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Start Over Descriptor "Oncogenic signaling" Language german
1 results on '"Oncogenic signaling"'

1. Inhibition von Heat-shock Protein 90 (Hsp90) mittels EC154, einem neuen synthetischen Hsp90 Antagonist, reduziert das Wachstum von humanen Magen- und Pankreaskarzinomzellen in vivo

Author

Edward K. Geissler, Hong Zhang, HJ Schlitt, Sa Lang, O. Stöltzing, Francis Burrows, Ulrich Bolder, and Christian Moser

Subjects
MAPK/ERK pathway, biology, ddc: 610, Chemistry, Heat shock protein, Oncogenic signaling, biology.protein, Growth inhibitory, Hsp90, Protein kinase B, Transcription factor, Hsp90 inhibitor, Cell biology
Abstract

Heat shock protein 90 (Hsp90) has been identified to be crucial for stability and functionality of oncogenic signaling molecules, including EGFR, Her-2, Akt, Erk, and various transcription factors. Here we investigated growth inhibitory effects of a novel synthetic Hsp90 inhibitor (EC154) in gastrointestinal cancers.

Published
2008

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