1. [Haemolytic uremic syndrome and thrombotic thrombocytopenic purpura: classification based on molecular etiology and review of recent developments in diagnostics].
- Author
-
Prohászka Z
- Subjects
- ADAM Proteins metabolism, ADAMTS13 Protein, Analgesics, Non-Narcotic adverse effects, Antimalarials adverse effects, Complement System Proteins metabolism, Diagnosis, Differential, Hemolytic-Uremic Syndrome diagnosis, Hemolytic-Uremic Syndrome enzymology, Hemolytic-Uremic Syndrome immunology, Hemolytic-Uremic Syndrome microbiology, Humans, Neuraminidase biosynthesis, Neuraminidase metabolism, Prognosis, Purpura, Thrombotic Thrombocytopenic diagnosis, Purpura, Thrombotic Thrombocytopenic enzymology, Purpura, Thrombotic Thrombocytopenic immunology, Purpura, Thrombotic Thrombocytopenic microbiology, Quinine adverse effects, Shiga Toxins adverse effects, Streptococcus pneumoniae enzymology, Vitamin B 12 metabolism, von Willebrand Factor metabolism, Hemolytic-Uremic Syndrome classification, Hemolytic-Uremic Syndrome etiology, Purpura, Thrombotic Thrombocytopenic classification, Purpura, Thrombotic Thrombocytopenic etiology
- Abstract
Haemolytic uremic syndrome and thrombotic thrombocytopenic purpura are overlapping clinical entities based on historical classification. Recent developments in the unfolding of the pathomechanisms of these diseases resulted in the creation of a molecular etiology-based classification. Understanding of some causative relationships yielded detailed diagnostic approaches, novel therapeutic options and thorough prognostic assortment of the patients. Although haemolytic uremic syndrome and thrombotic thrombocytopenic purpura are rare diseases with poor prognosis, the precise molecular etiology-based diagnosis might properly direct the therapy of the affected patients. The current review focuses on the theoretical background and detailed description of the available diagnostic possibilities, and some practical information necessary for the interpretation of their results.
- Published
- 2008
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