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Chronic renal insufficiency was induced in rats by a five-sixths nephrectomy, and then incisional wounds were made in the abdominal skin, linea alba, stomach and colon. Morphologically, there was no significant retardation of wound healing in the uremic rats, although a slight delay was evident in the beginning of the healing process and inflammmatory cells were more increased in number in uremic rats. Bursting strength of the colon and tensile strength of the skin, aponeurosis an stomach were usually less in the uremia than in the control, but there was no statistical significance except in colonic wounds after 5 days. It was also observed that the amount of hydroxyproline present in the uremic rats was less without statistical significance except in colonic wounds at 5 and 6.5 days. However, no correlation was established between blood urea nitrogen and microscopic findings of the wounds, nor between tissue strength and hydroxyproline. Nevertheless our investigations indicate the relative significiance of the hydroxyproline concentration for processes of wound healing. Transferring theses results to man, patients suffering from chronic uremia are throughly operable if a more careful choice of surgical technique and avoidance of possible wound infections is observed.