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Introduction: This article summarizes the recommendations of the Israeli Neurogastroenterology and Motility Branch of the Israeli Gastroenterology Association for diagnosis and treatment of chronic constipation. It encompasses an overview of the definitions, the diagnostic approach and the possible treatment options in chronic constipation. This document is suitable for primary care physicians who are interested in understanding the major physiologic mechanisms for chronic constipation and the possible treatment options, as well as for the gastroenterology consultant who faces patients with tenacious chronic constipation.