1. [The effectiveness of intravitreal administration of bevacizumab for choroidal neovascularization in retinal angioid streaks].
- Author
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Noda E, Joko T, Tasaka Y, and Ohashi Y
- Subjects
- Adult, Aged, Antibodies, Monoclonal, Humanized, Bevacizumab, Female, Humans, Male, Middle Aged, Visual Acuity, Vitreous Body, Angiogenesis Inhibitors administration & dosage, Angioid Streaks complications, Antibodies, Monoclonal administration & dosage, Choroidal Neovascularization drug therapy
- Abstract
Purpose: To investigate the effectiveness of intravitreal administration of bevacizumab (IVB) for choroidal neovascularization (CNV) in retinal angioid streaks (AS)., Subjects and Methods: Five eyes of four subjects with CNV in AS were observed for an average followup period of 12 months. The average greatest linear diameter (GLD) of the AS was 4315 microm before treatment. IVB (1.0 mg or 1.25 mg) was performed a total of two times at eight week intervals, and additional bevacizumab was administered whenever exudative changes occurred., Results: Visual acuity improved in one eye (20%), was maintained in two eyes (40%), and worsened in two eyes (40%). Recurrence of CNV was observed in two eyes (40%). Before treatment, the GLD was 2439, 2844, and 3654 microm in the three eyes in which visual acuity was maintained, and 5803 and 6837 microm in the two eyes with worsened visual acuity. Recurrence of CNV was observed in the two eyes with worsened visual acuity., Conclusion: Short-term CNV fibrosis and maintenance of visual acuity were achieved with IVB in cases in which the GLD was less than 3500 microm.
- Published
- 2010