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Aim: The purpose of this retrospective review of the charts of 51 Jehovah's Witness patients, who underwent surgery without blood transfusions, was to compare two study groups (major surgery vs minor-medium surgery)., Methods: We compared the following variables: age, sex, length of stay, type of surgical operation, use of intraoperative red cell salvaging devices, hemodilution, number of drainages and their stay, postoperative blood loss, complications, need of reoperation and mortality rate. Between medical variables we focused on blood production therapy and nutritional support (administration of iron, folate, erythropoietin and albumin) and blood tests (at the first day of admission; intraoperative; at the first postoperative day; at the discharge)., Results: In the two study groups, we detected statistically significant differences in the following variables: total of postoperative blood loss (p < 0.00001), complications rate (p = 0.0122) and in Hgb values (intraoperative: p = 0.0197; at the first postoperative day: p = 0.0028; at the discharge: p = 0.0100)., Discussion: The aims of a bloodless surgery program are: 1) minimize blood loss, reducing iatrogenic anemia and intraoperative hemorrhage loss; 2) maximize blood production by administration of erythropoietin, iron and folate; 3) maximize cardiac output by alternatives to blood transfusions, as crystalloids, colloids and blood substitutes; 4) increase oxygen content; 5) decrease metabolic rate. We focused on advantages and disadvantages of the suggested procedures. Most interesting techniques are the normovolemic hemodilution and the intraoperative red cell salvaging devices, indispensable in emergency., Conclusions: A close team-work between surgeons, anesthesiologists and hematologists is determinant in a reference center that guarantees experience, organization, professionality, respect for the patients' will and, above all, low morbidity and mortality rates, as those reported by our series.

Surgical treatment in patients with heavy coagulation disorders needs measures that minimize immediate and post-surgical hemorrhagic risk. Besides the subjects afflicted with constitutional coagulation pathologies such as haemophilia A, B, C, AB, Von Willebrand disease, platelet disorders and others, too many are the patients that need pharmacological therapy to impede the creation of intra-vascular coagula. Today, surgical treatment of these patients is possible with the use of human fibrin glue (Tissucol) that permits excellent surgical and post-surgical hemostasis without therapy suspension, independently of coagulation disorder. The purpose of this study is a clinical evaluation of a surgical procedure based on the use of human fibrin glue in association or not with suture, hemostatic sponge and lyophilized dura mater in patients with coagulation disorders. In a group of 309 patients in oral anticoagulant therapy have been done a total of 822 operations such as root fragments extraction with mucoperiosteal flap elevation, teeth or roots simple extractions, third molar extractions, cyst removal, apicoectomies. Only patients with PA over 20% have been treated. All the operations have been leaded with minimal trauma; after the extractions, alveolar margins have been regularized to improve flaps adaptation. Hemostatic sponge or dura mater have been used like basis for the flaps and the fibrin glue, that was injected in the residual cavity after surgical suture. In a few cases, for example with little extraction wounds, only fibrin flue without suture or sponge has been used. In all cases and after all operations, the presence or absence of bleeding has been evaluated after 2 hours, 24 hours, 7 days after surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

The study, conducted on 40 patients with pain resulting from "minor" general surgery, for the purpose of evaluating the efficacy and tolerability of ST-679 (administered in a single oral dose of 1200 mg in 20 patients) and to compare them with those of paracetamol (administered in a single oral dose of 1000 mg in 20 patients), demonstrated that the new drug was active on all recorded parameters and superior to the reference drug. The evaluation of the evolution of pain, performed using the Scott-Huskisson visual analog scale, evidenced that the maximum analgesic efficacy of ST-679 is reached after 1 hour and 15 minutes from assumption and remains unaltered until the final observation (6 hours). The paracetamol registers maximum analgesic efficacy after 30 minutes, but does not remain constant for the entire observation period. All the other parameters evaluated (variation in pain intensity, peak of analgesic activity and total remission of pain) are significantly favorable to ST-679. The tolerability of ST-679 was very good and better than the reference drug.

In 67 patients submitted to surgical procedures serum neopterin (NPT) and Interleukin 2 soluble receptors (IL2R) were evaluated at the end of the operation as well as 24, 48, 72 hours later. Thirty seven of the subjects (Group B) had undergone minor surgery (average time of operation: 40 +/- 10 min.), thirty (Group A) had undergone major surgery (average time: 180 +/- 30 min.). The results showed elevated NPT and IL2R levels in the latter cases and, in particular, 48 and 72 h after surgery. Neopterin levels were positively correlated with IL2R (r = 0.548 p < 0.01). These data suggest an activation of the cellular immune response which parallels the magnitude and length of surgical trauma. Thus NPT and IL2R levels could represent biochemical markers of postoperative disorders of the immune homeostasis.

Different drug combinations were compared in order to assess the quality of anesthesiological control, tolerability and the speed of reawakening and recovery of self-sufficiency in 60 patients undergoing minor surgery. Propofol, combined with fentanyl and N2O due to its inadequate analgesic cover, showed a quickness of action with scarse side-effects, prompt reawakening and rapid recovery of deambulatory self-sufficiency in comparison to the associations of thiopentonefentanyl and thiopentone-isoflurane, thus indicating its preferential use in short surgical operations which can be carried out under a day hospital regimen. In addition, some medico-legal aspects of dimissional of recent developments regarding professional responsibility.

Ninety patients were included in a study to assess the clinical characteristics of vecuronium bromide used in children. The myorelaxant was administered to all patients using different routes. The use of vecuronium at a dose approximately equal to 1ED95 was characterised by a duration of action sufficient to allow its use in short operations; on the other hand, it also produced a long induction-intubation interval and not optimal conditions in which to perform intubation. Conditions for intubation improved during induction via inhalation and there was a reduced induction-intubation interval compared to intravenous induction using the same dose of vecuronium. A further reduction in intubation time was obtained by increasing the dose from 50 to 150 micrograms/kg-1 together with an increased clinical duration of action. The "priming principle" technique also allowed intubation time to be shortened without variations in the duration of action provided a full dose of vecuronium, 100 micrograms/kg-1, was used. However, this was also associated with a notable incidence of adverse reactions. Of the various combinations examined, the most advantageous association of pre-dose and interval between doses was the association of a pre-dose of 10 micrograms/kg-1 and an interval of 4 min between doses. Lower doses countered the advantages of priming, whereas higher doses resulted in an increased number of adverse reactions without producing notable changes in the intubation time.

We studied 96 patients undergoing short gynecological procedures. Anaesthesia has been induced with fentanyl 1.5 micrograms/kg (45 patients) or alfentanil micrograms /kg (51 patients) and a hypnotic dose of propofol, and maintained with 70% N2O via facial mask. We observed a better and more rapid control of surgical analgesia with alfentanil, and an earlier recovery of postoperative psychophysical functions. Post-induction apnea has been more frequent and prolonged in the alfentanil group, but no difference in the time necessary to recover an adequate ventilation has been observed between the two groups. Alfentanil anaesthesia determined a more marked intraoperative bradycardia. By virtue of the speed of onset and the short duration of action, alfentanil is a suitable anaesthetic agent for short surgical procedures, particularly in day-stay patients.

In order to evaluate the validity of a new method for measuring the whole body mineral content in diagnosing senile osteoporosis we studied 3 groups of male subjects: the first one composed by 40 young healthy subjects (mean age 24.7 years), the second composed by 40 normal patients (mean age 51.3 years); the 3rd group consisted of 26 elderly patients affected with typical osteoporotic fractures (mean age 77 years). All of them underwent a measurement of the spine as well as whole body mineral content performed with a dual photon absorptiometer. The measurements showed a decreasing in mineral content in the second versus the first group but a high correlation coefficient between spine and WB measurements characterized both groups; a striking decrease of it (r = 0.22) was found in the 3rd group. The relative unreliability of the spine measurement in elderly is probably due to the age-linked anatomical alteration. We therefore conclude that WB measurement must be considered the method of choice for the detection of senile osteoporosis.

Psychodiagnostic tests have been used in a study on patients undergoing general anaesthesia for minor surgery, the purpose being to evaluate patient recovery and autonomy prior to discharge. The patients considered were submitted prior to operation to the Peg board test, tre Trieger test and the Writing test to obtain standard reference values. These tests were repeated every 10-15 minutes from the end of operation as soon as patients recovered consciousness and were able to cooperate. The comparative study showed that patients who had been anesthetized with Ethrane recovered more rapidly, followed by those treated with Fluothane, Propanidide and Althesin.

The widespread use of local anesthetic agents in connection with minor office and emergency surgery prompted the authors to look into various aspects of this practice. Doubtless, these drugs are extremely handy and constitute a valuable aid in many situations; still, possible complications and contraindications must be clearly assessed. The authors conclude their discussion with an outline of essential things to do in the event of unexpected clinical mishaps.

As part of an investigation of the quality of the return to consciousness after anaesthesia, a comparison was made between recovery times in 60 patients divided into three groups, subjected to general anaesthesia and shallow maintenance with halothane, mixed short shallow neuro-analgesia, and short analgesia anaesthesia. Psycho-aptitudinal recovery was evaluated with three graphic tests. The results indicate that recovery times are much shorter for shallow neuro-analgesia, and particularly for analgesic anaesthesia by comparison with ordinary shallow techniques coupled with maintenance in O2 + N2O + Halothane.

A brief general survey of the "anaesthesiological problem" is followed by the presentation of a method for use in ultra-short anaesthesia. Particular stress is laid on the importance that must be ascribed to premedication, even in situations of this type. The drug of choice is trazodone. An account is given of the main features of this synthetic molecule, and the details of its administration are described. Reference is also made to a series of 792 minor obstetric and gynaecological operations in which the method was employed. The size and range of this series are regarded as an outstanding aspect of the paper.

Personal experience in minor surgery with Althesin alone (200 cases) and in association with hydroxyzine in the same syringe (250 cases) is reported. Comparison showed that the association is useful, particularly in cases where the operation lasts longer and involves greater pain stimuli. It is felt that the method described will extend the use of Althesin in minor surgery.