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Unlabelled: We had intended to reckon quantitatively the effects of volatile anaesthetics(Halothane, Ethrane, methoxyflurane or Penthrane) upon cardiovascular system of healthy young mongrel dogs, 5-8 days interval each other. After administration of a Halothane and Penthrane, heart rate(HR) increases of about 30%; blood pressure(BP) is decreasing of same percentage. Halothane causes a slight increase upon pulmonary arterial pressure(PAP), while pulmonary arterial flow(PAF) reaches 40% more than control values. Penthrane decreases of 30% PAP and of about 40% PAF. Ethranic anaesthesia produces a slight fall on HR and BP, while PAP doesn't result significatively modified; a marked decrease(40%) is observed on PAF. Aortic flow(AF) is diminished(from 20 to 30%) by administration of these anaesthetics., In Conclusion: Halothane causes very significative modifications on circulation, less modifications are produced by Penthrane, while Ethrane doesn't produce any changes.

We had intended to reckon quantitatively the effects of volatile anaesthetics about myocardial contractility and coronary circulation, on rest and after total occlusion of the left circumflex coronary artery for 15 sec on young healthy mongrel dogs. Halothane decreases coronary flow of about 20% while Penthrane increase coronary flow (CF) of 30% after 20 sec and later it stabilizes to 10% higher than the control values. Ethrane causes a light initial decrease and later CF returns to control values. During occlusion, derivative of left ventricular pressure (LVP) is reduced from Halothane, which also causes a marked decrement of hyperemia. By means of penthranic anaesthesia, during occlusive phase, we observed a shortening in contraction and relaxation speed. Ethrane doesn't modify the hyperemic coronary flow nor cardiodynamic parameters during occlusive period, while the latter parameters are sensibly varying during restore.

Intraocular pressure and arterial blood pressure were studied in 27 patients undergoing anaesthesia induced by 0,6-1 mg/kg of Althesin iv and maintained by methoxyflurane-N2O-O2 on spontaneous ventilation. All patients were scheduled to undergo various types of eye surgery, including open-eye surgery. Patients with glaucoma and cataract were administered 20% mannitol two hours prior to surgery. In all cases premedication was based on meperidine, promethazine and atropine sulphate im. During the entire period of anaesthesia the intraocular pressure and, generally, arterial blood pressure appeared to be lowered.

An in vitro analysis was conducted to investigate the hypothetical antibacterial and antimycotic activity of the common anesthetic gases (halothane, enflurane, isoflurane, methoxyflurane) in view of the clinical absence of bronchopulmonary pathology after inhalation narcosis despite the many risk factors involved. For this purpose scalar dilutions of the four gases were prepared on cultures of Klebsiella pneumoniae and Candida albicans and the antibacterial action of the gases was tested in vitro. Even with the weaker concentrations used, halothane and methoxyflurane totally inhibited both microorganisms. Enflurane had less effect on Klebsiella p. and almost none on Candida. Isoflurane, a new halogen ether anesthetic was found to have an excellent inhibitory effect. In conclusion it is hypothesised that the anesthetic gases considered might have an in vivo antibacterial activity considering the experimental results obtained in vitro.