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Introduction: The disorders of digestion and absorption are broadly covered under the heading of “Grahani roga” in Ayurvedic classics. Grahani is the seat of agni. It retains the food till the food is fully digested and passed to Pakvashaya. Mandagni (weak digestive fire) causes improper digestion of food and leads to Grahani roga. In Grahani roga, mala is released in undigested form. The role of diet and Deepana-Pachana is very important, while treating the patient of the Grahani. Pathya Ahara, Bilva, and Panchakola Churna help to cure Grahani Dosha with considerable health benefits. Objectives: This study was conducted with the objectives to prepare a dietary module for the patients of Grahani and to study the clinical effect of the prescribed diet (Pathya Ahara) in Grahani. Material and Methods: A total of 60 patients of Grahani Dosha of either sex were registered. These patients were divided into two groups by random sampling method in Groups A and B. In Group A, patients were given Bilva and Panchakola Churna without any dietary modification, and patients of Group B were given a diet module to modify their diet along with Bilva and Panchakola Churna. All the patients were evaluated for subjective parameters. Results: Statistical analysis was done after the intervention of therapies for 6 weeks. Group B showed statistically significant results in all signs and symptoms as compared to Group A. Conclusion: Pathya Ahara improves the efficacy of the medicine in Grahani roga without the presence of any adverse effects.