Search

Your search keyword '"Thyroid Nodule genetics"' showing total 2 results
Start Over Descriptor "Thyroid Nodule genetics" Language italian
2 results on '"Thyroid Nodule genetics"'

1. [Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates].

Author

Guerra A, Carrano M, Angrisani E, and Vitale M

Subjects
Adenocarcinoma, Follicular chemistry, Adenocarcinoma, Follicular genetics, Adenocarcinoma, Follicular pathology, Adenocarcinoma, Follicular surgery, Carcinoma, Papillary chemistry, Carcinoma, Papillary genetics, Carcinoma, Papillary pathology, Carcinoma, Papillary surgery, DNA, Neoplasm genetics, Diagnosis, Differential, Humans, Retrospective Studies, Sensitivity and Specificity, Thyroid Diseases diagnosis, Thyroid Diseases genetics, Thyroid Diseases pathology, Thyroid Diseases surgery, Thyroid Neoplasms chemistry, Thyroid Neoplasms genetics, Thyroid Neoplasms pathology, Thyroid Neoplasms surgery, Thyroid Nodule chemistry, Thyroid Nodule genetics, Thyroid Nodule surgery, Thyroidectomy, Adenocarcinoma, Follicular diagnosis, Biomarkers, Tumor analysis, Biopsy, Fine-Needle, Carcinoma, Papillary diagnosis, Mutation, Missense, Oncogene Proteins, Fusion genetics, Oncogenes, Point Mutation, Protein-Tyrosine Kinases genetics, Proto-Oncogene Proteins B-raf genetics, Thyroid Neoplasms diagnosis, Thyroid Nodule pathology
Abstract

Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.

Published
2013
Full Text
View/download PDF

2. [Association of sporadic limb-girdle muscular dystrophy and autonomous thyroid nodule in 3 Germans].

Author

Di Lorenzo L, Lupoli G, Cosentini E, Rippa PG, and Lombardi G

Subjects
Adult, Autoantibodies blood, Electromyography, Female, Germany ethnology, HLA Antigens genetics, Haplotypes, Humans, Incidence, Male, Muscle Proteins analysis, Muscles enzymology, Muscular Dystrophies classification, Muscular Dystrophies genetics, Thyroid Hormones blood, Thyroid Nodule blood, Thyroid Nodule epidemiology, Thyroid Nodule genetics, Thyrotropin-Releasing Hormone, Muscular Dystrophies complications, Thyroid Nodule complications
Abstract

The paper reports an association of limb-girdle muscular dystrophy and autonomous functioning thyroid nodule in two brothers and in one sister, a healthy carrier of this muscular dystrophy and with analogous thyroid pathology. It is interesting to outline the rarity of this association and the affinity of the clinical and electromyography pictures in thyrotoxic myopathy and in muscular dystrophy. In this three patients were studied: the muscular enzymes, electromyography and biopsy, HLA typing, thyroid scanning, thyroid hormone levels and TGA and TMA antibodies. However, the peculiarity of this case report may suggest the influence of genetic factors; moreover the existence of possible linkage between HLA system and association of two pathologies must be excluded, taking in account that the results of HLA types in these three Germans indicate different haplotypes.

Published
1991

Catalog

Books, media, physical & digital resources
See catalog results