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The authors describe the encouraging results obtained in the treatment of uterine myomas during pregnancy, using vitamin E at a dose of 300 mg times a day, starting the administration from the time of the first examination of the patient, which took place between week 6 and 12 of gestation. A group of 25 women underwent treatment, aged between 25 and 41 years old, of whom 15 were primigravidas and 10 with one or more previous pregnancies, suffering from uterine myomas in pregnancy, and observed between 1986 and 1994. All the pregnancies continued to term and elective cesarean section was performed associated with single or multiple myomectomy. The neonatal outcome was satisfactory in all cases and no collateral effects were observed in either mothers or fetuses.

The authors, after a short review of the literature, report a clinical case observed by them. They describe a case of unsuspected uterine leiomyosarcoma diagnosed after a miomectomy and they discuss the question about therapeutic management.