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1. The permeability of the synovial membrane for proteins is larger in rheumatoid arthritis than in osteoarthrosis, in rheumatoid arthritis with high CRP activity larger than in rheumatoid arthritis with low CRP activity. 2. The diffusion by the synovial membrane in most plasma proteins takes place depending on their molecular weight. Of the 14 proteins tested only haptoglobin and fibrinogen did not follow this regularity. 3. While the non-immune proteins proved in the synovial fluid only come from the blood plasma, the immune globulins IgG, IgA, and IgM as well as lysozyme are partly also locally synthetized and enriched in rheumatoid arthritis. In rheumatoid arthritis lysozyme is present in the synovia not only in free, but in most cases also in cell-bound form.

Lysozyme formation induced by bacteriophage T3 was studied in the ts-mutant E. coli CRT 266 (dnaBts) and in the wild-type E. coli CR 34--45 (dnaB+) at different temperatures. It was found that lysozyme was formed in E. coli CRT 266, however, no lysozyme synthesis took place at 41.5 degrees C. These results indicate that the expression of the lysozyme gene is disturbed in the ts-mutant at 41.5 degrees C.