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Aim: The authors signal a case of gastric polypoid signet ring cell carcinoma, of particular interest for its rarity like show from the review of the literature, which is the first to have been described after Tabaru's citation., Methods: The study has been carried out at the Department of Surgical and Oncological Sciences of the University of Palermo. It has been based on 2000 cases analysed from June 2001 to December 2003., Results: The authors advance some and emphasizes the diagnostic flow chart and therapeutic choices adopted., Conclusions: We agree that the endoscopic polypectomy is surgical procedure of first approach, but modifying the therapeutic guideline in relation to histologic examination, like happened in the case in issue.

An occasional finding of a signet-ring cell type adenoma, occurring in a 81-year-old man, suffering from inoperable pharyngo-laryngeal carcinoma, is described. Multinodular thyroid parenchyma was excided in performing tracheostomy and histologically examined. On the basis of extensive morphological, histochemical and immunohistochemical observations and of reviewed literature, an unifying morphogenetic interpretation of the signet-ring cell transformation is proposed, with special reference to the pathogenesis of this cytotype and the significance of the cytostructural and cytometabolic characteristics. Problems related to the differential diagnosis and clinicopathological correlation are also discussed.

The paper reports a case of intestinal occlusion due to adenocarcinoma of the large intestine as a sequel to ureterosigmoidostomy for exstrophy of the bladder which was subsequently converted to ureteroileocutaneostomy. Inadequate follow-up did not allow an early diagnosis to be made. The authors underline the need for annual colonoscopy in all patients suffering from or with previous ureterosigmoidostomy given the high incidence of malignant transformation of the colon.