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Purpose: To report the relation between CT findings and the grade of malignancy in gastrointestinal stromal tumor (GIST), especially the uncommitted type of GIST., Materials and Methods: A total of 14 patients with histologically proven GIST (uncommitted type) underwent CT. Tumors were divided into three grades. HISTOLOGICALLY: Benign (mitotic index [MI] < 2/10 high-power fields [HPF]), borderline (2/10 HPF < or = MI < or = 5/10 HPF), and malignant (5/10 HPF < MI). We evaluated tumor size, cystic component, margin, and early enhancement., Results: All benign tumors were smaller than 5 cm, and most malignant tumors reached 5 cm. The size of borderline tumors was between the sizes of benign and malignant tumors. No benign tumors had cystic components, whereas all borderline and malignant tumors except for one case had cystic components. Only two huge malignant tumors had unclear margins. The relation between early enhancement and the grade of malignancy showed no tendency, but all duodenal tumors showed marked early enhancement irrespective of grade., Conclusion: The grade of malignancy of GIST (uncommitted type) and size, presence of cystic components, and margin were highly correlated. That is, 1) tumors smaller than 5 cm with no cystic components can be diagnosed as benign, whereas 2) tumors that have cystic components are borderline or malignant. 3) Tumors that have cystic components and unclear margin can be diagnosed as actively malignant.

A case of cyst of the tunica albuginea associated with intraabdominal testes is reported. A 35-year-old man was referred for further examination of azoospermia. Bilateral testes were nonpalpable in the scrotum and inguinal region. Ultrasonography and MR imaging demonstrated a 9 x 8 cm cystic lesion in the median suprapubic area. An open operation showed the cystic lesion to extend to the right spermatic cord and vas deferens. Left intraabdominal testis was also identified. Right orchiectomy and left orchiopexy were performed. Histopathological diagnosis was a cyst of the tunica albuginea. Atrophic seminiferous tubules were recognized at the junction of the cyst and the spermatic cord.

Glomerular clearing system was histologically studied to see what role it played in the flourishing, resolving and healing stages of Arthus-type nephritis in rabbits with intravenously injected colloidal carbon or ligation of thoracic duct. In the glomerulus, poorly soluble immune complexes were found within mesangial channels, a route for the egress of macromolecules from the peripheral mesangium through the hilus into the juxtaglomerular apparatus, other than phagocytosed by polymorphonuclear leukocytes. However, in the flourishing stage the immune deposits supplied to the external mesangial matrix seemed to originate in that made in the periglomerular blood capillary. Severer glomerulitis was observed under the condition of lymph stasis and juxta-glomerulitis, which was composed of inactive monocytes and plasmocytes, appeared late from the resolving stage. Coincidentally, stagnant amorphous, electron dense material was seen around the border between the external and internal mesangium or the wall of the efferent arteriole at the reflection site of Bowman's capsule. These features of juxta-glomerulitis may be explained by stagnant deposits transported upstream through mesangial channels. Carbon particles within mesangial channels were finally taken up by mesangial cells, whose endocytotic phagosome settled down until three weeks of the healing stage. Mesangial blebs or pseudopods protruding in the capillary lumen were observed in the resolving stage, the injection of colloidal carbon and the ligation of thoracic duct. The endothelium was lifted by mesangial blebs from the juxta-mesangial portion and seemed to interrupt the capillary blood stream. Mesangial influx was increased because of partly desquamation of the endothelium and macromolecules tended to accumulate in the sub-basement membrane of the para-mesangium. It's suggested that focal segmental sclerotic and adhesive lesions in the healing stage are correlated with the degree of juxta-glomerulitis and the peripheral mesangial blebs.