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Your search keyword '"Endothelins chemistry"' showing total 11 results
Start Over Descriptor "Endothelins chemistry" Language japanese
11 results on '"Endothelins chemistry"'

1. Current progress in therapeutic agents for pulmonary arterial hypertension: new insights into their mechanisms of action from endothelin system.

Author

Horinouchi T, Mazaki Y, Terada K, Higashi T, and Miwa S

Subjects
Endothelins chemistry, Epoprostenol metabolism, Humans, Nitric Oxide metabolism, Receptors, Endothelin chemistry, Receptors, Endothelin metabolism, Signal Transduction, Endothelins metabolism, Hypertension, Pulmonary drug therapy, Hypertension, Pulmonary metabolism
Published
2016
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2. [Gene, molecular structure, and biosynthesis of the endothelin system].

Author

Emoto N

Subjects
Animals, Cardiovascular Abnormalities etiology, Craniofacial Abnormalities etiology, Endothelin-Converting Enzymes, Gene Deletion, Humans, Metalloendopeptidases, Mice, Mice, Knockout, Aspartic Acid Endopeptidases deficiency, Aspartic Acid Endopeptidases genetics, Aspartic Acid Endopeptidases physiology, Endothelins biosynthesis, Endothelins chemistry, Endothelins genetics, Endothelins isolation & purification
Published
2004

3. [Discovery of endothelin and its significance].

Author

Goto K

Subjects
Amino Acid Sequence, Animals, Azepines, Drug Design, Endothelin Receptor Antagonists, Endothelin-1 pharmacokinetics, Endothelin-1 pharmacology, Endothelin-1 physiology, Humans, Indans, Indoles, Molecular Sequence Data, Peptides, Cyclic, Pyrimidines, Receptors, Endothelin physiology, Sulfonamides, Vasoconstriction drug effects, Cardiovascular Diseases etiology, Endothelins biosynthesis, Endothelins chemistry, Endothelins physiology
Published
2004

4. [Endothelium-derived vasoactive factors and atherosclerosis].

Author

Hirata Y

Subjects
Animals, Carrier Proteins physiology, Endothelin-1 physiology, Endothelins chemistry, Humans, Mice, Nitric Oxide chemistry, Nitric Oxide physiology, Ubiquitin-Protein Ligases, Aging metabolism, Arteriosclerosis metabolism, Endothelins physiology
Published
2002

5. [Hypertension and endothelin].

Author

Kurihara H and Yazaki Y

Subjects
Animals, Humans, Mice, Peptides, Cyclic therapeutic use, Vasoconstriction, Endothelins chemistry, Endothelins physiology, Hypertension drug therapy, Hypertension etiology
Published
1995

6. [Agonists and antagonists to endothelin receptors].

Author

Ihara M and Yano M

Subjects
Amino Acid Sequence, Animals, Endothelins chemistry, Endothelins physiology, Hypertension, Ischemic Attack, Transient, Molecular Sequence Data, Peptides, Cyclic isolation & purification, Peptides, Cyclic pharmacology, Receptors, Endothelin chemistry, Receptors, Endothelin classification, Streptomyces metabolism, Vasoconstriction, Endothelin Receptor Antagonists, Endothelins pharmacology
Published
1993

7. [Molecular biology of endothelins and endothelin receptors].

Author

Arai H, Hosoda K, Shirakami G, Yoshimasa T, and Nakao K

Subjects
Amino Acid Sequence, Animals, Endothelins genetics, Humans, Molecular Sequence Data, Receptors, Endothelin genetics, Endothelins chemistry, Receptors, Endothelin chemistry
Abstract

Endothelin (ET) was initially identified as a potent vasoconstrictor peptide with 21 amino-acid residues, produced by cultured porcine aortic endothelial cells. Cloning of the ET genes revealed the existence of three isopeptides, ET-1, ET-2 and ET-3, which are widely distributed in a variety of tissues and possess wide variety of pharmacological functions. Recently, two subtypes of ET receptor have been isolated by the expression cloning technique and the molecular characteristics of the receptors were elucidated. Subsequently, the structural organizations of the ET receptor genes have been investigated. This article discusses the structure, function and expression of ET ligands and receptors from the molecular biological aspect.

Published
1993

8. [Physiological and pathophysiological role of endothelin-endothelin receptors system in cardiovascular system].

Author

Hirata Y

Subjects
Amino Acid Sequence, Animals, Cardiovascular Physiological Phenomena, Humans, Molecular Sequence Data, Endothelins chemistry, Receptors, Endothelin chemistry
Abstract

Since the discovery of a potent endothelium-derived vasoconstrictor peptide, termed endothelin (ET) in 1988, recent studies using molecular biology technique have revealed the existence of ET isopeptides (ET-1, ET-2, ET-3) and receptor subtypes (ETA, ETB). In cardiovascular system, ET family plays important roles not only in regulation of vascular tonus as a vasoconstrictor, but also in cardiovascular remodeling as a growth factor. Development and application of antagonists selective for ETA and ETB receptor and inhibitor of ET-converting enzyme should elucidate pathophysiological roles of ET family and its receptors in cardiovascular diseases.

Published
1993

9. [Endothelin receptors].

Author

Hirose S and Hagiwara H

Subjects
Animals, Cloning, Molecular, DNA, Molecular Structure, Muscle Contraction, Endothelins chemistry, Receptors, Endothelin chemistry, Receptors, Endothelin genetics, Receptors, Endothelin isolation & purification
Published
1992

10. [The role of endothelins in pulmonary circulation and gas-exchange].

Author

Ichikawa K and Amaha K

Subjects
Amino Acid Sequence, Animals, Asthma etiology, Asthma metabolism, Endothelins chemistry, Humans, Molecular Sequence Data, Muscle Contraction, Muscle, Smooth physiology, Muscle, Smooth, Vascular physiology, Pulmonary Artery physiology, Respiratory Distress Syndrome etiology, Respiratory Distress Syndrome metabolism, Endothelins physiology, Pulmonary Circulation, Pulmonary Gas Exchange
Published
1992

11. [Bioactive peptide with cell growth-stimulating activity].

Author

Yamaguchi K, Kusuhara M, and Suzaki A

Subjects
Amino Acid Sequence, Animals, Blood Pressure, Cell Division, Endothelins chemistry, Molecular Sequence Data, Muscle, Smooth, Vascular metabolism, Receptors, Cell Surface metabolism, Receptors, Endothelin, Signal Transduction, Vasoconstriction, Endothelins physiology
Published
1991

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