1. [Steroid-Dependent Nephrotic Syndrome Due to Minimal Change Glomerulonephritis Treated with Rituximab].
- Author
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Cristiano F, Verratti V, Di Matteo G, Fulle S, Cristiano J, D'Angelo B, Caravelli L, Posari C, Schiazza A, and Piano A
- Subjects
- Female, Humans, Rituximab adverse effects, Antibodies, Monoclonal, Murine-Derived therapeutic use, Immunosuppressive Agents adverse effects, Steroids, Recurrence, Treatment Outcome, Nephrotic Syndrome complications, Nephrotic Syndrome drug therapy, Nephrosis, Lipoid complications, Nephrosis, Lipoid drug therapy
- Abstract
47-year-old woman suffering from minimal lesion glomerulonephritis previously undergone high-dose steroid therapy and subjected to exacerbations of nephrotic syndrome after therapy discontinuation. It was decided to initiate off-label treatment with Rituximab at a dosage of 375 mg/m2 administred at zero-time, one-month and three months with good therapeutic response and resolution of the clinical laboratory picture. The therapy was well tolerated and had no side effects. This scheme could be an alternative to the conventional therapeutic scheme with steroids or other classes of immunosuppressive drugs, especially in order to avoid problems related to prolonged exposure to steroid therapy., (Copyright by Società Italiana di Nefrologia SIN, Rome,Italy.)
- Published
- 2024