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The dithienyldisulfides (II a-e) were prepared by condensation of dipotassium nitroethylendithiolate and alpha-chlorocarbonyl derivatives, followed by oxidation with iodine. The N.M.R., I.R. and M.S. spectral behaviour is discussed. The activity against the leukemia P388 tumor system in mice was tested.

A series of bis-amides of 2,2'-dicarboxydiphenyldisulfides with monosubstituted N-alkyl groups (substances I leads to XXVI) or N-aralkyl groups (substances XXVI leads to XLII) was prepared and examined for in vitro antifungal activity. The substances were obtained by condensing the chloride of 2,2'-dicarboxydiphenyldisulfide with suitable amines. The fungistatic activity of the products was tested in vitro against the following four strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, Trichophyton mentagrophytes. The results obtained summarised in Tables I and II amplify the structure-antifungal activity relationships of this class of compound. The most active compounds proved to be bis-(N-n.heptyl-2-carboxami-dophenyl)disulfide (XX) and bis-(N-beta-4Cl-phenylethyl-2-carboxamidophenyl)disulfide (XXXV).

The synthesis of 2,2'-dithienyldisulfides, variously substituted in position 3 and/or 5 with --NO2, --NHCOCH3, --SO2NH2 groups and of 2,2'-dinitro-3,3'-dithienyldisulfide is described. The antitumor activity of these compounds was tested.

In continuation of previus research on the antimitotic activity of aryldisulfides, the Authors have synthesised 3- and 5-chloro or fluoro substituted bis-(2-aminophenyl)disulfides and some of their 2-N-alkyl derivatives. These compounds were synthesised in order to submit them to biological testing to find any activity caused by halogen substituents on the benzene ring.