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Objective: Aim of the study was to investigate the psychometric properties of the Italian version of the Drug Attitude Inventory (DAI) by exploring its construct validity., Setting: 90 voluntary admitted patients with DSM III-R Schizophrenic (n.72) and Schizoaffective (n.18) disorders, age range between 18 and 50 years, treated with typical antipsychotics, able to participate in the study, were selected., Design: Exploratory factor analyses with alpha factoring and maximum-likelihood methods with Varimax Rotation were used to analyse DAI scores., Results: Extraction methods found 7 factors which explained 62.5% of the total variance. The first 2 factors could be labelled as "subjective response to treatment" construct and factors 3 to 7 as "attitude to medication" construct., Conclusion: Although preliminarily, the Italian version of the DAI seems to maintain the original psychometric properties and it can be used easily to get a valid measurement of the patients' attitude to neuroleptic medication.