, M., Deufel, T., Hartog, C., Gerlach, H., Stüber, F., Volk, H.-D., Quintel, M., Loeffler, M., and für die Deutsche Studiengruppe Kompetenznetzwerk Sepsis (SepNet)
- Published
- 2008
- Full Text
- View/download PDF
3. Nächtliche Verkehrslärmbelästigung in Deutschland: individuelle und regionale Unterschiede in der NAKO Gesundheitsstudie [Nighttime transportation noise annoyance in Germany: personal and regional differences in the German National Cohort Study
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Wolf, K., Kraus, U., Dzolan, M., Bolte, G., Lakes, T., Schikowski, T., Greiser, K., Kuß, O., Ahrens, W., Bamberg, F., Becher, H., Berger, K., Brenner, H., Castell, S., Damms-Machado, A., Fischer, B., Franzke, C., Gastell, S., Günther, K., Holleczek, B., Jaeschke, L., Kaaks, R., Keil, T., Kemmling, Y., Krist, L., Legath, N., Leitzmann, M., Lieb, W., Loeffler, M., Meinke-Franze, C., Michels, K.B., Mikolajczyk, R., Moebus, S., Mueller, U., Obi, N., Pischon, T., Rathmann, W., Schipf, S., Schmidt, B., Schulze, M., Thiele, I., Thierry, S., Waniek, S., Wigmann, C., Wirkner, K., Zschocke, J., Peters, A., and Schneider, A.
- Subjects
Cardiovascular and Metabolic Diseases ,human activities - Abstract
BACKGROUND: Noise annoyance is associated with adverse health-related conditions and reduced wellbeing. Thereby, subjective noise annoyance depends on the objective noise exposure and is modified by personal and regional factors. OBJECTIVE: How many participants of the German National Cohort Study (GNC; NAKO Gesundheitsstudie) were annoyed by transportation noise during nighttime and what factors were associated with noise annoyance? MATERIALS AND METHODS: This cross-sectional analysis included 86,080 participants from 18 study centers, examined from 2014 to 2017. We used multinomial logistic regression to investigate associations of personal and regional factors to noise annoyance (slightly/moderately or strongly/extremely annoyed vs. not annoyed) mutually adjusting for all factors in the model. RESULTS: Two thirds of participants were not annoyed by transportation noise during nighttime and one in ten reported strong/extreme annoyance with highest percentages for the study centers Berlin-Mitte and Leipzig. The strongest associations were seen for factors related to the individual housing situation like the bedroom being positioned towards a major road (OR of being slightly/moderately annoyed: 4.26 [95% CI: 4.01;4.52]; OR of being strongly/extremely annoyed: 13.36 [95% CI: 12.47;14.32]) compared to a garden/inner courtyard. Participants aged 40-60 years and those in low- and medium-income groups reported greater noise annoyance compared to younger or older ones and those in the high-income group. CONCLUSION: In this study from Germany, transportation noise annoyance during nighttime varied by personal and regional factors.
- Published
- 2020
4. Mathematische Modelle in der Hämatologie
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Wichmann, H. E., Loeffler, M., Herkenrath, P., Gerhardts, M. D., Wesselborg, C., and Wulff, H.
- Published
- 1983
- Full Text
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5. [Study protocol of the VISEP study. Response of the SepNet study group]
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Reinhart, K, Brunkhorst, F M, Engel, C, Bloos, F, Meier-Hellmann, A, Ragaller, M, Weiler, N, Moerer, O, Gruendling, M, Oppert, M, Grond, S, Olthoff, D, Jaschinski, U, John, S, Rossaint, R, Welte, T, Schaefer, M, Kern, P, Kuhnt, E, Kiehntopf, M, Deufel, T, Hartog, C, Gerlach, H, Stüber, F, Volk, H-D, Quintel, M, and Loeffler, M
- Abstract
In the commentary by Zander et al. the authors appear concerned about the methods and results of our, at that time, unpublished sepsis trial evaluating hydroxyethyl starch (HES) and insulin therapy. Unfortunately, the authors' concerns are based on false assumptions about the design, conduct and modes of action of the compounds under investigation. For instance, in our study the HES solution was not used for maintenance of daily fluid requirements, so that the assumption of the authors that this colloid was used "exclusively" is wrong. Moreover, the manufacturer of Hemohes, the HES product we used, gives no cut-off value for creatinine, thus the assumption that this cut-off value was "doubled" in our study is also incorrect. Other claims by the authors such as that lactated solutions cause elevated lactate levels, iatrogenic hyperglycemia and increase O(2) consumption are unfounded. There is no randomized controlled trial supporting such a claim - this claim is neither consistent with our study data nor with any credible published sepsis guidelines or with routine practice worldwide. We fully support open scientific debate. Our study methods and results have now been published after a strict peer-reviewing process and this data is now open to critical and constructive reviewing. However, in our opinion this premature action based on wrong assumptions and containing comments by representatives of pharmaceutical companies does not contribute to a serious, unbiased scientific discourse.
- Published
- 2008
6. MRI-Phantom zur Optimierung von Meß-Sequenzen.
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Bende, T. (Berlin), Loeffler, M., and Seiler, T.
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- 1986
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7. Absorber material for gas cooled high temperature reactors: irradiation behavior of coated LB particles.
- Author
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Wagner- Loeffler, M
- Published
- 1972
8. [Health Literacy, Contact Points, Unmet Subjective Needs and Treatment Satisfaction of those Affected by Long Covid with Long-Lasting Neuropsychiatric Symptoms].
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Jung F, Zülke A, Wirkner K, Reusche M, Engel C, Sander C, Witte V, Zeynalova S, Loeffler M, Villringer A, Saur D, Schomerus G, Luppa M, and Riedel-Heller SG
- Abstract
Objective: The bejective was to determine health literacy (HL) and care aspects of those affected by Long-COVID., Method: 407 patients with Long-COVID and long-term neuropsychiatric symptoms were interviewed in the LIFE study center. In addition to descriptive analyses, regression models were calculated to examine the relationships between health literacy (HLS-EU-Q16) and various aspects of care (RehaQ-N1)., Results: The results show that 35.8% had problematic and 17.9% had inadequate HL. The majority of subjective needs were unmet and 47.7% of those affected were dissatisfied with the therapy they received., Discussion: Among those affected by Long-COVID, subjective HL is rather reduced. The healthcare system appears to be unprepared for these patients, which is reflected in unmet needs and low treatment satisfaction. This was even more pronounced among those exhibiting lower HL., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (Thieme. All rights reserved.)
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- 2024
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9. [INTERPOLAR-prospective, interventional studies as part of the Medical Informatics Initiative to improve medication therapy safety in healthcare].
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Loeffler M, Maas R, Neumann D, and Scherag A
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- Humans, Drug-Related Side Effects and Adverse Reactions prevention & control, Electronic Health Records, Germany, Medical Informatics, Patient Safety, Prospective Studies, Quality Improvement, Medication Errors prevention & control
- Abstract
Medication analyses by ward pharmacists are an important measure of drug therapy safety (DTS). Medication-related problems (MRPs) are identified and resolved with the attending clinicians. However, staff resources for extended medication analyses and complete documentation are often limited. Until now, data required for the identification of risk patients and for an extended medication analysis often had to be collected from various parts of the institution's internal electronic medical record (EMR). This error-prone and time-consuming process is to be improved in the INTERPOLAR (INTERventional POLypharmacy-Drug interActions-Risks) project using an IT tool provided by the data integration centers (DIC).INTERPOLAR is a use case of the Medical Informatics Initiative (MII) that focuses on the topic of DTS. The planning phase took place in 2023, with routine implementation planned from 2024. DTS-relevant data from the EMR is to be presented and the documentation of MRPs in routine care is to be facilitated. The prospective multicenter, cluster-randomized INTERPOLAR‑1 study serves to evaluate the benefits of IT support in routine care. The aim is to show that more MRPs can be detected and resolved with the help of IT support. For this purpose, six normal wards will be selected at each of eight university hospitals, so that 48 clusters (with a total of at least 70,000 cases) are available for randomization., (© 2024. The Author(s).)
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- 2024
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10. [The Medical Informatics Initiative at a glance-establishing a health research data infrastructure in Germany].
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Semler SC, Boeker M, Eils R, Krefting D, Loeffler M, Bussmann J, Wissing F, and Prokosch HU
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- Humans, Germany, Health Services Research organization & administration, Models, Organizational, Biomedical Research organization & administration, Medical Informatics
- Abstract
The Medical Informatics Initiative (MII) funded by the Federal Ministry of Education and Research (BMBF) 2016-2027 is successfully laying the foundations for data-based medicine in Germany. As part of this funding, 51 new professorships, 21 junior research groups, and various new degree programs have been established to strengthen teaching, training, and continuing education in the field of medical informatics and to improve expertise in medical data sciences. A joint decentralized federated research data infrastructure encompassing the entire university medical center and its partners was created in the form of data integration centers (DIC) at all locations and the German Portal for Medical Research Data (FDPG) as a central access point. A modular core dataset (KDS) was defined and implemented for the secondary use of patient treatment data with consistent use of international standards (e.g., FHIR, SNOMED CT, and LOINC). An officially approved nationwide broad consent was introduced as the legal basis. The first data exports and data use projects have been carried out, embedded in an overarching usage policy and standardized contractual regulations. The further development of the MII health research data infrastructures within the cooperative framework of the Network of University Medicine (NUM) offers an excellent starting point for a German contribution to the upcoming European Health Data Space (EHDS), which opens opportunities for Germany as a medical research location., (© 2024. The Author(s).)
- Published
- 2024
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11. [HerediCaRe: Documentation and IT Solution of a Specialized Registry for Hereditary Breast and Ovarian Cancer].
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Engel C, Wieland K, Zachariae S, Bucksch K, Enders U, Schoenwiese U, Yahiaoui-Doktor M, Keupp K, Waha A, Hahnen E, Remy R, Ernst C, Loeffler M, and Schmutzler RK
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- Female, Germany, Humans, Registries, Software, Documentation, Ovarian Neoplasms genetics
- Abstract
The national registry "HerediCaRe" for the evaluation and improvement of risk-adjusted prevention in hereditary breast and ovarian cancer is one of six "model registries in health services research" funded by the BMBF. In this paper, we describe and discuss the documentation and IT solution chosen for standardized data collection based on the specific functional requirements previously defined. The documentation is divided into different modules to be used individually for each patient, which are based on a previously defined catalog of documentation items. Due to special functional requirements, a specific data entry application based on ORACLE and ORACLE Forms was developed and implemented. The specific requirements included the integration of graphical pedigree representations, the structured upload of pedigree data and molecular genetic information, the automated transfer of old data from the previous system, as well as the free programmability of complex database queries for central data quality control. A database for patient-independent management of genetic risk variants was seamlessly integrated into the application and linked to the patient-related data. The advantages and disadvantages of the chosen IT solution are critically discussed. Overall, we come to the conclusion that, in view of the complex documentation and the special functional requirements, there are no alternative ready-made software products to the in-house development we have chosen., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)
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- 2021
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12. [Self-reported infections in the German National Cohort (GNC) in the context of the current research landscape].
- Author
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Hassenstein MJ, Aarabi G, Ahnert P, Becher H, Franzke CW, Fricke J, Krause G, Glöckner S, Gottschick C, Karch A, Kemmling Y, Kerrinnes T, Lange B, Mikolajczyk R, Nieters A, Ott JJ, Ahrens W, Berger K, Meinke-Franze C, Gastell S, Günther K, Greiser KH, Holleczek B, Horn J, Jaeschke L, Jagodzinski A, Jansen L, Jochem C, Jöckel KH, Kaaks R, Krist L, Kuß O, Langer S, Legath N, Leitzmann M, Lieb W, Loeffler M, Mangold N, Michels KB, Meisinger C, Obi N, Pischon T, Schikowski T, Schipf S, Schulze MB, Stang A, Waniek S, Wirkner K, Willich SN, and Castell S
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- Cohort Studies, Cross-Sectional Studies, Germany epidemiology, Humans, Self Report, Surveys and Questionnaires, Communicable Diseases epidemiology
- Abstract
Background: Infectious diseases continue to play an important role for disease perception, health-economic considerations and public health in Germany. In recent years, infectious diseases have been linked to the development of non-communicable diseases. Analyses of the German National Cohort (GNC) may provide deeper insights into this issue and pave the way for new targeted approaches in disease prevention., Objectives: The aim was to describe the tools used to assess infectious diseases and to present initial data on infectious disease frequencies, as well as to relate the GNC assessment tools to data collection methods in other studies in Germany., Methods: As part of the baseline examination, questions regarding infectious diseases were administered using both an interview and a self-administered touchscreen questionnaire. Data from the initial 101,787 GNC participants were analysed., Results: In the interview, 0.2% (HIV/AIDS) to 8.6% (shingles) of respondents reported ever having a medical diagnosis of shingles, postherpetic neuralgia (in cases where shingles was reported), hepatitis B/C, HIV/AIDS, tuberculosis or sepsis if treated in hospital. In the questionnaire, 12% (cystitis) to 81% (upper respiratory tract infections) of respondents reported having experienced at least one occurrence of upper or lower respiratory tract infections, gastrointestinal infections, cystitis or fever within the past 12 months., Outlook: The cross-sectional analyses of data and tools presented here - for example on determinants of susceptibility to self-reported infections - can be anticipated from the year 2021 onward. Beyond that, more extensive research into infectious disease epidemiology will follow, particularly once analyses of GNC biological materials have been performed.
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- 2020
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13. [Design and quality control of the oral health status examination in the German National Cohort (GNC)].
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Holtfreter B, Samietz S, Hertrampf K, Aarabi G, Hagenfeld D, Kim TS, Kocher T, Koos B, Schmitter M, Ahrens W, Alwers E, Becher H, Berger K, Brenner H, Damms-Machado A, Ebert N, Fischer B, Franzke CW, Frölich S, Greiser H, Gies A, Günther K, Hassan L, Hoffmann W, Jaeschke L, Keil T, Kemmling Y, Krause G, Krist L, Legath N, Lieb W, Leitzmann M, Linseisen J, Loeffler M, Meinke-Franze C, Michels KB, Mikolajczyk R, Obi N, Peters A, Pischon T, Schipf S, Schmidt B, Völzke H, Waniek S, Wigmann C, Wirkner K, Schmidt CO, Kühnisch J, and Rupf S
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- Cohort Studies, Germany, Humans, Quality Assurance, Health Care, Quality Control, Data Collection standards, Dental Caries epidemiology, Mouth Diseases, Oral Health
- Abstract
Background: Caries and periodontitis are highly prevalent worldwide. Because detailed data on these oral diseases were collected within the framework of the German National Cohort (GNC), associations between oral and systemic diseases and conditions can be investigated., Objectives: The study protocol for the oral examination was designed to ensure a comprehensive collection of dental findings by trained non-dental staff within a limited examination time. At the mid-term of the GNC baseline examination, a first quality evaluation was performed to check the plausibility of results and to propose measures to improve the data quality., Materials and Methods: A dental interview, saliva sampling and oral diagnostics were conducted. As part of the level‑1 examination, the number of teeth and prostheses were recorded. As part of the level‑2 examination, detailed periodontal, cariological and functional aspects were examined. All examinations were conducted by trained non-dental personnel. Parameters were checked for plausibility and variable distributions were descriptively analysed., Results: Analyses included data of 57,967 interview participants, 56,913 level‑1 participants and 6295 level‑2 participants. Percentages of missing values for individual clinical parameters assessed in level 1 and level 2 ranged between 0.02 and 3.9%. Results showed a plausible distribution of the data; rarely, implausible values were observed, e.g. for measurements of horizontal and vertical overbite (overjet and overbite). Intra-class correlation coefficients indicated differences in individual parameters between regional clusters, study centres and across different examiners., Conclusions: The results confirm the feasibility of the study protocol by non-dental personnel and its successful integration into the GNC's overall assessment program. However, rigorous dental support of the study centres is required for quality management.
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- 2020
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14. [Gender-Specific Differences in the Utilization of Health Care Services in an Urban Population Sample].
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Keil J, Brendler V, Sachse C, Zülke A, Zeynalova S, Engel C, Loeffler M, Riedel-Heller SG, König HH, and Stengler K
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- Adult, Female, General Practitioners, Germany, Humans, Male, Sex Factors, Urban Population statistics & numerical data, Attitude to Health, Health Services statistics & numerical data
- Abstract
Aim: This study explores gender-specific differences in the utilization of health care services in an urban population sample., Method: As part of the LIFE-ADULT-Study, 2244 individuals (19-79 years) filled out a questionnaire about their use of health care services during the past year. Information regarding the frequency of general and specialized practitioners consultation, medical advice from general practitioners and utilization of preventive and health promoting programs were analyzed., Results: Women visited general practitioners or specialists and utilized prevention and health-promotion programs more often than men. No gender differences were found regarding the frequency of receiving medical advice from general practitioners., Conclusions: The results mainly replicate prior findings showing that women utilize health care services more frequently than men. However, these gender differences vary as a function of the indicator employed and should therefore be discussed differentially., Competing Interests: Die Autoren geben an, dass kein Interessenkonflikt besteht., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2020
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15. [Nighttime transportation noise annoyance in Germany: personal and regional differences in the German National Cohort Study].
- Author
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Wolf K, Kraus U, Dzolan M, Bolte G, Lakes T, Schikowski T, Greiser KH, Kuß O, Ahrens W, Bamberg F, Becher H, Berger K, Brenner H, Castell S, Damms-Machado A, Fischer B, Franzke CW, Gastell S, Günther K, Holleczek B, Jaeschke L, Kaaks R, Keil T, Kemmling Y, Krist L, Legath N, Leitzmann M, Lieb W, Loeffler M, Meinke-Franze C, Michels KB, Mikolajczyk R, Moebus S, Mueller U, Obi N, Pischon T, Rathmann W, Schipf S, Schmidt B, Schulze M, Thiele I, Thierry S, Waniek S, Wigmann C, Wirkner K, Zschocke J, Peters A, and Schneider A
- Subjects
- Berlin, Cohort Studies, Cross-Sectional Studies, Germany, Surveys and Questionnaires, Environmental Exposure, Noise, Transportation
- Abstract
Background: Noise annoyance is associated with adverse health-related conditions and reduced wellbeing. Thereby, subjective noise annoyance depends on the objective noise exposure and is modified by personal and regional factors., Objective: How many participants of the German National Cohort Study (GNC; NAKO Gesundheitsstudie) were annoyed by transportation noise during nighttime and what factors were associated with noise annoyance?, Materials and Methods: This cross-sectional analysis included 86,080 participants from 18 study centers, examined from 2014 to 2017. We used multinomial logistic regression to investigate associations of personal and regional factors to noise annoyance (slightly/moderately or strongly/extremely annoyed vs. not annoyed) mutually adjusting for all factors in the model., Results: Two thirds of participants were not annoyed by transportation noise during nighttime and one in ten reported strong/extreme annoyance with highest percentages for the study centers Berlin-Mitte and Leipzig. The strongest associations were seen for factors related to the individual housing situation like the bedroom being positioned towards a major road (OR of being slightly/moderately annoyed: 4.26 [95% CI: 4.01;4.52]; OR of being strongly/extremely annoyed: 13.36 [95% CI: 12.47;14.32]) compared to a garden/inner courtyard. Participants aged 40-60 years and those in low- and medium-income groups reported greater noise annoyance compared to younger or older ones and those in the high-income group., Conclusion: In this study from Germany, transportation noise annoyance during nighttime varied by personal and regional factors.
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- 2020
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16. [Socio-demographic and employment-related factors in the German National Cohort (GNC; NAKO Gesundheitsstudie)].
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Dragano N, Reuter M, Greiser KH, Becher H, Zeeb H, Mikolajczyk R, Kluttig A, Leitzmann M, Fischer B, Jöckel KH, Emmel C, Krause G, Castell S, Damms-Machado A, Obi N, Schikowski T, Kuss O, Hoffmann W, Schipf S, Pischon T, Jaeschke L, Krist L, Keil T, Lieb W, Holleczek B, Brenner H, Wirkner K, Loeffler M, Michels KB, Franzke CW, Peters A, Linseisen J, Berger K, Legath N, Ahrens W, Lampert T, and Schmidt B
- Subjects
- Cohort Studies, Female, Germany, Humans, Male, Middle Aged, Socioeconomic Factors, Unemployment, Employment, Health Status
- Abstract
Background: In epidemiologic studies, standardised measurement of socio-demographic and employment-related factors is becoming increasingly important, as variables such as gender, age, education or employment status are factors influencing health and disease risks., Aims: The article gives an overview of the scientific background and assessment of socio-demographic factors in the German National Cohort Study. In addition, the distribution of individual characteristics in the cohort as well as relationships with health-related measures are presented by way of example., Material and Methods: The analysis is based on the data of the first half of the baseline survey (n = 101,724). On this basis, we present the distribution of key socio-demographic characteristics and analyse relationships with exemplary selected health indicators (body mass index, self-reported health) to assess the validity of socio-demographic data measurements., Results: On average, study participants were 52.0 years old (SD = 12.4). Of the participants, 53.6% were women, 54.3% had high education, 60.1% were married and 72% were employed while 3.4% were unemployed. Well-established correlations between socio-demographic factors and health could be reproduced with the German National Cohort data. For example, low education, old age and unemployment were associated with an increased prevalence of obesity and poor self-reported health., Discussion: The German National Cohort provides a comprehensive measurement of socio-demographic characteristics. Combined with a wide range of health data and the longitudinal measurements available in the future, this opens up new opportunities for health science and social epidemiological research in Germany.
- Published
- 2020
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17. [Measuring physical fitness in the German National Cohort-methods, quality assurance, and first descriptive results].
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Kluttig A, Zschocke J, Haerting J, Schmermund A, Gastell S, Steindorf K, Herbolsheimer F, Hillreiner A, Jochem C, Baumeister S, Sprengeler O, Pischon T, Jaeschke L, Michels KB, Krist L, Greiser H, Schmidt G, Lieb W, Waniek S, Becher H, Jagodzinski A, Schipf S, Völzke H, Ahrens W, Günther K, Castell S, Kemmling Y, Legath N, Berger K, Keil T, Fricke J, Schulze MB, Loeffler M, Wirkner K, Kuß O, Schikowski T, Kalinowski S, Stang A, Kaaks R, Damms Machado A, Hoffmeister M, Weber B, Franzke CW, Thierry S, Peters A, Kartschmit N, Mikolajczyk R, Fischer B, Leitzmann M, and Brandes M
- Subjects
- Adult, Female, Germany, Hand Strength, Humans, Male, Oxygen, Oxygen Consumption, Young Adult, Exercise Test, Physical Fitness
- Abstract
Physical fitness is defined as an individual's ability to be physically active. The main components are cardiorespiratory fitness (CRF), muscle strength, and flexibility. Regardless of physical activity level, physical fitness is an important determinant of morbidity and mortality.The aim of the current study was to describe the physical fitness assessment methodology in the German National Cohort (NAKO) and to present initial descriptive results in a subsample of the cohort.In the NAKO, hand grip strength (GS) and CRF as physical fitness components were assessed at baseline using a hand dynamometer and a submaximal bicycle ergometer test, respectively. Maximum oxygen uptake (VO
2max ) was estimated as a result of the bicycle ergometer test. The results of a total of 99,068 GS measurements and 3094 CRF measurements are based on a data set at halftime of the NAKO baseline survey (age 20-73 years, 47% men).Males showed higher values of physical fitness compared to women (males: GS = 47.8 kg, VO2max = 36.4 ml·min-1 · kg-1 ; females: GS = 29.9 kg, VO2max = 32.3 ml · min-1 · kg-1 ). GS declined from the age of 50 onwards, whereas VO2max levels decreased continuously between the age groups of 20-29 and ≥60 years. GS and VO2max showed a linear positive association after adjustment for body weight (males β = 0.21; females β = 0.35).These results indicate that the physical fitness measured in the NAKO are comparable to other population-based studies. Future analyses in this study will focus on examining the independent relations of GS and CRF with risk of morbidity and mortality.- Published
- 2020
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18. [Lung function in the German National Cohort: methods and initial results].
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Karrasch S, Peters A, Meisinger C, Ferland M, Jaeschke L, Pischon T, Fricke J, Keil T, Gastell S, Schulze M, Brandes M, Günther K, Kuß O, Schikowski T, Emmel C, Jöckel KH, Michels KB, Franzke CW, Langer S, Mikolajczyk R, Jagodzinski A, Becher H, Castell S, Kemmling Y, Waniek S, Lieb W, Wirkner K, Loeffler M, Greiser KH, Kaaks R, Legath N, Berger K, Schipf S, Hoffmann W, Sedlmeier A, Leitzmann M, Brenner H, Holleczek B, and Schulz H
- Subjects
- Asthma, Exhalation, Germany, Humans, Spirometry, Breath Tests
- Abstract
Background: A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset., Material and Methods: The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves., Results: In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV
1 Z score (according to GLI 2012) was -0.321 ± 1.047, the FVC Z score was -0.153 ± 0.941, and the FEV1 /FVC Z score was -0.337 ± 0.901. The difference in FEV1 /FVC between current smokers and never-smokers increased with age. The average FeNO was 14.2 ÷ 2.0 ppb. Current smoking reduced FeNO levels by 43%, whereas respiratory allergy increased FeNO levels by 16% in nonsmokers., Discussion: The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.- Published
- 2020
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19. [Current recommendations for surveillance, risk reduction and therapy in Lynch syndrome patients].
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Hüneburg R, Aretz S, Büttner R, Daum S, Engel C, Fechner G, Habermann JK, Heling D, Hoffmann K, Holinski-Feder E, Kloor M, von Knebel-Döberitz M, Loeffler M, Möslein G, Perne C, Redler S, Rieß O, Schmiegel W, Seufferlein T, Siebers-Renelt U, Steinke-Lange V, Tecklenburg J, Vangala D, Vilz T, Weitz J, Wiedenmann B, Strassburg CP, and Nattermann J
- Subjects
- Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Germany, Humans, Population Surveillance, Time Factors, Colorectal Neoplasms, Hereditary Nonpolyposis pathology, DNA Mismatch Repair, Endoscopy, Digestive System methods, Practice Guidelines as Topic, Risk Reduction Behavior
- Abstract
Introduction: Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome and accounts for ~3 % of all CRCs. This autosomal dominant disorder is caused by germline mutations in DNA mismatch repair genes ( MLH1, MSH2, MSH6, PMS2 , and EPCAM ). One in 300 individuals of the general population are considered to be mutation carriers (300 000 individuals/Germany). Mutation carriers are at a high CRC risk of 15-46 % till the age of 75 years. LS also includes a variety of extracolonic malignancies such as endometrial, small bowel, gastric, urothelial, and other cancers., Methods: The German Consortium for Familial Intestinal Cancer consists of 14 university centers in Germany. The aim of the consortium is to develop and evaluate surveillance programs and to further translate the results in clinical care. We have revisited and updated the clinical management guidelines for LS patients in Germany., Results: A surveillance colonoscopy should be performed every 12-24 months starting at the age of 25 years. At diagnosis of first colorectal cancer, an oncological resection is advised, an extended resection (colectomy with ileorectal anastomosis) has to be discussed with the patient. The lifetime risk for gastric cancer is 0.2-13 %. Gastric cancers detected during surveillance have a lower tumor stage compared to symptom-driven detection. The lifetime risk for small bowel cancer is 4-8 %. About half of small bowel cancer is located in the duodenum and occurs before the age of 35 years in 10 % of all cases. Accordingly, patients are advised to undergo an esophagogastroduodenoscopy every 12-36 months starting by the age of 25 years., Conclusion: LS colonic and extracolonic clinical management, surveillance and therapy are complex and several aspects remain unclear. In the future, surveillance and clinical management need to be more tailored to gene and gender. Future prospective trials are needed., Competing Interests: Die Autoren geben an, dass kein Interessenkonflikt besteht., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2019
- Full Text
- View/download PDF
20. [The Prevalence of Current Depressive Symptoms in an Urban Adult Population].
- Author
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Luck T, Then FS, Engel C, Loeffler M, Thiery J, Villringer A, and Riedel-Heller SG
- Subjects
- Adolescent, Adult, Aged, Cross-Sectional Studies, Depression diagnosis, Depression psychology, Depressive Disorder diagnosis, Depressive Disorder psychology, Female, Germany, Humans, Male, Middle Aged, Population Surveillance, Socioeconomic Factors, Young Adult, Depression epidemiology, Depressive Disorder epidemiology, Urban Population statistics & numerical data
- Abstract
Objective We sought to provide prevalence rates of depressive symptoms in the adult population of the city of Leipzig, Germany (18 - 79 years; N = 8,861). Methods Data were derived from the Leipzig population-based study of adults (LIFE-ADULT-Study). The German version of the Center for Epidemiological Studies Depression Scale (CES-D) was used to assess depressive symptoms using a cut-off score ≥ 23 points. Results The prevalence of current depressive symptoms was 6.4 % (95 %-KI = 5.4 - 7.4). Significantly higher prevalence rates were found in females than in males, in individuals in middle age (40 - 59 years) than in younger and older adults as well as in those individuals with lower socioeconomic status (SES). Conclusion The study findings did not indicate a generally increased risk of depressive symptoms in urban-living adults., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2017
- Full Text
- View/download PDF
21. [Juvenile ossifying fibroma of the facial skull. Computerized tomography and nuclear magnetic resonance tomography].
- Author
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Römer T, Berger T, Berghaus A, and Loeffler M
- Subjects
- Adolescent, Biopsy, Female, Humans, Orbit pathology, Paranasal Sinuses pathology, Magnetic Resonance Imaging, Orbital Neoplasms pathology, Paranasal Sinus Neoplasms pathology, Tomography, X-Ray Computed
- Abstract
The clinical and radiological features in a case of a juvenile ossifying fibroma of the skull were studied with CT and MRI. The combination of both imaging modalities allows a precise prediction of tumor components and extension.
- Published
- 1987
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