1. [Bone diseases caused by impaired glucose and lipid metabolism].
- Author
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Kanazawa I and Sugimoto T
- Subjects
- Animals, Bone Diseases metabolism, Bone Diseases pathology, Bone and Bones metabolism, Bone and Bones pathology, Collagen metabolism, Glycation End Products, Advanced adverse effects, Humans, Life Style, Osteoblasts physiology, Osteoporosis etiology, Oxidative Stress physiology, Risk Factors, Bone Diseases etiology, Diabetes Complications, Dyslipidemias complications, Fractures, Spontaneous etiology
- Abstract
The number of patients with lifestyle-related diseases is rapidly increasing in Japan. Metabolic syndrome caused by abdominal fat accumulation induces diabetes mellitus, dyslipidemia, and hypertension, resulting in an increase in cardiovascular diseases. On the other hand, recent studies have shown that the lifestyle-related diseases are risk factors of osteoporotic fractures. Although it remains still unclear how metabolic disorders affect bone tissue, oxidative stress and/or glycation stress might directly have negative impacts on bone tissue and increase the risk of fractures. In this review, we describe the association of diabetes mellitus and dyslipidemia with the fracture risk through oxidative stress and glycation stress.
- Published
- 2013
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