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4. Tumor type resulting in upgrade: An analysis based on 333 low grade soft tissue sarcoma

Author

Langer, Stefan, Spindler, Nick, Steinau, Hans Ulrich, Tannapfel, Andrea, and Stricker, Ingo

Subjects
Surgery, RD1-811
Abstract

[english] Introduction: Soft tissue sarcomas (STS) are rare tumors. Based on histopathological criteria, three grades are distinguished from low (G1) to intermediate (G2) and high grade (G3). After complete initial surgical resection, some G1 STS recur as lesions with an upgrade of a previous G1 STS to a recurrent G2 STS. This upgrade indicates higher malignancy of the STS. Our aim was to find possible risk factors for these upgrades including age, localization of tumor and tumor type. Methods: This retrospective case-control study evaluated 333 patients. Of these 333, 54.7% were male and 45.3% female. All patients underwent R0 resections and among these, 10% subsequently upgraded. The processed data include age, gender, tumor type, tumor localization, local recurrence and upgrade. Results: Patients with upgrades have a higher mean age of 5.5 years than our reference collective. The tumor type has a significant effect on upgrades. Patients with fibrosarcomas are at a threefold risk of an upgrade compared to patients with other G1 STS.Conclusion: Our results indicate that age and tumor type play a key role in upgrades in G1 STS. Patients, age 60 and above and diagnosed with G1 fibrosarcomas, are three times as likely to upgrade compared to patients younger than 60 with other G1 STS. We discuss the significance of these risk factors and whether aside from complete tumor resection, additional therapies (e.g. irradiation) may be applied to improve therapeutic outcome.

Published
2014
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12. S3-Leitlinie Exokrines Pankreaskarzinom – Version 3.1.

Author

Seufferlein, Thomas, Mayerle, Julia, Boeck, Stefan, Brunner, Thomas, Ettrich, Thomas J., Grenacher, Lars, Gress, Thomas Mathias, Hackert, Thilo, Heinemann, Volker, Kestler, Angelika, Sinn, Marianne, Tannapfel, Andrea, Wedding, Ulrich, and Uhl, Waldemar

Published
2024
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19. Amendment „Neue Nomenklatur zur MASLD (Metabolic Dysfunction Associated Steatotic Liver Disease; metabolische Dysfunktion assoziierte steatotische Lebererkrankung) " zur S2k-Leitlinie „Nicht-alkoholische Fettlebererkrankung" (v.2.0/April 2022) der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

Author

Roeb, Elke, Canbay, Ali, Bantel, Heike, Bojunga, Jörg, de Laffolie, Jan, Demir, Münevver, Denzer, Ulrike W., Geier, Andreas, Hofmann, Wolf Peter, Hudert, Christian, Karlas, Thomas, Krawczyk, Marcin, Longerich, Thomas, Lüdde, Tom, Roden, Michael, Schattenberg, Jörn M., Sterneck, Martina, Tannapfel, Andrea, Lorenz, Pia, and Tacke, Frank

Published
2024
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32. S3-Leitlinie Diagnostik und Therapie biliärer Karzinome

Author

Bitzer, Michael, Groß, Sabrina, Albert, Jörg, Boda-Heggemann, Judit, Brunner, Thomas, Caspari, Reiner, De Toni, Enrico, Dombrowski, Frank, Evert, Matthias, Geier, Andreas, Gkika, Eleni, Götz, Martin, Helmberger, Thomas, Hoffmann, Ralf-Thorsten, Huppert, Peter, Kautz, Achim, Krug, David, Fougère, Christian La, Lang, Hauke, Lenz, Philipp, Lüdde, Tom, Mahnken, Andreas, Nadalin, Silvio, Nguyen, Hoa Huu Phuc, Ockenga, Johann, Oldhafer, Karl, Paprottka, Philipp, Pereira, Philippe, Persigehl, Thorsten, Plentz, Ruben, Pohl, Jürgen, Recken, Heinrich, Reimer, Peter, Riemer, Jutta, Ritterbusch, Ulrike, Roeb, Elke, Rüssel, Jörn, Schellhaas, Barbara, Schirmacher, Peter, Schlitt, Hans Jürgen, Schmid, Irene, Schuler, Andreas, Seehofer, Daniel, Sinn, Marianne, Stengel, Andreas, Stoll, Christoph, Tannapfel, Andrea, Taubert, Anne, Tholen, Reina, Trojan, Jörg, van Thiel, Ingo, Vogel, Arndt, Vogl, Thomas, Wacker, Frank, Waidmann, Oliver, Wedemeyer, Heiner, Wege, Henning, Wildner, Dane, Wörns, Marcus-Alexander, Galle, Peter, and Malek, Nisar

Subjects
Medizin
Published
2023

33. S3-Leitlinie Diagnostik und Therapie biliärer Karzinome : Langversion

Author

Michael Bitzer, Sabrina Groß, Jörg Albert, Judit Boda-Heggemann, Thomas Brunner, Reiner Caspari, Enrico De Toni, Frank Dombrowski, Matthias Evert, Andreas Geier, Eleni Gkika, Martin Götz, Thomas Helmberger, Ralf-Thorsten Hoffmann, Peter Huppert, Achim Kautz, David Krug, Christian La Fougère, Hauke Lang, Philipp Lenz, Tom Lüdde, Andreas Mahnken, Silvio Nadalin, Hoa Huu Phuc Nguyen, Johann Ockenga, Karl Oldhafer, Philipp Paprottka, Philippe Pereira, Thorsten Persigehl, Ruben Plentz, Jürgen Pohl, Heinrich Recken, Peter Reimer, Jutta Riemer, Ulrike Ritterbusch, Elke Roeb, Jörn Rüssel, Barbara Schellhaas, Peter Schirmacher, Hans Jürgen Schlitt, Irene Schmid, Andreas Schuler, Daniel Seehofer, Marianne Sinn, Andreas Stengel, Christoph Stoll, Andrea Tannapfel, Anne Taubert, Reina Tholen, Jörg Trojan, Ingo van Thiel, Arndt Vogel, Thomas Vogl, Frank Wacker, Oliver Waidmann, Heiner Wedemeyer, Henning Wege, Dane Wildner, Marcus-Alexander Wörns, Peter Galle, and Nisar Malek

Subjects
Gastroenterology, Medizin
Published
2023

49. Ösophagustumoren

Author

Menges, M., Anthuber, Matthias, Geißler, Bernd, Probst, A., Stüben, Georg, Tannapfel, A., and Messmann, Helmut

Published
2022

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