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Your search keyword '"Schenker, E."' showing total 9 results
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9 results on '"Schenker, E."'

4. [Bicyclic 3-hydrazinopyridazines with antihypertensive action (author's transl)].

Author

Schenker E and Salzmann R

Subjects
Animals, Blood Pressure drug effects, Chemical Phenomena, Chemistry, Hypertension, Renal drug therapy, Pyridazines pharmacology, Rats, Structure-Activity Relationship, Antihypertensive Agents chemical synthesis, Pyridazines chemical synthesis
Abstract

The synthesis of a series of 3-hydrazinopyridazines is described. Several of these compounds exhibited high antihypertensive activity in the rat. The most potent member of the series is l-benzoyl-3-hydrazino-5,6,7,8-tetrahydropyrido-[4,3-c]pyridazine, compound 28 [1], which is now under clinical trial [2] under the clinical code number BQ 22-708 (endrazaline, Miretilan). It was possible to discover certain structure-activity relationships.

Published
1979

5. [Value of the 14C-aminophenazone inhalation test: inhibition of the demethylation function of the liver by cimetidine].

Author

Schenker E, Haustein KO, and Schenker U

Subjects
Adult, Cimetidine therapeutic use, Cytochrome P-450 Enzyme Inhibitors, Female, Humans, Inactivation, Metabolic, Male, Microsomes, Liver enzymology, Middle Aged, Aminopyrine metabolism, Cimetidine adverse effects, Duodenal Ulcer drug therapy, Liver Function Tests methods, Microsomes, Liver drug effects, Stomach Ulcer drug therapy
Abstract

On 15 patients with healthy liver and with a peptic ulcer the demethylation capacity of the liver was measured with the 14C-aminophenazone breathing test before the treatment and during the treatment with the H2-antagonist cimetidine (daily dose 1.0 g). As measure of the demethylation capacity the breathed out 14CO2 (DPM/mmol CO2/70 kg body weight) before and 1 hour after intake was chosen. Under influence of cimetidine the mean 14CO2-value of 724.7 DPM (S.D. 127.7) decreased to 404.1 DPM (S. D. 153.1). The enzyme activities (ALAT, ASAT, AP, AAP, GGT, CHE) and the concentrations of serum bilirubin and serum albumin remained unchanged and did not correlate mutually and with the 14CO2-data. The results confirm the independence of the aminophenazone test as technique for the recognition of disturbance of the MFO-system.

Published
1986

9. [Pregnancy in heart diseases from the internist's viewpoint].

Author

Schenker E and Seyffert C

Subjects
Angina Pectoris diagnosis, Aortic Valve Stenosis diagnosis, Female, Heart Auscultation, Heart Septal Defects, Atrial, Humans, Mitral Valve Insufficiency diagnosis, Pregnancy, Prenatal Care, Heart Diseases diagnosis, Pregnancy Complications, Cardiovascular diagnosis
Published
1970

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