Descriptor: "Platinum(IV) prodrugs" / Language: german - Searchworks@Jio Institute Digital Library Search Results

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Start Over Descriptor "Platinum(IV) prodrugs" Language german

Author: Jun Xiang Ong, Siew Qi Yap, Daniel Yuan Qiang Wong, Chee Fei Chin, and Wee Han Ang
Subjects: Anticancer, Cisplatin, Oxaliplatin, Platinum(iv) prodrugs, Targeted chemotherapy, Chemistry, QD1-999
Abstract: Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs. Being native prodrugs of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact. This mini-review examines recent work performed to illuminate the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.
Published: 2015
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Author: Chee Fei Chin, Daniel Yuan Qiang Wong, Wee Han Ang, Jun Xiang Ong, and Siew Qi Yap
Subjects: Chemotherapy, Chemistry, Stereochemistry, medicine.medical_treatment, chemistry.chemical_element, General Medicine, General Chemistry, Prodrug, Oxaliplatin, chemistry.chemical_compound, Anticancer, Platinum(iv) prodrugs, medicine, Targeted chemotherapy, Carboxylate, Pharmacophore, Cisplatin, Platinum, QD1-999
Abstract: Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs. Being native prodrugs of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact. This mini-review examines recent work performed to illuminate the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.
Published: 2015

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