1. [Advanced gastric adenocarcinoma with RER+ phenotype presents a good prognosis after 5 years of curative resection].
- Author
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de Manzoni G, di Leo A, Castelli A, Tomezzoli A, Tasselli S, Pedrazzani C, Bonfiglio M, and Scarpa A
- Subjects
- Adaptor Proteins, Vesicular Transport, Adenocarcinoma pathology, Adult, Aged, Aged, 80 and over, Chromosomes genetics, DNA, Satellite, Female, Humans, Male, Middle Aged, Neoplasm Staging, Phenotype, Prognosis, Stomach Neoplasms pathology, Time Factors, Adenocarcinoma genetics, Adenocarcinoma surgery, Membrane Glycoproteins genetics, Stomach Neoplasms genetics, Stomach Neoplasms surgery
- Abstract
Microsatellite instability (MIN) has been found both in advanced and early gastric cancer. To find out the step played by MSI in gastric carcinogenesis, links between RER+ phenotype and clinical and pathological aspects have been studied. In this work our purpose is to analyze the relationship between MIN+ advanced gastric cancer and prognosis at 5 years after radical surgery. We investigated 34 patients affected by gastric cancer who underwent R0 surgical resection from February 1991 to October 1994. After that, they underwent a four-monthly follow-up for a minimum of 5 years. Genetic abnormalities have been searched including (a) those occurring in common-type CIN carcinomas and (b) those characteristic of MIN cancers. DNA extraction showed the presence of microsatellite instability (MIN) in 9 (26%) of the samples (vs. 74% of chromosomal instability CIN); none of them was M+ (vs. 12% of CIN cancers). Recurrence occurred in 2 out of 9 of the MIN cancers (22%) and in 21 out of 25 CIN cancers (84%). In conclusion, our data suggest that advanced gastric cancers with mutator phenotype show a better outcome at 5 years than the CIN phenotype.
- Published
- 2001