1. [A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs].
- Author
-
Pasero G and Marson P
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal pharmacology, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Antirheumatic Agents pharmacology, Antirheumatic Agents therapeutic use, Biochemistry history, Cyclooxygenase Inhibitors history, Cyclooxygenase Inhibitors pharmacology, Cyclooxygenase Inhibitors therapeutic use, Dinoprostone biosynthesis, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Inflammation drug therapy, Inflammation metabolism, Pain drug therapy, Prostaglandin Antagonists history, Prostaglandin Antagonists pharmacology, Prostaglandin Antagonists therapeutic use, Anti-Inflammatory Agents, Non-Steroidal history, Antirheumatic Agents history
- Abstract
The chemical advances of the 20th century led to the synthesis of non steroidal anti-inflammatory drugs (NSAIDs), beginning from phenylbutazone and indomethacin and continuing with other new drugs, including ibuprofen, diclofenac, naproxen, piroxicam and, more recently, the highly selective COX-2 inhibitors (coxibs). This progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane.
- Published
- 2010
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