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This review proposes an analysis of some of the many possible psychotherapeutic treatment approaches and modalities that are most effective at present according to the latest guidelines. Psychotherapy, often underestimated, plays a key role in the integrated treatment of patients presenting with various forms of psychological distress and/or psychiatric disorders and is an essential element in the healing process. The usefulness of psychological supports is too often poorly considered in general practice clinics, while its scientific value has also been recognized by Evidence Based Medicine. This paper has set out to examine the most effective current psychotherapies for the treatment of the most prevalent psychological and psychiatric disorders at present, with a focus on the so-called third-wave or third-generation psychotherapy approaches (DBT, ST, EMDR, MBT, TMI, MBCT), which represent an evolution of standard TCC and arise precisely from the need to integrate the concreteness and Evidenced-based efficacy of TCC with the most powerful elements of the psychoanalytic approach, thus creating a unique, comprehensive and integrated synthesis. [ABSTRACT FROM AUTHOR]