1. [Acetylsalicylic acid does not alter the mechanoelectrical transduction of mammalian outer hair cells in vitro].
- Author
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Preyer S and Meyer J
- Subjects
- Animals, Cells, Cultured, Dose-Response Relationship, Drug, Evoked Potentials, Auditory drug effects, Guinea Pigs, Hair Cells, Auditory, Outer drug effects, Mechanotransduction, Cellular drug effects, Membrane Potentials drug effects, Aspirin administration & dosage, Evoked Potentials, Auditory physiology, Hair Cells, Auditory, Outer physiology, Mechanotransduction, Cellular physiology, Membrane Potentials physiology
- Abstract
Background: High doses of acetylsalicylic acid (ASS) induce tinnitus and hearing loss. This ototoxic side effect of ASS is characterized by a decrease in spontaneous and evoked otoacoustic emissions. A decrease in otoacoustic emissions is found not only in mammals, but also in non-mammalian ears without electromotile outer hair cells. The molecular mechanism underlying ASS ototoxicity seems to be competitive binding to and a block of the motor molecule prestin. In non-mammalian species, ASS ototoxicity is possibly explained by an effect on the hair bundle., Results: The present data from the outer hair cells of the adult guinea pig cochlea show a reduction in the membrane capacitance by maximally 42%, probably as a result of ASS binding competitively to the motor molecule. However, spontaneous and evoked receptor currents were not modulated by ASS., Conclusion: The results suggest an influence of ASS on outer hair cell somatic electromotility, without a concomitant effect on hair-bundle function.
- Published
- 2006
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