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4. [The use of erythropoietin alpha in programs of high-dose chemotherapy].

Author

Danova M, Aglietta M, Pierelli L, Ferrari S, Perillo A, Scambia G, and Henry D

Subjects
Anemia chemically induced, Antineoplastic Agents administration & dosage, Blood Transfusion, Drug Administration Schedule, Epoetin Alfa, Erythropoietin blood, Granulocyte Colony-Stimulating Factor therapeutic use, Granulocyte-Macrophage Colony-Stimulating Factor therapeutic use, Hematopoietic Stem Cell Mobilization methods, Hematopoietic Stem Cells drug effects, Humans, Recombinant Proteins, Anemia therapy, Antineoplastic Agents adverse effects, Bone Marrow drug effects, Erythropoietin therapeutic use, Hemoglobin A metabolism
Abstract

Epoetin (Epo) is physiologically present in the human body, stimulating erythropoiesis from bone marrow. Anemia is observed in cancer patients submitted to high-dose chemotherapy (HDCT), mainly caused by myelosuppression. Epoetin alfa has been widely used to treat the anemia that develops in the HDCT setting. Controlled studies in patients with hematologic malignancies or solid tumors who received Epo following HDCT have shown a decreased red blood cell transfusion requirement at least in patients receiving allogeneic bone marrow transplantation (BMT), while results in patients receiving autologous BMT have been disappointing. The administration of Epo before HDCT, in a period when bone marrow is still responsive to growth factors, may represent a new strategy aimed at decreasing the degree of anemia in these patients. A combination of granulocyte-colony stimulating factor and Epo has proved to be effective in mobilizing stem cell and committed myeloid/erythroid precursors.

Published
2000

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