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Your search keyword '"Bondavalli, F."' showing total 11 results
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11 results on '"Bondavalli, F."'

8. [1-(2-Diethylaminoethyl)-3,4-pentamethylenepyrazole and N2-substituted bornylenepyrazoles].

Author

Schenone P, Longobardi M, and Bondavalli F

Subjects
Animals, Anti-Inflammatory Agents pharmacology, Anticonvulsants pharmacology, Camphanes pharmacology, Electroconvulsive Therapy, Inflammation drug therapy, Mice, Pyrazoles pharmacology, Anti-Inflammatory Agents chemical synthesis, Anticonvulsants chemical synthesis, Camphanes chemical synthesis, Pyrazoles chemical synthesis
Abstract

An unambiguous synthesis of 1-(2-diethylaminoethyl)-3,4-pentamethylenepyrazole (III) by acid cyclization of 2-(2-cycloheptanonyl)-1,3-dioxolane 2-diethylaminoethylhydrazone, and of N2-methyl and N2-(2-diethylaminoethyl)bornylenepyrazole (VIII) and (IX), by heating the hydrazones from 3-hydroxymethylene-2-bornanone and methylhydrazine or 2-diethylaminoethylhydrazine respectively, is described. (III) showed antiinflammatory activity and (VIII) an anticonvulsant action.

Published
1975

9. [Derivatives of 5-hydroxymethylen-cis-4-caranone].

Author

Bondavalli F, Schenone P, and Longobardi M

Subjects
Animals, Bridged-Ring Compounds, Central Nervous System drug effects, Drug Evaluation, Preclinical, Hydrogenation, Indazoles pharmacology, Oxazoles pharmacology, Spectrophotometry, Infrared, Indazoles chemical synthesis, Oxazoles chemical synthesis, Pyrazoles chemical synthesis
Published
1974

10. [New camphidine derivatives].

Author

Longobardi M, Schenone P, and Bondavalli F

Subjects
Alkynes chemical synthesis, Aza Compounds chemical synthesis, Propylamines chemical synthesis, Spectrophotometry, Infrared, Anti-Inflammatory Agents chemical synthesis, Antihypertensive Agents chemical synthesis, Antiparkinson Agents chemical synthesis, Camphanes chemical synthesis, Narcotic Antagonists
Published
1974

11. [N 1-nicotinoyl and isonicotinoylpyrazoles].

Author

Bondavalli F, Longobardi M, and Schenone P

Subjects
Animals, Anticonvulsants chemical synthesis, Central Nervous System drug effects, Indicators and Reagents, Isonicotinic Acids chemical synthesis, Isonicotinic Acids pharmacology, Magnetic Resonance Spectroscopy, Mice, Muscle Relaxants, Central chemical synthesis, Nicotinic Acids pharmacology, Pyrazoles pharmacology, Nicotinic Acids chemical synthesis, Pyrazoles chemical synthesis
Abstract

Synthesis of twelve N 1-nicotinoyl and isonicotinoylpyrazoles by reaction of 4,5-tetra-, penta-, hexamethylenepyrazoles, dihydronaphtopyrazole, bornylenepyrazole and cineolylenepyrazole with nicotinoyl and isonicotinoylchloride, is described. The structure of N 1-derivatives of these compounds was ascertained by comparison of N.M.R. spectra with those of 1-nicotinoyl and 1-isonicotinoyl-4,5-pentamethylene-5-hydroxy-2-pyrazoline, obtained by reaction of 2-hydroxymethylenecycloheptanone with nicotinoyl and isonicotinoylhydrazide, respectively. N 1-isonicotinoylbornylenepyrazole shows weak C.N.S. depression, muscle relaxation and anticonvulsant activity.

Published
1975

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