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4 results on '"Pezzella A"'

1. Pessoa como Sujeito de Direitos na Sociedade da Informação: garantia fundamental de proteção à dignidade da pessoa humana face ao valor social do trabalho

Author

Maria Cristina Cereser Pezzella and Michelle Dias Bublitz

Subjects
Pessoa, Sujeitos de direitos, Sociedade da informação, Dignidade da pessoa humana, Trabalho, Law, Law in general. Comparative and uniform law. Jurisprudence, K1-7720
Abstract

http://dx.doi.org/10.5007/2177-7055.2013v35n68p239O presente artigo possui o escopo de demonstrar que, sem dúvida, diversos movimentos e fenômenos não jurídicos, mas com impactos importantes nessa seara, trouxeram à baila a discussão acerca da garantia fundamental de proteção à dignidade da pessoa humana enquanto sujeito de direitos. Nesse sentido, destaca-se como princípio basilador dessa iniciativa o princípio constitucional da igualdade, como resposta à necessidade de conferir-se efetividade ao direito ao trabalho de todos os grupos sociais, na medida em que o direito à igualdade, por considerar positivamente as diferenças humanas, é o verdadeiro alicerce de todos os direitos constitucionalmente conferidos às pessoas.

Published
2014
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2. [Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)]

Author

Lorenzen, J, Hansmann, ML, Shibata, D, Hell, K, Klöckner, A, Pezzella, F, and Fischer, R

Subjects
hemic and lymphatic diseases
Abstract

We have investigated seven cases of large cell lymphomas (LCL) developing simultaneously or metachronously to nodular lymphocyte-predominant Hodgkin's disease (nodular paragranuloma, NP) for the presence of EBV and the chromosomal translocation t(14;18) by use of the polymerase chain reaction (PCR). The expression of the bcl-2 oncogene product in these cases and in five cases of progressive transformation of germinal centres as a potential precursor of NP was detected immunohistochemically with the monoclonal antibodies bcl-2-100 and bcl-2-124. All cases investigated were negative for EBV genomic material. The chromosomal translocation t(14;18) was also absent. Expression of the bcl-2 oncogene could be detected only in one case of nodular paragranuloma and in an unrelated case of LCL. Hence, LCL developing out of NP differ from other germinal center derived high-grade lymphomas.

Published
2016

3. Effect of anagrelide on JAK2 mutational status in patients with essential thrombocythemia

Author

Ernesto Di Francesco, Emma Cacciola, Rossella R. Cacciola, Francesca Pezzella, and Daniele Tibullo

Subjects
medicine.medical_specialty, Essential thrombocythemia, business.industry, Jak2 mutation, food and beverages, General Medicine, Anagrelide, Pharmacology, medicine.disease, Gastroenterology, Polycythemia vera, hemic and lymphatic diseases, Internal medicine, Mutation (genetic algorithm), medicine, Mutational status, In patient, business, JAK2 V617F, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

We evaluated the effect of anagrelide (ANA) in 9 of 22 patients with essential thrombocythemia (ET) who had a JAK2 V617F mutation and polycythemia vera (PV)–like disease. First, we observed a successful reduction of JAK2 mutation, which was associated with disappearance of PV-like phenotype. Second, we found that a level of JAK2 mutation

Published
2008

4. [Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)]

Author

J, Lorenzen, M L, Hansmann, D, Shibata, K, Hell, A, Klöckner, F, Pezzella, and R, Fischer

Subjects
Adult, Chromosomes, Human, Pair 14, Male, Herpesvirus 4, Human, Lymphoma, B-Cell, Genetic Variation, Nuclear Proteins, Oncogenes, Middle Aged, Hodgkin Disease, Translocation, Genetic, DNA-Binding Proteins, Epstein-Barr Virus Nuclear Antigens, Proto-Oncogene Proteins c-bcl-2, Antigens, Neoplasm, GTP-Binding Proteins, Proliferating Cell Nuclear Antigen, Proto-Oncogene Proteins, Humans, Female, Lymphoma, Large B-Cell, Diffuse, Chromosomes, Human, Pair 18, Antigens, Viral, Aged
Abstract

We have investigated seven cases of large cell lymphomas (LCL) developing simultaneously or metachronously to nodular lymphocyte-predominant Hodgkin's disease (nodular paragranuloma, NP) for the presence of EBV and the chromosomal translocation t(14;18) by use of the polymerase chain reaction (PCR). The expression of the bcl-2 oncogene product in these cases and in five cases of progressive transformation of germinal centres as a potential precursor of NP was detected immunohistochemically with the monoclonal antibodies bcl-2-100 and bcl-2-124. All cases investigated were negative for EBV genomic material. The chromosomal translocation t(14;18) was also absent. Expression of the bcl-2 oncogene could be detected only in one case of nodular paragranuloma and in an unrelated case of LCL. Hence, LCL developing out of NP differ from other germinal center derived high-grade lymphomas.

Published
1992

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