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Introduction: Mritasanjeevana Rasa (MR) is a herbo-mineral formulation mentioned in Brihat Rasaraja Sundara, an ancient text of Rasashastra written by Dattaram Choube. MR contains Hingula (Cinnabar) as its main ingredient along with Vatsanabha (Aconitum ferox Wall ex Ser.), Jayapala (Croton tiglium L.), and Tankana (Borax). Hingula is chemically similar to Rasasindura (RS) as per modern concept (a classical preparation in Rasa Shastra) as both are red sulfides of mercury (α-HgS). Methods: MR-classical (MRC) was prepared as per textual guidelines. MR-modified (MRM) was also prepared as per the same guidelines. Hingulottha Parada was used for preparation of RS. Physicochemical characterization including ICP-MS, fourier transform-infrared spectroscopy, high-performance thin layer chromatography, thermo gravimetric analysis (TGA), and particle size analysis was performed for both samples. Results: MRC and MRM showed similar results in pH value, moisture content, ash values, water-soluble extract, hardness test, friability test, and disintegration time. ICP-MS revealed that mercury and sulfur are the main elements present in MRC and MRM. X-ray diffraction analysis confirmed the presence of sodium sulfate and mercuric sulfide (HgS) in both the samples. Both revealed scaly crystalline structures. Their average particle size was between 800 and 900 nm with the lowest particle size of 103 nm and 134 nm, respectively. FTIR analysis revealed that MRC and MRM samples contain functional groups such as C-O-C, S = O, and C-H. TGA analysis suggests that MRM showed better stability than MRC throughout the heating phase. Conclusion: The present study shows that MR and its modified formulation do not affect the Physicochemical characteristics of the final compound to a considerable extent.

Introduction: Vitiligo is nowadays a common hypopigmented skin disorder. Depending on clinical features, vitiligo can be correlated with Shwitra in Ayurveda. The present study evaluates the efficacy of the Virechana therapy to augment the effectiveness of the Bakuchi compound and Khadira Kwatha in Shwitra. Methods: The current study included thirty clinically diagnosed Shwitra patients who were randomly divided into two groups (Group A and Group B) by simple random method with 15 patients in each group. Thirteen patients in Group A and 15 patients in Group B had completed the study. The duration of the trial was 60 days. The assessment was done on the 1st, 30th, and 60th days. Results: The results revealed that intervention in Group A and B showed insignificant results in Rukshata, Daha, and Romparidhwamsi, while, respectively, significant and highly significant in Kandu. There was a highly significant result (P < 0.01 and P < 0.001 for Groups A and B, respectively) for the patches' size and the skin color. During intergroup comparison, the mean difference along with standard deviation (MSD) for size of patches in Group A was 3.76 ± 4.17 and in Group B was 14.26 ± 9.43, showing the highly significant result. Likewise, MSD for the color of skin in group A was 0.76 ± 3.77 and in Group B was 1.53 ± 6.85, showing the intergroup comparison as significant. Conclusion: “Bakuchi Compound” and “Khadira Kwatha” are safe and free from adverse effects in the management of Shwitra. The Virechana Chikitsa augments the effectiveness of this treatment.

Introduction: Tamaka Shwasa is a type of Shwasa Roga with Vata-Kapha predominance originating from Pittasthana. Tamak Shwasa can be correlated with modern entity bronchial asthma due to its similarity in signs and symptoms and causative factors. The aim of the study is to compare the efficacy of Kulattha Guda with or without Virechana Karma in the management of Tamaka Shwasa. Methods: A total of 30 patients of Tamaka Shwasa (bronchial asthma) were selected based on the signs and symptoms and randomly divided into two groups. Group A – Kulattha Guda after Virechana Karma in a dose of 10 g twice a day orally for 30 days with lukewarm water. Group B – Kulattha Guda in a dose of 10 g twice a day orally for 30 days with lukewarm water. Results: In Group A, the subjective parameters such as Shwasakricchata, Kasa, Pratishyaya, Nidralpata, Ghurghurakam, and Anxiety Control Questionnaire (ACQ) score showed percentage-wise relief as of 75.68%, 76.67%, 75%, 75%, 78.57%, and 72.20%, respectively, and in Group B, percentage-wise relief was found in Shwasakricchata, Kasa, Ghurghurakam, and in ACQ score as of 70.59%, 72.22%, 70%, and 66.92%, respectively. In Group A, objective parameters such as peak expiratory flow rate (PEFR) and forced expiratory volume 1 s (FEV1) had shown highly significant results with giving an improvement of 59.09% and 59.64%, respectively, and in Group B, percentage-wise relief was found in PEFR and FEV1 as of 54% and 52.63%, respectively. Results obtained were statistically significant. Conclusion: The trial drug was found effective and well tolerated to the patient. Kulattha Guda was administered after Virechan Karma was found more effective.

Background: Dehavada and Lohavada are the two major aims of Rasashastra. Parada Samskara is essential for both Vada. Many herbs, minerals, instruments, and preparations are needed for processing Parada. Drutis are one of such essential dosage form, along with its therapeutic and other utilities. Druti Kalpana are the processes of converting metals, gemstones and minerals in a liquefied state with the help of Agni samskar and addition of few herbal drugs, Ksharas, etc. Among many Druti Kalpana, Gandhaka Druti is a well-known preparation. Different classical texts have described different methods for preparing it. To ascertain difference between them and to come out with a brief conclusion this review work has been made. Data Source: Classical texts of Rasashastra, various published research works on the topic and valuable dissertations were also referred for this review article. Review Methods: An extensive search of literature was done to collect scattered materials on Druti Kalpana under an umbrella. Advices were taken from the professors of Rasashastra for the review of literature and their correct understanding. Result and Conclusion: Detailed review on Druti and Gandhaka Druti has been made. Comparisions on different methods of Gandhaka Druti preparation and the best method for high yield was found. Depending on the uses Variations in themethod of Gandhaka Druti preparation was found.

Background: Chronic suppurative otitis media (C.S.O.M.) is a chronic inflammation of the middle ear, which is the result of an initial episode of acute otitis media and characterized by the recurrent discharge from the middle ear through a tympanic perforation. In Ayurveda, C.S.O.M. can be correlated with Karnasrava. According to Acharya Sushruta, Karnasrava is "discharge of pus from a Vata affected ear which may result from a head injury or due to immersion in water or else due to suppuration or bursting of an abscess." In modern science, most of the approaches for the treatment of C.S.O.M. have been surgical, which are often expensive, complicated, and do not provide satisfactory hearing improvement; also these are inaccessible in many developing countries. Considering all these points, there is a need to search for an effective, preventive, and safe treatment. Objective: The objective of this study is to evaluate the efficacy of Karnapichu and Karnadhupana along with Rasnadi Guggulu on Karnasrava. Materials and Methods: A total of 30 patients with signs and symptoms of Karnasrava (C.S.O.M.) were registered and randomly divided into two groups: Group A: 15 patients were treated with Gandhaka Taila Karnapichu (8–16 drops) along with Rasnadi Guggulu orally for 30 days and Group B: 15 patients were treated with Karnadhupana locally and Rasnadi Guggulu orally for 30 days. Results: Both the groups showed highly significant results in the subjective parameters and nonsignificant results in the objective parameters of Karnasrava. Conclusion: Gandhaka Taila Karnapichu, Rasnadi Guggulu, and Karnadhupana are effective in the management of Karnasrava (C.S.O.M.).