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Competing Interests: Conflict of interest: RC and PT are employes of Intexo Società Benefit. DP and PN have no conflict of interest to declare.

Improving health around the world is an important social objective, which provides direct payoffs in terms of longer and better lives. There is also a large consensus that improving health can have equally large indirect payoffs through accelerating economic development. The role that health conditions play in affecting growth is mainly analyzed via two channels: the direct labour productivity effect and the indirect incentive effect. The labour productivity hypothesis asserts that individuals who are healthier have higher returns to labour input. This is well tested in the empirical literature with mixed conclusions. The incentive effect is borne of the theoretical literature, and individuals who are healthier and have a greater life expectancy will have the incentive to invest in education as the time horizon over which returns can be earned is extended. Education is the driver of economic growth, and thus health plays an indirect role. Other minor channels have developed in the literature through which health affect economic development. However, although cross-country empirical works show a strong correlation between measures of health (for example, life expectancy) and economic growth, a causal effect of health and disease on economic development has not been established in the literature. A recent study challenges the view that different health conditions explain cross-country income differences. This study suggests that an improvement in mortality rate due to more effective public health measures and the introduction of new chemicals and drugs starting in the 1940s determines an increase in the population size which in turn reduces income per capita and economic growth.

Pathogenesis of febrile convulsions (FC) is still unknown, suggested causes include the role of antidiuretic hormone (ADH). ADH is an endogenous antypyretic and his excessive production of the consequent hyponatraemia may be the cause of FC in children with susceptibility to this type of seizure. Whereas, interleukin-1 (IL1) is a pyrogenic substances and is involved in the release of AVP. Helminen et al. have reported a significantly higher production of IL1 in culture of peripheral blood monocytes stimulated with lipopolysaccharide (LPS) of children with FC than in the others with fever but without convulsions. More recently Lahat et al. have compared plasma and cerebrospinal fluid ILI levels of children with FC with those of children with fever but without convulsions, but they did not find significant differences. The aims of this study were to determine the IL1 levels in vivo and in the supernatants of cultures of peripheral blood mononuclear cells (PBMC) stimulated or not with LPS in children with FC and in children with fever without FC and to evaluate the influence of ADH and diazepam (DZ) on IL1 production. Blood samples for PBMC cultures were obtained from 11 children with FC on the hospital admission, (group 1) and after 48 hours from treatment with DZ (group 2). The production of IL1 was measured by RIA in the supernatants of the PBMC stimulated with LPS, LPS + DDAVP (synthetic vasopressin), LPS + DZ and in vivo in plasma samples. The control groups were constituted by 9 children with fever and without convulsions (group 3), 4 of them were studied at the end of fever too (group 4), and finally by 9 children in good health (group 5). No significant differences were observed. These results do not support the hypothesis that increased production of IL1 is involved in the pathogenesis of FC in children.