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Background:  As has been proven by numerous studies, people with gender identity disorders have a reduced quality of life. Considerable psychological strain leads to depressive and anxiety disorders and increased suicidal tendencies compared with the normal population. In addition, social limitations reduce the quality of life. More and more transsexual people use the possibility of undergoing gender reassignment surgery. However, this surgery means a radical change in a patient's life. This work aims to analyse whether surgical interventions help to improve the quality of and satisfaction with life of transmen and transwomen in a long-lasting way., Methods:  A systematic literature search was conducted using the PubMed, Embase and Cochrane Library databases. Our analysis only included original retrospective or prospective studies concerning the quality of life after gender reassignment surgery., Results:  Twenty-seven studies were included. Quality of life was analysed retrospectively in 20 studies and prospectively in 7 studies. Four publications studied only transmen, 11 studied only transwomen, and 12 studied both. The totality of all studies examined 1849 transwomen and 869 transmen. Changes in quality of life were measured by different validated questionnaires. A significant improvement in quality of life was shown in the subareas mental, physical and social health. It was proven that patients were more satisfied with their own bodies and genders and had a higher quality of life in general.Even after gender reassignment surgery, the rates of mental disorders and mortality remained increased. Compared with the normal population, the quality of life of transsexual people was reduced., Conclusion:  Numerous studies have proven that gender reassignment surgery helps to reduce the level of suffering in transmen and transwomen. Satisfaction with life, mental and physical health as well as social life improve after surgical treatment combined with endocrinologic and psychological treatment. However, compared with the normal population, the quality of life of transsexual people lags behind., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (Thieme. All rights reserved.)