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Start Over Descriptor "Flavones metabolism" Language hungarian
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1. [The role of drug metabolizing enzymes in the effect and side-effect of the drugs].

Author

Vereczkey L, Jemnitz K, Monostory K, Veres Z, and Kóbori L

Subjects
Animals, Cytochrome P-450 Enzyme System genetics, Drug Interactions, Enzyme Induction, Flavones metabolism, Humans, Hydrolases metabolism, Methyltransferases metabolism, Mixed Function Oxygenases metabolism, Cytochrome P-450 Enzyme System metabolism, Pharmaceutical Preparations metabolism, Polymorphism, Genetic
Abstract

The authors give an overview on the role of drug metabolizing enzymes in the effect and side-effect of drugs. They describe the properties of cytochrome P450 and other phase I enzymes (hydrolases, flavin-monooxygenases), as well as of phase II. enzymes (glucuronyl-, sulfate-, glutathione-, acetyl-, methyltranferases), their polymorphism, inductive and inhibition properties. The possible drug-drug interactions are discussed in detail.

Published
2005

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