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A modified version of the contact test was used to assess the activity of a 1.2% and a 2.4% aqueous solution of formaldehyde against 14 hospital and standard bacterial strains. Generally speaking, there was average antibacterial activity for contact times in the 15-30 min range, while excellent activity was observed when longer periods were employed.

The Authors have compared the antibacterial activity "in vitro" of new cephalosporines (cephuroxim, cephoxitin and cephaclor) with other cephalosporines having an action which is already known (cephaloridine, cephazoline and cephalexine) on the Gram-negative bacterial strains of recent clinical isolation. The results show that the cephalosporines of last generation, having in their molecular nucleus a methoximinic group, realize a greater antibacterial protection than those cephalosporines of antecedent preparation.

The activity in vitro of the dibekacin was compared with that of piperacillin, cefotaxime and cefuroxime against 266 recently isolated gramnegative pathogens. Dibekacin was consistently more potent than cefotaxime, cefuroxime and piperacillin, with MIC50 and MIC90 values lower than the others. Dibekacin and cefotaxime were essentially similar in activity against all the bacteria, with the singular exception of Pseudomonas aeruginosa, which was markedly more susceptible to the former drug.