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Abstract: The inflammatory process of head injury was characterised by the release of pro-inflammatory and inflammatory mediators. This process could be assessed using mediators such as platelet-lymphocyte ratio (PLR) and leukocytes. This study aims to determine the association between PLR and leukocytes in assessing the degree of head injury through the Glasgow coma scale (GCS). This study was an observational analytic study using the medical record of brain-injured patients who visited the Emergency Department of Ulin Hospital from May to November 2017. 59 samples met the criteria in this study. The results of multiple linear regression test in this study found that PLR and leucocyte affected GCS (p = 0.009). The leukocyte value was significantly more associated to GCS (p = 0.008) than PLR value (p = 0.146). The value of leukocyte R was 0.1224, and R PLR was 0.0401. Based on these results, it can be concluded that leukocytes had a better role in predicting the degree of head injury than PLR.