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Two patients treated topically against dermatophytes with a naftifine containing antifungal became allergic to the efficacious component naftifine. One of them also reacted to benzyl alcohol. Sensitization experiments in guinea pigs corroborated the suspicion that this allylamine is a contact sensitizer. To date, only few cases of allergic reactions to naftifine have been reported.

In a placebo-controlled double-blind comparative study conducted in 19 healthy volunteers, naftifin hydrochlorid cream was tested against clotrimazole 1%, clotrimazole 1%+hydrocortisone 1%, and various hydrocortisone preparations (0.5%; 1%; 2.5%) for erythema-suppressive effects. The anti-inflammatory effect of naftifine hydrochloride demonstrated earlier was confirmed in this study. The results prove a potency comparable to that of weak topical glucocorticosteroids.

The antimycotic efficacy of Naftifine was compared with that of placebo in a double-blind randomized trial in 60 patients with Tinea pedum proved by culture and microscopic examination. Naftifine was significantly superior to placebo concerning the number of mycologically cured patients as well as the clinical response to therapy. At the end of the study all patients were cured by Naftifine, whereas no patient of the placebo group showed an improvement.

Naftifine, an allylamine derivative, represents a new class of antimycotic agents. During a multicentric, double blind, intraindividual, contralateral comparison study, 126 patients with dermatophytosis or candidosis were examined with regard to antimycotic efficacy and local tolerance of Naftifine cream or Clotrimazole cream. After treatment with Naftifine for 7 days, 63.5% of the patients were mycologically cured, whereas 56% were cured with the help of Clotrimazole. After 2 weeks, the healing rate amounted to 84% under both drugs. At that time, 95% of the patients showed negative cultures on both corresponding body sites. Regarding the improvement of the clinical symptoms and the frequency of relapses occurring 4 weeks after the end of treatment as well as local side effects, there was no substantial difference between both drugs. The "responder-rate" towards Naftifine, however, was higher by the end of treatment. The local tolerance of both drugs was excellent or good on more than 90% of the patients.