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This chapter presents suicide as a preventable phenomenon among adolescents. We describe suicide risk assessment, which is a clinical assessment that every mental health provider should master. The article also describes the three levels of suicide prevention. Primary prevention includes immunization of the whole population. It includes gatekeepers training among school students, hotlines which specialize in suicide prevention, restriction of access to lethal means and continuity of care. Secondary prevention includes psychosocial and pharmacological treatments for at-risk adolescents such as those suffering from depression. Mental health providers should be trained to reduce depression among adolescents in evidence-based interventions and even aim to prevent depression in psychotherapy. It is crucial that parents play a major role in these interventions. Tertiary prevention includes treating adolescents after a suicide attempt and providing postvention in communities and organizations in which a suicide occurred in order to reduce the risk of contagion. It is very important that providers know how to work with at-risk adolescents, their parents, and schools in order to focus specifically on suicide prevention. These interventions require knowledge, experience, teamwork and a high level of empathy and hope and thus have potential to save lives. [ABSTRACT FROM AUTHOR]