Search

Your search keyword '"Receptors, Autocrine Motility Factor"' showing total 2 results
Start Over Descriptor "Receptors, Autocrine Motility Factor" Language german
2 results on '"Receptors, Autocrine Motility Factor"'

1. [Principles of tumor invasion and metastasis]

Author

T, Otto, M, Goepel, F, Recker, and H, Rübben

Subjects
Carcinoma, Transitional Cell, Ubiquitin-Protein Ligases, Urinary Bladder, Down-Regulation, Cadherins, Prognosis, Disease-Free Survival, Gene Expression Regulation, Neoplastic, Receptors, Autocrine Motility Factor, Urinary Bladder Neoplasms, Humans, Neoplasm Invasiveness, Prospective Studies, Neoplasm Metastasis, Receptors, Cytokine, Neoplasm Staging, Retrospective Studies
Abstract

Histopathological and clinical parameters are of limited value in characterization of the individual course of disease in bladder cancer patients. Down-regulation of E-cadherin, an intercellular adhesion molecule, and upregulation of autocrine motility factor receptor (AMFR) expression have been shown to play a part in tumour cell invasion and metastasis. In a retrospective analysis concerning 95 different bladder specimens and a prospective study in 100 bladder cancer patients, reduction in E-cadherin concomitantly with an increase in AMFR expression was associated with a poor prognosis. The dual use of these two antigens may improve early diagnosis of high-risk bladder cancer patients and influence treatment decisions.

Published
1995

2. [Principles of tumor invasion and metastasis].

Author

Otto T, Goepel M, Recker F, and Rübben H

Subjects
Carcinoma, Transitional Cell mortality, Carcinoma, Transitional Cell pathology, Carcinoma, Transitional Cell surgery, Disease-Free Survival, Down-Regulation genetics, Gene Expression Regulation, Neoplastic physiology, Humans, Neoplasm Invasiveness genetics, Neoplasm Metastasis genetics, Neoplasm Staging, Prognosis, Prospective Studies, Receptors, Autocrine Motility Factor, Retrospective Studies, Ubiquitin-Protein Ligases, Urinary Bladder pathology, Urinary Bladder Neoplasms mortality, Urinary Bladder Neoplasms pathology, Urinary Bladder Neoplasms surgery, Cadherins genetics, Carcinoma, Transitional Cell genetics, Receptors, Cytokine genetics, Urinary Bladder Neoplasms genetics
Abstract

Histopathological and clinical parameters are of limited value in characterization of the individual course of disease in bladder cancer patients. Down-regulation of E-cadherin, an intercellular adhesion molecule, and upregulation of autocrine motility factor receptor (AMFR) expression have been shown to play a part in tumour cell invasion and metastasis. In a retrospective analysis concerning 95 different bladder specimens and a prospective study in 100 bladder cancer patients, reduction in E-cadherin concomitantly with an increase in AMFR expression was associated with a poor prognosis. The dual use of these two antigens may improve early diagnosis of high-risk bladder cancer patients and influence treatment decisions.

Published
1995

Catalog

Books, media, physical & digital resources
See catalog results